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Published in:

01-07-2012 | Review

Acute tubulointerstitial nephritis

Authors: Tim Ulinski, Anne-Laure Sellier-Leclerc, Elena Tudorache, Albert Bensman, Bilal Aoun

Published in: Pediatric Nephrology | Issue 7/2012

Abstract

Acute tubulointerstitial nephritis (TIN) is a frequent cause of acute renal failure, characterised by the presence of inflammatory cell infiltrate in the interstitium of the kidney. Immuno-allergic reaction to certain medications, mainly non-steroidal anti-inflammatory drugs and antibiotics are by far the most important etiology for TIN today, but other situations such as infections, toxins, and vasculitis are known to induce TIN. Incidence of TIN is increasing, probably due to prescription habits and NSAID overuse, representing 3–7% of acute kidney injury in biopsies in children. Avoidance of the causal substance and rapid steroid therapy are hallmarks for patient care, but spontaneous initial recovery is very frequent and the general prognosis seems satisfactory. However, development of chronic TIN, without response to steroid or other immunosuppressive treatment, is possible. As the largest part of TIN is secondary to certain drugs, clear indications in particular for NSAID or antibiotics should be respected to reduce the number of TIN cases.

Perazella MA, Markowitz GS (2010) Drug-induced acute interstitial nephritis. Nat Rev Nephrol 6:461–470PubMedCrossRef

Lanewala A, Mubarak M, Akhter F, Aziz S, Bhatti S, Kazi JI (2009) Pattern of pediatric renal disease observed in native renal biopsies in Pakistan. J Nephrol 22:739–746PubMed

Greising J, Trachtman H, Gauthier B, Valderrama E (1990) Acute interstitial nephritis in adolescents and young adults. Child Nephrol Urol 10:189–195PubMed

Praga M, Gonzalez E (2010) Acute interstitial nephritis. Kidney Int 77:956–961PubMedCrossRef

Heller F, Lindenmeyer MT, Cohen CD, Brandt U, Draganovici D, Fischereder M, Kretzler M, Anders HJ, Sitter T, Mosberger I, Kerjaschki D, Regele H, Schlondorff D, Segerer S (2007) The contribution of B cells to renal interstitial inflammation. Am J Pathol 170:457–468PubMedCrossRef

Grandaliano G, Gesualdo L, Ranieri E, Monno R, Montinaro V, Marra F, Schena FP (1996) Monocyte chemotactic peptide-1 expression in acute and chronic human nephritides: a pathogenetic role in interstitial monocytes recruitment. J Am Soc Nephrol 7:906–913PubMed

Kobayashi Y, Honda M, Yoshikawa N, Ito H (2000) Acute tubulointerstitial nephritis in 21 Japanese children. Clin Nephrol 54:191–197PubMed

Schurman SJ, Alderman JM, Massanari M, Lacson AG, Perlman SA (1998) Tubulointerstitial nephritis induced by the leukotriene receptor antagonist pranlukast. Chest 114:1220–1223PubMedCrossRef

Ejaz P, Bhojani K, Joshi VR (2004) NSAIDs and kidney. J Assoc Physicians India 52:632–640PubMed

10.

Pirani CL, Valeri A, D’Agati V, Appel GB (1987) Renal toxicity of nonsteroidal anti-inflammatory drugs. Contrib Nephrol 55:159–175PubMed

11.

Bender WL, Whelton A, Beschorner WE, Darwish MO, Hall-Craggs M, Solez K (1984) Interstitial nephritis, proteinuria, and renal failure caused by nonsteroidal anti-inflammatory drugs. Immunologic characterization of the inflammatory infiltrate. Am J Med 76:1006–1012PubMedCrossRef

12.

Tanaka H, Waga S, Tateyama T, Sugimoto K, Kakizaki Y, Yokoyama M (1999) Acute tubulointerstitial nephritis following intravenous immunoglobulin therapy in a male infant with minimal-change nephrotic syndrome. Tohoku J Exp Med 189:155–161PubMedCrossRef

13.

McGregor AR, Moore ML, Bailey RR, Robson RA, Lynn KL (1990) Disseminated prostatic carcinoma presenting with acute interstitial nephritis and microangiopathic haemolytic anaemia. Aust NZ J Med 20:170–172CrossRef

14.

Yim HE, Yoo KH, Seo WH, Won NH, Hong YS, Lee JW (2007) Acute tubulointerstitial nephritis following ingestion of Chlorella tablets. Pediatr Nephrol 22:887–888PubMedCrossRef

15.

Cohen SD, Chawla LS, Kimmel PL (2008) Acute kidney injury in patients with human immunodeficiency virus infection. Curr Opin Crit Care 14:647–653PubMedCrossRef

16.

Yang CW (2007) Leptospirosis renal disease: understanding the initiation by Toll-like receptors. Kidney Int 72:918–925PubMedCrossRef

17.

Marcus SB, Brown JB, Melin-Aldana H, Strople JA (2008) Tubulointerstitial nephritis: an extraintestinal manifestation of Crohn disease in children. J Pediatr Gastroenterol Nutr 46:338–341PubMedCrossRef

18.

Yu F, Wu LH, Tan Y, Li LH, Wang CL, Wang WK, Qu Z, Chen MH, Gao JJ, Li ZY, Zheng X, Ao J, Zhu SN, Wang SX, Zhao MH, Zou WZ, Liu G (2010) Tubulointerstitial lesions of patients with lupus nephritis classified by the 2003 International Society of Nephrology and Renal Pathology Society system. Kidney Int 77:820–829PubMedCrossRef

19.

Yim HE, Yoo KH, Hong YS, Lee JW (2010) Acute tubulointerstitial nephritis complicated by Salmonella enteritidis gastroenteritis. Clin Nephrol 73:247–249PubMed

20.

Inaba H, Jones DP, Gaber LW, Shenep JL, Call SK, Pui CH, Razzouk BI (2007) BK virus-induced tubulointerstitial nephritis in a child with acute lymphoblastic leukemia. J Pediatr 151:215–217PubMedCrossRef

21.

Shin JI, Lee JS, Jeong HJ (2006) Azathioprine and tubulointerstitial nephritis in HSP. J Rheumatol 33:2551PubMed

22.

Oikonomou K, Kapsoritakis A, Eleftheriadis T, Stefanidis I, Potamianos S (2011) Renal manifestations and complications of inflammatory bowel disease. Inflamm Bowel Dis 17:1034–1045PubMedCrossRef

23.

Ekong EB, Jaar BG, Weaver VM (2006) Lead-related nephrotoxicity: a review of the epidemiologic evidence. Kidney Int 70:2074–2084PubMed

24.

Steel-Duncan J, Miller M, Pierre RB, Dunkley-Thompson J, Palmer P, Evans-Gilbert T, Rodriquez B, Christie CD (2008) Renal manifestations in HIV-infected Jamaican children. West Indian Med J 57:246–252PubMed

25.

Strauss J, Abitbol C, Zilleruelo G, Scott G, Paredes A, Malaga S, Montane B, Mitchell C, Parks W, Pardo V (1989) Renal disease in children with the acquired immunodeficiency syndrome. N Engl J Med 321:625–630PubMedCrossRef

26.

Lee JW, Kim HJ, Sung SH, Lee SJ (2005) A case of tubulointerstitial nephritis and uveitis syndrome with severe immunologic dysregulation. Pediatr Nephrol 20:1805–1808PubMedCrossRef

27.

Rossert J (2001) Drug-induced acute interstitial nephritis. Kidney Int 60:804–817PubMedCrossRef

28.

Sonoda K, Mukasa A, Matsuzaki G, Nomoto K (1995) The induction of renal autoantigen-specific T cells by a local Listeria monocytogenes infection. Immunology 86:190–198PubMed

29.

Hawkins EP, Berry PL, Silva FG (1989) Acute tubulointerstitial nephritis in children: clinical, morphologic, and lectin studies. A report of the Southwest Pediatric Nephrology Study Group. Am J Kidney Dis 14:466–471PubMed

30.

Joh K, Shibasaki T, Ohkawa K, Aizawa S (1989) Induction of interstitial nephritis in rats by basement membrane of human origin. Acta Pathol Jpn 39:551–557PubMed

31.

Takemura Y, Koshimichi M, Sugimoto K, Yanagida H, Fujita S, Miyazawa T, Miyazaki K, Okada M, Takemura T (2010) A tubulointerstitial nephritis antigen gene defect causes childhood-onset chronic renal failure. Pediatr Nephrol 25:1349–1353PubMedCrossRef

32.

Sanders PW (2011) Light chain-mediated tubulopathies. Contrib Nephrol 169:262–269PubMedCrossRef

33.

Batuman V (2007) Proximal tubular injury in myeloma. Contrib Nephrol 153:87–104PubMedCrossRef

34.

Christensen EI, Birn H (2001) Megalin and cubilin: synergistic endocytic receptors in renal proximal tubule. Am J Physiol Ren Physiol 280:F562–F573

35.

Tan Y, Yu F, Qu Z, Su T, Xing GQ, Wu LH, Wang FM, Liu G, Yang L, Zhao MH (2011) Modified C-reactive protein might be a target autoantigen of TINU syndrome. Clin J Am Soc Nephrol 6:93–100PubMedCrossRef

36.

Tan Y, Yu F, Yang H, Chen M, Fang Q, Zhao MH (2008) Autoantibodies against monomeric C-reactive protein in sera from patients with lupus nephritis are associated with disease activity and renal tubulointerstitial lesions. Hum Immunol 69:840–844PubMedCrossRef

37.

Schwedler SB, Guderian F, Dammrich J, Potempa LA, Wanner C (2003) Tubular staining of modified C-reactive protein in diabetic chronic kidney disease. Nephrol Dial Transplant 18:2300–2307PubMedCrossRef

38.

Clarkson MR, Giblin L, O’Connell FP, O’Kelly P, Walshe JJ, Conlon P, O’Meara Y, Dormon A, Campbell E, Donohoe J (2004) Acute interstitial nephritis: clinical features and response to corticosteroid therapy. Nephrol Dial Transplant 19:2778–2783PubMedCrossRef

39.

Gordillo G, Ramirez M, Mota F (1981) Acute non-bacterial interstitial tubular nephritis. Bol Méd Hosp Infant Méx 38:259–267PubMed

40.

Igarashi T, Kawato H, Kamoshita S, Nosaka K, Seiya K, Hayakawa H (1992) Acute tubulointerstitial nephritis with uveitis syndrome presenting as multiple tubular dysfunction including Fanconi’s syndrome. Pediatr Nephrol 6:547–549PubMedCrossRef

41.

Watanabe T, Yoshikawa H, Yamazaki S, Abe Y, Abe T (2005) Secondary renal Fanconi syndrome caused by valproate therapy. Pediatr Nephrol 20:814–817PubMedCrossRef

42.

Joh K, Aizawa S, Yamaguchi Y, Inomata I, Shibasaki T, Sakai O, Hamaguchi K (1990) Drug-induced hypersensitivity nephritis: lymphocyte stimulation testing and renal biopsy in 10 cases. Am J Nephrol 10:222–230PubMedCrossRef

43.

Mori Y, Kishimoto N, Yamahara H, Kijima Y, Nose A, Uchiyama-Tanaka Y, Fukui M, Kitamura T, Tokoro T, Masaki H, Nagata T, Umeda Y, Nishikawa M, Iwasaka T (2005) Predominant tubulointerstitial nephritis in a patient with systemic lupus nephritis. Clin Exp Nephrol 9:79–84PubMedCrossRef

44.

Mackensen F, Smith JR, Rosenbaum JT (2007) Enhanced recognition, treatment, and prognosis of tubulointerstitial nephritis and uveitis syndrome. Ophthalmology 114:995–999PubMedCrossRef

45.

Thomassen VH, Ring T, Thaarup J, Baggesen K (2009) Tubulointerstitial nephritis and uveitis (TINU) syndrome: a case report and review of the literature. Acta Ophthalmol 87:676–679PubMedCrossRef

46.

Vohra S, Eddy A, Levin AV, Taylor G, Laxer RM (1999) Tubulointerstitial nephritis and uveitis in children and adolescents. Four new cases and a review of the literature. Pediatr Nephrol 13:426–432PubMedCrossRef

47.

Jahnukainen T, Ala-Houhala M, Karikoski R, Kataja J, Saarela V, Nuutinen M (2011) Clinical outcome and occurrence of uveitis in children with idiopathic tubulointerstitial nephritis. Pediatr Nephrol 26:291–299PubMedCrossRef

48.

Sanchez-Burson J, Garcia-Porrua C, Montero-Granados R, Gonzalez-Escribano F, Gonzalez-Gay MA (2002) Tubulointerstitial nephritis and uveitis syndrome in Southern Spain. Semin Arthritis Rheum 32:125–129PubMedCrossRef

49.

Dusek J, Urbanova I, Stejskal J, Seeman T, Vondrak K, Janda J (2008) Tubulointerstitial nephritis and uveitis syndrome in a mother and her son. Pediatr Nephrol 23:2091–2093PubMedCrossRef

50.

Mandeville JT, Levinson RD, Holland GN (2001) The tubulointerstitial nephritis and uveitis syndrome. Surv Ophthalmol 46:195–208PubMedCrossRef

51.

Levinson RD, Park MS, Rikkers SM, Reed EF, Smith JR, Martin TM, Rosenbaum JT, Foster CS, Sherman MD, Holland GN (2003) Strong associations between specific HLA-DQ and HLA-DR alleles and the tubulointerstitial nephritis and uveitis syndrome. Invest Ophthalmol Vis Sci 44:653–657PubMedCrossRef

52.

Levinson RD (2008) Tubulointerstitial nephritis and uveitis syndrome. Int Ophthalmol Clin 48:51–59PubMedCrossRef

53.

Joss N, Morris S, Young B, Geddes C (2007) Granulomatous interstitial nephritis. Clin J Am Soc Nephrol 2:222–230PubMedCrossRef

54.

Hirano K, Tomino Y, Mikami H, Ota K, Aikawa Y, Shirato I, Koide H (1989) A case of acute tubulointerstitial nephritis and uveitis syndrome with a dramatic response to corticosteroid therapy. Am J Nephrol 9:499–503PubMedCrossRef

55.

Baker RJ, Pusey CD (2004) The changing profile of acute tubulointerstitial nephritis. Nephrol Dial Transplant 19:8–11PubMedCrossRef

56.

Neilson EG (1989) Pathogenesis and therapy of interstitial nephritis. Kidney Int 35:1257–1270PubMedCrossRef

57.

Gallego N, Estepa R, Mampaso F, Garcia SF, Reche A, Ortuno J (2000) Tubulointerstitial nephritis and asymptomatic uveitis. J Nephrol 13:373–376PubMed

58.

Feinfeld DA, Ansari N, Nuovo M, Hussain A, Mir R (1999) Tubulointerstitial nephritis associated with minimal self reexposure to rifampin. Am J Kidney Dis 33:e3PubMedCrossRef

59.

Gonzalez E, Gutierrez E, Galeano C, Chevia C, de Sequera P, Bernis C, Parra EG, Delgado R, Sanz M, Ortiz M, Goicoechea M, Quereda C, Olea T, Bouarich H, Hernandez Y, Segovia B, Praga M (2008) Early steroid treatment improves the recovery of renal function in patients with drug-induced acute interstitial nephritis. Kidney Int 73:940–946PubMedCrossRef

60.

Preddie DC, Markowitz GS, Radhakrishnan J, Nickolas TL, D’Agati VD, Schwimmer JA, Gardenswartz M, Rosen R, Appel GB (2006) Mycophenolate mofetil for the treatment of interstitial nephritis. Clin J Am Soc Nephrol 1:718–722PubMedCrossRef

61.

Gion N, Stavrou P, Foster CS (2000) Immunomodulatory therapy for chronic tubulointerstitial nephritis-associated uveitis. Am J Ophthalmol 129:764–768PubMedCrossRef

62.

Zuliani E, Zwahlen H, Gilliet F, Marone C (2005) Vancomycin-induced hypersensitivity reaction with acute renal failure: resolution following cyclosporine treatment. Clin Nephrol 64:155–158PubMed

63.

Tynjala P, Lindahl P, Honkanen V, Lahdenne P, Kotaniemi K (2007) Infliximab and etanercept in the treatment of chronic uveitis associated with refractory juvenile idiopathic arthritis. Ann Rheum Dis 66:548–550PubMedCrossRef

64.

Ellis D, Fried WA, Yunis EJ, Blau EB (1981) Acute interstitial nephritis in children: a report of 13 cases and review of the literature. Pediatrics 67:862–870PubMed

65.

Schwarz A, Krause PH, Kunzendorf U, Keller F, Distler A (2000) The outcome of acute interstitial nephritis: risk factors for the transition from acute to chronic interstitial nephritis. Clin Nephrol 54:179–190PubMed

66.

Ivanyi B, Hamilton-Dutoit SJ, Hansen HE, Olsen S (1996) Acute tubulointerstitial nephritis: phenotype of infiltrating cells and prognostic impact of tubulitis. Virchows Arch 428:5–12PubMedCrossRef

Title: Acute tubulointerstitial nephritis
Authors: Tim Ulinski
Anne-Laure Sellier-Leclerc
Elena Tudorache
Albert Bensman
Bilal Aoun
Publication date: 01-07-2012
Publisher: Springer-Verlag
Published in: Pediatric Nephrology / Issue 7/2012
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-011-1915-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Acute tubulointerstitial nephritis

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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