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01-03-2021 | Acute Respiratory Distress-Syndrome | Correspondence

Ten reasons why corticosteroid therapy reduces mortality in severe COVID-19

Authors: José M. Añón, Jesús Villar

Published in: Intensive Care Medicine | Issue 3/2021

Excerpt

We have read with interest the recent article by Arabi et al. [1] published in Intensive Care Medicine where the authors provided 10 reasons why corticosteroid therapy reduces mortality in severe coronavirus disease 2019 (COVID-19). The authors stated that the best available evidence to support the use of corticosteroids in COVID-19 is based on the results of the RECOVERY trial [2] and the WHO REACT prospective meta-analysis [3]. They mentioned the DEXA-ARDS trial [4] where dexamethasone, (20 mg and 10 mg for 5 days each) markedly decreased 60-day mortality in mechanically ventilated patients with persistent moderate-to-severe acute respiratory distress syndrome (ARDS). …

Arabi YM, Chrousos GP, Meduri GU (2020) The ten reasons why corticosteroid therapy reduces mortality in severe COVID-19. Intensive Care Med 46:2067–2070CrossRef

RECOVERY Collaborative Group, Horby P, Lim WS, Emberson JR, Mafham M, Bell JL, Linsell L, Staplin N, Brightling C, Ustianowski A, Elmahi E, Prudon B, Green C, Felton T, Chadwick D, Rege K, Fegan C, Chappell LC, Faust SN, Jaki T, Jeffery K, Montgomery A, Rowan K, Juszczak E, Baillie JK, Haynes R, Landray MJ (2020) Dexamethasone in hospitalized patients with Covid-19—preliminary report. N Engl J Med. https://doi.org/10.1056/NEJMoa2021436CrossRef

WHO React Working Group, Sterne JAC, Murthy S, Diaz JV, Slutsky AS, Villar J, Angus DC, Annane D, Azevedo LCP, Berwanger O, Cavalcanti AB, Dequin PF, Du B, Emberson J, Fisher D, Giraudeau B, Gordon AC, Granholm A, Green C, Haynes R, Heming N, Higgins JPT, Horby P, Juni P, Landray MJ, Le Gouge A, Leclerc M, Lim WS, Machado FR, McArthur C, Meziani F, Moller MH, Perner A, Petersen MW, Savovic J, Tomazini B, Veiga VC, Webb S, Marshall JC (2020) Association between administration of systemic corticosteroids and mortality among critically ill patients with COVID-19: a meta-analysis. JAMA 324:1330–1341CrossRef

Villar J, Ferrando C, Martínez D, Ambrós A, Muñoz T, Soler JA, Aguilar G, Alba F, González-Higueras E, Conesa LA, Martín-Rodríguez C, Díaz-Domínguez FJ, Serna-Grande P, Rivas R, Ferreres J, Belda J, Capilla L, Tallet A, Añón JM, Fernández RL, González-Martín JM, Dexamethasone in ARDS network (2020) Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial. Lancet Respir Med 8:267–276CrossRef

Mongardon N, Piagnerelli M, Grimaldi D, Perrot B, Lascarrou JB, COVADIS study group investigators (2020) Impact of late administration of corticosteroids in COVID-19 ARDS. Intensive Care Med. https://doi.org/10.1007/s00134-020-06311-zCrossRefPubMedPubMedCentral

Title: Ten reasons why corticosteroid therapy reduces mortality in severe COVID-19
Authors: José M. Añón
Jesús Villar
Publication date: 01-03-2021
Publisher: Springer Berlin Heidelberg
Keywords: Acute Respiratory Distress-Syndrome
COVID-19
Dexamethasone
Published in: Intensive Care Medicine / Issue 3/2021
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-020-06330-w

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Ten reasons why corticosteroid therapy reduces mortality in severe COVID-19

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