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09-11-2023 | Acute Pancreatitis | Original Article

Etiological Changes and Prognosis of Hospitalized Patients with Acute Pancreatitis Over a 15-Year Period

Authors: Tianming Lai, Jiarong Li, Zhengang Zhou, Jingwen Rao, Yong Zhu, Liang Xia, Yupeng Lei, Xin Huang, Huajing Ke, Yao Wu, Pi Liu, Hao Zeng, Huifang Xiong, Lingyu Luo, Youxiang Chen, Wenhua He, Yin Zhu, Nonghua Lu

Published in: Digestive Diseases and Sciences | Issue 1/2024

Abstract

Background

The worldwide incidence of acute pancreatitis (AP) is increasing, but the dominant etiology of AP may vary by country. Mixed etiologies are involved in the increase in the number of AP patients.

Aims

This study was to analyze the etiological changes and prognosis of AP patients and explore the prognosis of AP patients with mixed etiologies.

Methods

Using a retrospective analysis method, AP patients hospitalized from January 2007 to December 2021 were selected from a pancreatic center in Nanchang, China. Trends in the main etiologies were analyzed, and the severity and prognosis of different etiologies were compared.

Results

A total of 10,071 patients were included. Cholelithiasis (56.0%), hyperlipidemia (25.3%), and alcohol (6.5%) were the top three etiologies. The proportion of acute biliary pancreatitis (ABP) showed a decreasing trend, while the proportion of hypertriglyceridemic pancreatitis (HTGP) and alcoholic AP showed an increasing trend (all p_trend < 0.001). The incidence of organ failure and necrotizing pancreatitis was higher in patients with HTGP than in those with AP induced by other etiologies (all p < 0.05). There was no statistically significant difference in mortality among patients with different etiologies. Patients with AP due to a mixed hypertriglyceridemia-alcoholic etiology had higher ICU admission rates and were more severe than those with AP induced by other mixed etiologies.

Conclusion

In the past 15 years, the proportion of ABP has trended downward, while those of HTGP and alcoholic AP have risen. Among patients with mixed etiologies, those with a mixed hypertriglyceridemia-alcoholic etiology had a worse prognosis.

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Title: Etiological Changes and Prognosis of Hospitalized Patients with Acute Pancreatitis Over a 15-Year Period
Authors: Tianming Lai
Jiarong Li
Zhengang Zhou
Jingwen Rao
Yong Zhu
Liang Xia
Yupeng Lei
Xin Huang
Huajing Ke
Yao Wu
Pi Liu
Hao Zeng
Huifang Xiong
Lingyu Luo
Youxiang Chen
Wenhua He
Yin Zhu
Nonghua Lu
Publication date: 09-11-2023
Publisher: Springer US
Keywords: Acute Pancreatitis
Pancreatitis
Cholelithiasis
Published in: Digestive Diseases and Sciences / Issue 1/2024
Print ISSN: 0163-2116
Electronic ISSN: 1573-2568
DOI: https://doi.org/10.1007/s10620-023-08172-0

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