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01-04-2020 | Addiction | Original Article

In vivo reduction of striatal D1R by RNA interference alters expression of D1R signaling-related proteins and enhances methamphetamine addiction in male rats

Authors: Alison D. Kreisler, Michael J. Terranova, Sucharita S. Somkuwar, Dvijen C. Purohit, Shanshan Wang, Brian P. Head, Chitra D. Mandyam

Published in: Brain Structure and Function | Issue 3/2020

Abstract

This study sought to determine if reducing dopamine D1 receptor (D1R) expression in the dorsal striatum (DS) via RNA-interference alters methamphetamine self-administration. A lentiviral construct containing a short hairpin RNA (shRNA) was used to knock down D1R expression (D1RshRNA). D1RshRNA in male rats increased responding for methamphetamine (i.v.) under a fixed-ratio schedule in an extended access paradigm, compared to D1R-intact rats. D1RshRNA also produced a vertical shift in a dose–response paradigm and enhanced responding for methamphetamine in a progressive-ratio schedule, generating a drug-vulnerable phenotype. D1RshRNA did not alter responding for sucrose (oral) under a fixed-ratio schedule compared to D1R-intact rats. Western blotting confirmed reduced D1R expression in methamphetamine and sucrose D1RshRNA rats. D1RshRNA reduced the expression of PSD-95 and MAPK-1 and increased the expression of dopamine transporter (DAT) in the DS from methamphetamine, but not sucrose rats. Sucrose density gradient fractionation was performed in behavior-naïve controls, D1RshRNA- and D1R-intact rats to determine the subcellular localization of D1Rs, DAT and D1R signaling proteins. D1Rs, DAT, MAPK-1 and PSD-95 predominantly localized to heavy fractions, and the membrane/lipid raft protein caveolin-1 (Cav-1) and flotillin-1 were distributed equally between buoyant and heavy fractions in controls. Methamphetamine increased localization of PSD-95, Cav-1, and flotillin-1 in D1RshRNA and D1R-intact rats to buoyant fractions. Our studies indicate that reduced D1R expression in the DS increases vulnerability to methamphetamine addiction-like behavior, and this is accompanied by striatal alterations in the expression of DAT and D1R signaling proteins and is independent of the subcellular localization of these proteins.

Abrahams BS, Rutherford JD, Mallet PE, Beninger RJ (1998) Place conditioning with the dopamine D1-like receptor agonist SKF 82958 but not SKF 81297 or SKF 77434. Eur J Pharmacol 343:111–118PubMed

Ahmed SH, Koob GF (2004) Changes in response to a dopamine receptor antagonist in rats with escalating cocaine intake. Psychopharmacology 172:450–454PubMed

Allen JA, Halverson-Tamboli RA, Rasenick MM (2007) Lipid raft microdomains and neurotransmitter signalling. Nat Rev Neurosci 8:128–140PubMed

Bahi A, Dreyer JL (2012) Involvement of nucleus accumbens dopamine D1 receptors in ethanol drinking, ethanol-induced conditioned place preference, and ethanol-induced psychomotor sensitization in mice. Psychopharmacology 222:141–153PubMed

Bai J, Blot K, Tzavara E, Nosten-Bertrand M, Giros B, Otani S (2014) Inhibition of dopamine transporter activity impairs synaptic depression in rat prefrontal cortex through over-stimulation of D1 receptors. Cereb Cortex 24:945–955PubMed

Bardo MT, Valone JM, Bevins RA (1999) Locomotion and conditioned place preference produced by acute intravenous amphetamine: role of dopamine receptors and individual differences in amphetamine self-administration. Psychopharmacology 143:39–46PubMed

Baucum AJ, Rau KS, Riddle EL, Hanson GR, Fleckenstein AE (2004) Methamphetamine increases dopamine transporter higher molecular weight complex formation via a dopamine- and hyperthermia-associated mechanism. J Neurosci 24:3436–3443PubMedPubMedCentral

Becker JB (2016) Sex differences in addiction. Dialogues Clin Neurosci 18:395–402PubMedPubMedCentral

Becker JB, Chartoff E (2019) Sex differences in neural mechanisms mediating reward and addiction. Neuropsychopharmacology 44:166–183PubMed

Becker JB, McClellan ML, Reed BG (2017) Sex differences, gender and addiction. J Neurosci Res 95:136–147PubMedPubMedCentral

Bello NT, Lucas LR, Hajnal A (2002) Repeated sucrose access influences dopamine D2 receptor density in the striatum. NeuroReport 13:1575–1578PubMedPubMedCentral

Berglind WJ, Case JM, Parker MP, Fuchs RA, See RE (2006) Dopamine D1 or D2 receptor antagonism within the basolateral amygdala differentially alters the acquisition of cocaine-cue associations necessary for cue-induced reinstatement of cocaine-seeking. Neuroscience 137:699–706PubMed

Brennan KA, Carati C, Lea RA, Fitzmaurice PS, Schenk S (2009) Effect of D1-like and D2-like receptor antagonists on methamphetamine and 3,4-methylenedioxymethamphetamine self-administration in rats. Behav Pharmacol 20:688–694PubMed

Cagniard B, Sotnikova TD, Gainetdinov RR, Zhuang X (2014) The dopamine transporter expression level differentially affects responses to cocaine and amphetamine. J Neurogenet 28:112–121PubMed

Caine SB, Thomsen M, Gabriel KI, Berkowitz JS, Gold LH, Koob GF, Tonegawa S, Zhang J, Xu M (2007) Lack of self-administration of cocaine in dopamine D1 receptor knock-out mice. J Neurosci 27:13140–13150PubMedPubMedCentral

Carati C, Schenk S (2011) Role of dopamine D1- and D2-like receptor mechanisms in drug-seeking following methamphetamine self-administration in rats. Pharmacol Biochem Behav 98:449–454PubMed

Chakrabarti S, Chang A, Liu NJ, Gintzler AR (2016) Chronic opioid treatment augments caveolin-1 scaffolding: relevance to stimulatory mu-opioid receptor adenylyl cyclase signaling. J Neurochem 139:737–747PubMedPubMedCentral

Chaudhri N, Sahuque LL, Janak PH (2009) Ethanol seeking triggered by environmental context is attenuated by blocking dopamine D1 receptors in the nucleus accumbens core and shell in rats. Psychopharmacology 207:303–314PubMedPubMedCentral

Chen J, Rusnak M, Lombroso PJ, Sidhu A (2009) Dopamine promotes striatal neuronal apoptotic death via ERK signaling cascades. Eur J Neurosci 29:287–306PubMedPubMedCentral

Cohen AW, Park DS, Woodman SE, Williams TM, Chandra M, Shirani J, Pereira de Souza A, Kitsis RN, Russell RG, Weiss LM, Tang B, Jelicks LA, Factor SM, Shtutin V, Tanowitz HB, Lisanti MP (2003) Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts. Am J Physiol Cell Physiol 284:C457–474PubMed

Cremona ML, Matthies HJ, Pau K, Bowton E, Speed N, Lute BJ, Anderson M, Sen N, Robertson SD, Vaughan RA, Rothman JE, Galli A, Javitch JA, Yamamoto A (2011) Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT. Nat Neurosci 14:469–477PubMedPubMedCentral

Cui W, Ren Y, Wang S, Zeng M, Han S, Li J, Han R (2018) The role of caveolin-1 in morphine-induced structural plasticity in primary cultured mouse cerebral cortical neurons. Neurosci Lett 665:38–42PubMed

Dumartin B, Jaber M, Gonon F, Caron MG, Giros B, Bloch B (2000) Dopamine tone regulates D1 receptor trafficking and delivery in striatal neurons in dopamine transporter-deficient mice. Proc Natl Acad Sci USA 97:1879–1884PubMed

Engelman JA, Chu C, Lin A, Jo H, Ikezu T, Okamoto T, Kohtz DS, Lisanti MP (1998) Caveolin-mediated regulation of signaling along the p42/44 MAP kinase cascade in vivo. A role for the caveolin-scaffolding domain. FEBS Lett 428:205–211PubMed

Engelman JA, Zhang XL, Razani B, Pestell RG, Lisanti MP (1999) p42/44 MAP kinase-dependent and -independent signaling pathways regulate caveolin-1 gene expression. Activation of Ras-MAP kinase and protein kinase a signaling cascades transcriptionally down-regulates caveolin-1 promoter activity. J Biol Chem 274:32333–32341PubMed

Evans WET, Coyer RL, Sandusky MF, Van Fleet MJ, Moore JG, Nyquist SE (2003) Characterization of membrane rafts isolated from rat sertoli cell cultures: caveolin and flotillin-1 content. J Androl 24:812–821PubMed

Fasano C, Bourque MJ, Lapointe G, Leo D, Thibault D, Haber M, Kortleven C, Desgroseillers L, Murai KK, Trudeau LE (2013) Dopamine facilitates dendritic spine formation by cultured striatal medium spiny neurons through both D1 and D2 dopamine receptors. Neuropharmacology 67:432–443PubMed

Fenu S, Spina L, Rivas E, Longoni R, Di Chiara G (2006) Morphine-conditioned single-trial place preference: role of nucleus accumbens shell dopamine receptors in acquisition, but not expression. Psychopharmacology 187:143–153PubMed

Galbiati F, Volonte D, Engelman JA, Watanabe G, Burk R, Pestell RG, Lisanti MP (1998) Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade. Embo J 17:6633–6648PubMedPubMedCentral

Galinato MH, Orio L, Mandyam CD (2015) Methamphetamine differentially affects BDNF and cell death factors in anatomically defined regions of the hippocampus. Neuroscience 286:97–108PubMed

Galinato MH, Lockner JW, Fannon-Pavlich MJ, Sobieraj JC, Staples MC, Somkuwar SS, Ghofranian A, Chaing S, Navarro AI, Joea A, Luikart BW, Janda KD, Heyser C, Koob GF, Mandyam CD (2018a) A synthetic small-molecule Isoxazole-9 protects against methamphetamine relapse. Mol Psychiatry 23:629–638PubMed

Galinato MH, Takashima Y, Fannon MJ, Quach LW, Morales Silva RJ, Mysore KK, Terranova MJ, Dutta RR, Ostrom RW, Somkuwar SS, Mandyam CD (2018b) Neurogenesis during abstinence is necessary for context-driven methamphetamine-related memory. J Neurosci 38:2029–2042PubMedPubMedCentral

Gao X, Wu D, Dou L, Zhang H, Huang L, Zeng J, Zhang Y, Yang C, Li H, Liu L, Ma B, Yuan Q (2019) Protective effects of mesenchymal stem cells overexpressing extracellular regulating kinase 1/2 against stroke in rats. Brain Res Bull 149:42–52PubMed

Gerfen CR, Young WS 3rd (1988) Distribution of striatonigral and striatopallidal peptidergic neurons in both patch and matrix compartments: an in situ hybridization histochemistry and fluorescent retrograde tracing study. Brain Res 460:161–167PubMed

Ghisi V, Ramsey AJ, Masri B, Gainetdinov RR, Caron MG, Salahpour A (2009) Reduced D2-mediated signaling activity and trans-synaptic upregulation of D1 and D2 dopamine receptors in mice overexpressing the dopamine transporter. Cell Signal 21:87–94PubMed

Giros B, Jaber M, Jones SR, Wightman RM, Caron MG (1996) Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature 379:606–612PubMed

Gong X, Yue K, Ma B, Xing J, Gan Y, Wang D, Jin G, Li C (2016) Levo-tetrahydropalmatine, a natural, mixed dopamine receptor antagonist, inhibits methamphetamine self-administration and methamphetamine-induced reinstatement. Pharmacol Biochem Behav 144:67–72PubMed

Gross NB, Duncker PC, Marshall JF (2011) Striatal dopamine D1 and D2 receptors: widespread influences on methamphetamine-induced dopamine and serotonin neurotoxicity. Synapse 65:1144–1155PubMed

Haberny SL, Berman Y, Meller E, Carr KD (2004) Chronic food restriction increases D-1 dopamine receptor agonist-induced phosphorylation of extracellular signal-regulated kinase 1/2 and cyclic AMP response element-binding protein in caudate-putamen and nucleus accumbens. Neuroscience 125:289–298PubMed

He Y, Yu LP, Jin GZ (2009) Differential distributions and trafficking properties of dopamine D1 and D5 receptors in nerve cells. Neurosci Bull 25:43–53PubMedPubMedCentral

Head BP, Hu Y, Finley JC, Saldana MD, Bonds JA, Miyanohara A, Niesman IR, Ali SS, Murray F, Insel PA, Roth DM, Patel HH, Patel PM (2011) Neuron-targeted caveolin-1 protein enhances signaling and promotes arborization of primary neurons. J Biol Chem 286:33310–33321PubMedPubMedCentral

Ince E, Ciliax BJ, Levey AI (1997) Differential expression of D1 and D2 dopamine and m4 muscarinic acetylcholine receptor proteins in identified striatonigral neurons. Synapse 27:357–366PubMed

Jaramillo AA, Randall PA, Stewart S, Fortino B, Van Voorhies K, Besheer J (2018) Functional role for cortical-striatal circuitry in modulating alcohol self-administration. Neuropharmacology 130:42–53PubMed

Jiao H, Zhang L, Gao F, Lou D, Zhang J, Xu M (2007) Dopamine D(1) and D(3) receptors oppositely regulate NMDA- and cocaine-induced MAPK signaling via NMDA receptor phosphorylation. J Neurochem 103:840–848PubMed

Johnson PM, Kenny PJ (2010) Dopamine D2 receptors in addiction-like reward dysfunction and compulsive eating in obese rats. Nat Neurosci 13:635–641PubMedPubMedCentral

Jones SR, Gainetdinov RR, Jaber M, Giros B, Wightman RM, Caron MG (1998) Profound neuronal plasticity in response to inactivation of the dopamine transporter. Proc Natl Acad Sci USA 95:4029–4034PubMed

Kang MJ, Chung YH, Hwang CI, Murata M, Fujimoto T, Mook-Jung IH, Cha CI, Park WY (2006) Caveolin-1 upregulation in senescent neurons alters amyloid precursor protein processing. Exp Mol Med 38:126–133PubMed

Kim A, Mandyam CD (2014) Methamphetamine affects cell proliferation in the medial prefrontal cortex: a new niche for toxicity. Pharmacol Biochem Behav 126:90–96PubMedPubMedCentral

Kong MM, Hasbi A, Mattocks M, Fan T, O'Dowd BF, George SR (2007) Regulation of D1 dopamine receptor trafficking and signaling by caveolin-1. Mol Pharmacol 72:1157–1170PubMed

Kreisler AD, Garcia MG, Spierling SR, Hui BE, Zorrilla EP (2017) Extended vs. brief intermittent access to palatable food differently promote binge-like intake, rejection of less preferred food, and weight cycling in female rats. Physiol Behav 177:305–316PubMed

Kreisler AD, Mattock M, Zorrilla EP (2018) The duration of intermittent access to preferred sucrose-rich food affects binge-like intake, fat accumulation, and fasting glucose in male rats. Appetite 130:59–69PubMedPubMedCentral

Kruyer A, Scofield MD, Wood D, Reissner KJ, Kalivas PW (2019) Heroin cue-evoked astrocytic structural plasticity at nucleus accumbens synapses inhibits heroin seeking. Biol Psychiatry 86:811–819PubMed

Lindgren N, Goiny M, Herrera-Marschitz M, Haycock JW, Hokfelt T, Fisone G (2002) Activation of extracellular signal-regulated kinases 1 and 2 by depolarization stimulates tyrosine hydroxylase phosphorylation and dopamine synthesis in rat brain. Eur J Neurosci 15:769–773PubMed

Liu Y, Young KA, Curtis JT, Aragona BJ, Wang Z (2011) Social bonding decreases the rewarding properties of amphetamine through a dopamine D1 receptor-mediated mechanism. J Neurosci 31:7960–7966PubMedPubMedCentral

Lobo MK, Nestler EJ (2011) The striatal balancing act in drug addiction: distinct roles of direct and indirect pathway medium spiny neurons. Front Neuroanat 5:41PubMedPubMedCentral

Lobo MK, Covington HE 3rd, Chaudhury D, Friedman AK, Sun H, Damez-Werno D, Dietz DM, Zaman S, Koo JW, Kennedy PJ, Mouzon E, Mogri M, Neve RL, Deisseroth K, Han MH, Nestler EJ (2010) Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science 330:385–390PubMedPubMedCentral

Lynch WJ (2006) Sex differences in vulnerability to drug self-administration. Exp Clin Psychopharmacol 14:34–41PubMed

Mandyam CD, Norris RD, Eisch AJ (2004) Chronic morphine induces premature mitosis of proliferating cells in the adult mouse subgranular zone. J Neurosci Res 76:783–794PubMed

Mandyam CD, Wee S, Eisch AJ, Richardson HN, Koob GF (2007) Methamphetamine self-administration and voluntary exercise have opposing effects on medial prefrontal cortex gliogenesis. J Neurosci 27:11442–11450PubMedPubMedCentral

Mandyam CD, Schilling JM, Cui W, Egawa J, Niesman IR, Kellerhals SE, Staples MC, Busija AR, Risbrough VB, Posadas E, Grogman GC, Chang JW, Roth DM, Patel PM, Patel HH, Head BP (2015) Neuron-targeted caveolin-1 improves molecular signaling, plasticity, and behavior dependent on the hippocampus in adult and aged mice. Biol Psychiatry 81:101–110PubMedPubMedCentral

Mastrangelo L, Kim JE, Miyanohara A, Kang TH, Friedmann T (2012) Purinergic signaling in human pluripotent stem cells is regulated by the housekeeping gene encoding hypoxanthine guanine phosphoribosyltransferase. Proc Natl Acad Sci USA 109:3377–3382PubMed

Mizoguchi H, Yamada K, Mizuno M, Mizuno T, Nitta A, Noda Y, Nabeshima T (2004) Regulations of methamphetamine reward by extracellular signal-regulated kinase 1/2/ets-like gene-1 signaling pathway via the activation of dopamine receptors. Mol Pharmacol 65:1293–1301PubMed

Morgan D, Brebner K, Lynch WJ, Roberts DC (2002) Increases in the reinforcing efficacy of cocaine after particular histories of reinforcement. Behav Pharmacol 13:389–396PubMed

Nestler EJ (2001) Molecular basis of long-term plasticity underlying addiction. Nat Rev Neurosci 2:119–128PubMed

Nguyen JD, Aarde SM, Cole M, Vandewater SA, Grant Y, Taffe MA (2016) Locomotor stimulant and rewarding effects of inhaling methamphetamine, MDPV, and mephedrone via electronic cigarette-type technology. Neuropsychopharmacology 41:2759–2771PubMedPubMedCentral

Noonan MA, Bulin SE, Fuller DC, Eisch AJ (2010) Reduction of adult hippocampal neurogenesis confers vulnerability in an animal model of cocaine addiction. J Neurosci 30:304–315PubMedPubMedCentral

Noori-Daloii MR, Mojarrad M, Rashidi-Nezhad A, Kheirollahi M, Shahbazi A, Khaksari M, Korzebor A, Goodarzi A, Ebrahimi M, Noori-Daloii AR (2012) Use of siRNA in knocking down of dopamine receptors, a possible therapeutic option in neuropsychiatric disorders. Mol Biol Rep 39:2003–2010PubMed

Oliver RJ, Purohit DC, Kharidia KM, Mandyam CD (2019) Transient chemogenetic inhibition of D1-MSNs in the dorsal striatum enhances methamphetamine self-administration. Brain Sci 9:e330PubMed

Piazza PV, Deminiere JM, Le Moal M, Simon H (1989) Factors that predict individual vulnerability to amphetamine self-administration. Science 245:1511–1513PubMed

Piazza PV, Deroche-Gamonent V, Rouge-Pont F, Le Moal M (2000) Vertical shifts in self-administration dose–response functions predict a drug-vulnerable phenotype predisposed to addiction. J Neurosci 20:4226–4232PubMedPubMedCentral

Porras G, Berthet A, Dehay B, Li Q, Ladepeche L, Normand E, Dovero S, Martinez A, Doudnikoff E, Martin-Negrier ML, Chuan Q, Bloch B, Choquet D, Boue-Grabot E, Groc L, Bezard E (2012) PSD-95 expression controls L-DOPA dyskinesia through dopamine D1 receptor trafficking. J Clin Invest 122:3977–3989PubMedPubMedCentral

Rajendran L, Le Lay S, Illges H (2007) Raft association and lipid droplet targeting of flotillins are independent of caveolin. Biol Chem 388:307–314PubMed

Richardson NR, Roberts DC (1996) Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy. J Neurosci Methods 66:1–11PubMed

Roberts DC (1993) Self-administration of GBR 12909 on a fixed ratio and progressive ratio schedule in rats. Psychopharmacology 111:202–206PubMed

Roberts DC, Loh EA, Vickers G (1989) Self-administration of cocaine on a progressive ratio schedule in rats: dose–response relationship and effect of haloperidol pretreatment. Psychopharmacology 97:535–538PubMed

Robison LS, Ananth M, Hadjiargyrou M, Komatsu DE, Thanos PK (2017) Chronic oral methylphenidate treatment reversibly increases striatal dopamine transporter and dopamine type 1 receptor binding in rats. J Neural Trans (Vienna, Austria: 1996) 124:655–667

Rospond B, Sadakierska-Chudy A, Kazek G, Krosniak M, Bystrowska B, Filip M (2019) Assessment of metabolic and hormonal profiles and striatal dopamine D2 receptor expression following continuous or scheduled high-fat or high-sucrose diet in rats. Pharmacol Rep 71:1–12PubMed

Rui G, Guangjian Z, Yong W, Jie F, Yanchao C, Xi J, Fen L (2013) High frequency electro-acupuncture enhances striatum DAT and D1 receptor expression, but decreases D2 receptor level in 6-OHDA lesioned rats. Behav Brain Res 237:263–269PubMed

Rupniak NM, Briggs RS, Petersen MM, Mann S, Reavill C, Jenner P, Marsden CD (1986) Differential alterations in striatal acetylcholine function in rats during 12 months' continuous administration of haloperidol, sulpiride, or clozapine. Clin Neuropharmacol 9:282–292PubMed

Salahpour A, Ramsey AJ, Medvedev IO, Kile B, Sotnikova TD, Holmstrand E, Ghisi V, Nicholls PJ, Wong L, Murphy K, Sesack SR, Wightman RM, Gainetdinov RR, Caron MG (2008) Increased amphetamine-induced hyperactivity and reward in mice overexpressing the dopamine transporter. Proc Natl Acad Sci USA 105:4405–4410PubMed

Sase A, Aher YD, Saroja SR, Ganesan MK, Sase S, Holy M, Hoger H, Bakulev V, Ecker GF, Langer T, Sitte HH, Leban J, Lubec G (2016) A heterocyclic compound CE-103 inhibits dopamine reuptake and modulates dopamine transporter and dopamine D1–D3 containing receptor complexes. Neuropharmacology 102:186–196PubMed

Schwendt M, Rocha A, See RE, Pacchioni AM, McGinty JF, Kalivas PW (2009) Extended methamphetamine self-administration in rats results in a selective reduction of dopamine transporter levels in the prefrontal cortex and dorsal striatum not accompanied by marked monoaminergic depletion. J Pharmacol Exp Ther 331:555–562PubMedPubMedCentral

Segal DS, Kuczenski R, O'Neil ML, Melega WP, Cho AK (2005) Prolonged exposure of rats to intravenous methamphetamine: behavioral and neurochemical characterization. Psychopharmacology 180:501–512PubMed

Shen J, Li Y, Qu C, Xu L, Sun H, Zhang J (2019) The enriched environment ameliorates chronic unpredictable mild stress-induced depressive-like behaviors and cognitive impairment by activating the SIRT1/miR-134 signaling pathway in hippocampus. J Affect Disord 248:81–90PubMed

Shi X, McGinty JF (2011) D1 and D2 dopamine receptors differentially mediate the activation of phosphoproteins in the striatum of amphetamine-sensitized rats. Psychopharmacology 214:653–663PubMed

Shippenberg TS, Bals-Kubik R, Herz A (1993) Examination of the neurochemical substrates mediating the motivational effects of opioids: role of the mesolimbic dopamine system and D-1 vs. D-2 dopamine receptors. J Pharmacol Exp Ther 265:53–59PubMed

Somkuwar SS, Fannon MJ, Head BP, Mandyam CD (2016) Methamphetamine reduces expression of caveolin-1 in the dorsal striatum: implication for dysregulation of neuronal function. Neuroscience 328:147–156PubMedPubMedCentral

Song Z, Kalyani M, Becker JB (2018) Sex differences in motivated behaviors in animal models. Curr Opin Behav Sci 23:98–102PubMedPubMedCentral

Spielewoy C, Biala G, Roubert C, Hamon M, Betancur C, Giros B (2001) Hypolocomotor effects of acute and daily d-amphetamine in mice lacking the dopamine transporter. Psychopharmacology 159:2–9PubMedPubMedCentral

Spina L, Fenu S, Longoni R, Rivas E, Di Chiara G (2006) Nicotine-conditioned single-trial place preference: selective role of nucleus accumbens shell dopamine D1 receptors in acquisition. Psychopharmacology 184:447–455PubMed

Stary CM, Tsutsumi YM, Patel PM, Head BP, Patel HH, Roth DM (2012) Caveolins: targeting pro-survival signaling in the heart and brain. Front Physiol 3:393PubMedPubMedCentral

Sun W, Ginovart N, Ko F, Seeman P, Kapur S (2003) In vivo evidence for dopamine-mediated internalization of D2-receptors after amphetamine: differential findings with [3H]raclopride versus [3H]spiperone. Mol Pharmacol 63:456–462PubMed

Sun J, Xu J, Cairns NJ, Perlmutter JS, Mach RH (2012) Dopamine D1, D2, D3 receptors, vesicular monoamine transporter type-2 (VMAT2) and dopamine transporter (DAT) densities in aged human brain. PLoS ONE 7:e49483PubMedPubMedCentral

Tonissaar M, Herm L, Rinken A, Harro J (2006) Individual differences in sucrose intake and preference in the rat: circadian variation and association with dopamine D2 receptor function in striatum and nucleus accumbens. Neurosci Lett 403:119–124PubMed

Turner C, De Luca M, Wolfheimer J, Hernandez N, Madsen KL, Schmidt HD (2020) Administration of a novel high affinity PICK1 PDZ domain inhibitor attenuates cocaine seeking in rats. Neuropharmacology 164:107901PubMed

Vazquez D, Pribut HJ, Burton AC, Tennyson SS, Roesch MR (2019) Prior cocaine self-administration impairs attention signals in anterior cingulate cortex. Neuropsychopharmacology 45:833–841PubMedPubMedCentral

Voulalas PJ, Schetz J, Undieh AS (2011) Differential subcellular distribution of rat brain dopamine receptors and subtype-specific redistribution induced by cocaine. Mol Cell Neurosci 46:645–654PubMedPubMedCentral

Wise RA (2006) Role of brain dopamine in food reward and reinforcement. Philos Trans R Soc Lond B Biol Sci 361:1149–1158PubMedPubMedCentral

Worsley JN, Moszczynska A, Falardeau P, Kalasinsky KS, Schmunk G, Guttman M, Furukawa Y, Ang L, Adams V, Reiber G, Anthony RA, Wickham D, Kish SJ (2000) Dopamine D1 receptor protein is elevated in nucleus accumbens of human, chronic methamphetamine users. Mol Psychiatry 5:664–672PubMed

Xi ZX, Kleitz HK, Deng X, Ladenheim B, Peng XQ, Li X, Gardner EL, Stein EA, Cadet JL (2009) A single high dose of methamphetamine increases cocaine self-administration by depletion of striatal dopamine in rats. Neuroscience 161:392–402PubMedPubMedCentral

Yao WD, Gainetdinov RR, Arbuckle MI, Sotnikova TD, Cyr M, Beaulieu JM, Torres GE, Grant SG, Caron MG (2004) Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticity. Neuron 41:625–638PubMed

Yin WL, Yin WG, Huang BS, Wu LX (2017) Neuroprotective effects of lentivirus-mediated cystathionine-beta-synthase overexpression against 6-OHDA-induced Parkinson's disease rats. Neurosci Lett 657:45–52PubMed

Young EA, Dreumont SE, Cunningham CL (2014) Role of nucleus accumbens dopamine receptor subtypes in the learning and expression of alcohol-seeking behavior. Neurobiol Learn Mem 108:28–37PubMed

Yu P, Villar VA, Jose PA (2013) Methods for the study of dopamine receptors within lipid rafts of kidney cells. Methods Mol Biol 964:15–24PubMedPubMedCentral

Zhang J, Saur T, Duke AN, Grant SG, Platt DM, Rowlett JK, Isacson O, Yao WD (2014) Motor impairments, striatal degeneration, and altered dopamine-glutamate interplay in mice lacking PSD-95. J Neurogenet 28:98–111PubMedPubMedCentral

Title: In vivo reduction of striatal D1R by RNA interference alters expression of D1R signaling-related proteins and enhances methamphetamine addiction in male rats
Authors: Alison D. Kreisler
Michael J. Terranova
Sucharita S. Somkuwar
Dvijen C. Purohit
Shanshan Wang
Brian P. Head
Chitra D. Mandyam
Publication date: 01-04-2020
Publisher: Springer Berlin Heidelberg
Keywords: Addiction
Addiction
Published in: Brain Structure and Function / Issue 3/2020
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-020-02059-w

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In vivo reduction of striatal D1R by RNA interference alters expression of D1R signaling-related proteins and enhances methamphetamine addiction in male rats

Abstract

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Abstract

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