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10-06-2022 | Acute Myeloid Leukemia | Leukemia (PH Wiernik, Section Editor)

How Genetics Can Drive Initial Therapy Choices for Older Patients with Acute Myeloid Leukemia

Authors: Jozal W. Moore, MD, Nancy Torres, MD, Michael Superdock, MD, Jason H. Mendler, MD, PhD, Kah Poh Loh, MBBCh BAO, MS

Published in: Current Treatment Options in Oncology | Issue 8/2022

Opinion statement

Treatment of older adults with acute myeloid leukemia (AML) is challenging. Therapy decisions must be guided by multiple factors including aging-related conditions (e.g., comorbidities, functional impairment), therapy benefits and risks, patient preferences, and disease characteristics. Balancing these factors requires understanding the unique, and frequently higher-risk cytogenetic and molecular characteristics of AML in older adult populations, which should caution providers not to reduce therapy intensity on the basis of age alone. Instead, geriatric assessments should be employed to determine fitness for therapy. Treatment options in AML are increasingly targeted to specific mutations or recognized to have differential benefits on the basis of genomics, and representation of older adults and geriatric outcome reporting in clinical trials is improving. Additionally, newer studies have begun to explore personalized therapy strategies on the basis of initial genetic testing. Review and refinement of practice guidelines for older patients on the basis of these advances is needed and is anticipated to remain an important topic in ongoing hematology/oncology clinical education.

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•• Bhatt VR, Wichman C, Al-Kadhimi ZS, Koll TT, Fisher AL, Mahato RI, et al. Integrating geriatric assessment and genetic profiling to personalize therapy selection in older adults with acute myeloid leukemia. J Geriatr Oncol. 2022. 10.1016/j.jgo.2022.04.005. Feasibility of combination of geriatric and genetic assessments to guide therapy for older adults with AML.

Title: How Genetics Can Drive Initial Therapy Choices for Older Patients with Acute Myeloid Leukemia
Authors: Jozal W. Moore, MD
Nancy Torres, MD
Michael Superdock, MD
Jason H. Mendler, MD, PhD
Kah Poh Loh, MBBCh BAO, MS
Publication date: 10-06-2022
Publisher: Springer US
Keywords: Acute Myeloid Leukemia
Hematology
Published in: Current Treatment Options in Oncology / Issue 8/2022
Print ISSN: 1527-2729
Electronic ISSN: 1534-6277
DOI: https://doi.org/10.1007/s11864-022-00991-z

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