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International Journal of Colorectal Disease

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01-12-2023 | Acute Pancreatitis | RESEARCH

Efficacy and safety of early enteral and intravenous fluid resuscitation in severe acute pancreatitis: a systematic review and meta-analysis

Authors: Jiao Liu, Huifang Qiu, Yanfang Yuan, Chengjiang Liu, Shaojian Mo, Fang He, Xifeng Fu

Published in: International Journal of Colorectal Disease | Issue 1/2023

Abstract

Objective

To compare the efficacy and safety of enteral fluid resuscitation (via nasointestinal tube or colorectal tube) and intravenous fluid resuscitation (via intravenous route) in the early treatment of severe acute pancreatitis.

Methods

In this study, 8 electronic databases (PubMed, Web of Science, Embase, Cochrane Library, Scopus, China HowNet database, Wanfang database, and VIP database) were searched to collect clinical studies from inception to June 12, 2022. After the quality evaluation and data extraction of the included studies, the RevMan 5.3 software was used for analysis.

Results

A total of seven studies including 580 patients were studied in this meta-analysis, in which 291 cases were treated with enteral fluid resuscitation and 289 cases were treated with intravenous fluid resuscitation. Compared with the intravenous route group, the enteral route resuscitation group reduced the incidence of new organ failure (OR = 0.23, 95% CI: 0.12–0.43, P < 0.00001), the incidence of persistent organ failure (OR = 0.38, 95% CI: 0.22–0.64, P = 0.0003), the incidence of mechanical ventilation (OR = 0.15, 95% CI: 0.03–0.69, P = 0.01), the incidence of ICU care (OR = 0.49, 95% CI: 0.27–0.88, P = 0.02), and the incidence of pancreatic infection (OR = 0.38, 95% CI: 0.17–0.83, P = 0.02). There were no statistically significant differences in mortality (OR = 0.77, 95% CI: 0.35–1.66, P = 0.50), surgical intervention rate (OR = 0.47, 95% CI: 0.19–1.18, P = 0.11), and incidence of localized ascites (OR = 0.65, 95% CI: 0.25–1.73, P = 0.39).

Conclusion

Early enteral fluid resuscitation is safe and effective for in severe pancreatitis. But this conclusion needs to be verified by more additional multi-centre randomized controlled trials with large samples.

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Title: Efficacy and safety of early enteral and intravenous fluid resuscitation in severe acute pancreatitis: a systematic review and meta-analysis
Authors: Jiao Liu
Huifang Qiu
Yanfang Yuan
Chengjiang Liu
Shaojian Mo
Fang He
Xifeng Fu
Publication date: 01-12-2023
Publisher: Springer Berlin Heidelberg
Keywords: Acute Pancreatitis
Pancreatitis
Published in: International Journal of Colorectal Disease / Issue 1/2023
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-023-04335-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Efficacy and safety of early enteral and intravenous fluid resuscitation in severe acute pancreatitis: a systematic review and meta-analysis

Abstract

Objective

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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