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Oral and Maxillofacial Surgery
Published in: Oral and Maxillofacial Surgery 1/2020

01-03-2020 | Acute Myeloid Leukemia | Case Report

A case of myeloid sarcoma of the mandibular gingiva as extramedullary relapse of acute myeloid leukemia

Authors: Shigeo Ishikawa, Yuichi Kato, Takanobu Kabasawa, Chiho Yoshioka, Kenichiro Kitabatake, Mitsunori Yamakawa, Kenichi Ishizawa, Mitsuyoshi Iino

Published in: Oral and Maxillofacial Surgery | Issue 1/2020

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Abstract

Purpose

Myeloid sarcoma (MS) is defined as a tumorous mass of myeloblasts or immature myeloid cells involving an extramedullary anatomic site. MS occurs in 3 to 8% of patients with acute myeloid leukemia. The overwhelming majority of MS occurs in the skin, bones, and gastrointestinal tract; intraoral MS (IMS) is extremely rare.

Methods

We describe a case of MS of the mandibular gingiva in a patient with acute myeloid leukemia that was in remission. We also present a review of the English and Japanese literature with a special focus on the management and prognosis of intraoral MS.

Results

The patient was discharged while in remission 8 months after the initial examination.

Conclusion

The prognosis of IMS is extremely poor in general, and a diagnostic delay can prevent adequate therapy by hematologists and oncologists. All dental clinicians must keep the possibility of IMS in mind and carefully examine all patients with AML.
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Metadata
Title
A case of myeloid sarcoma of the mandibular gingiva as extramedullary relapse of acute myeloid leukemia
Authors
Shigeo Ishikawa
Yuichi Kato
Takanobu Kabasawa
Chiho Yoshioka
Kenichiro Kitabatake
Mitsunori Yamakawa
Kenichi Ishizawa
Mitsuyoshi Iino
Publication date
01-03-2020
Publisher
Springer Berlin Heidelberg
Published in
Oral and Maxillofacial Surgery / Issue 1/2020
Print ISSN: 1865-1550
Electronic ISSN: 1865-1569
DOI
https://doi.org/10.1007/s10006-019-00812-y

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