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Open Access 01-12-2022 | Acute Myeloid Leukemia | Review

A review on the role of LINC00467 in the carcinogenesis

Authors: Soudeh Ghafouri-Fard, Tayyebeh Khoshbakht, Bashdar Mahmud Hussen, Mohammad Taheri, Mohammadreza Hajiesmaeili

Published in: Cancer Cell International | Issue 1/2022

Abstract

LINC00467 is an example of long intergenic non-coding RNAs whose roles in human disorders are being identified. This gene coding LINC00467 is located on chromosome 1: 211,382,736 − 211,435,570 forward strand. This lncRNA has been firstly recognized through a microarray-based lncRNA profiling as an N-Myc target in neuroblastoma cells. Further studies have shown up-regulation of LINC00467 in different cancer including those originated from brain, gastrointestinal tract, lung and breast. It acts as a molecular sponge for miR-339, miR-138-5p, miR-107, miR-133b, miR-451a, miR-485-5p, miR-7-5p, miR-485-5p, miR-339-3p, miR-200a, miR-1285-3p, miR-299-5p, miR-509-3p, miR-18a-5p, miR-9-5p and miR-20b-5p. LINC00467 can regulate activity of NF-κB, STAT1, Wnt/b-catenin, Akt and ERK1/2 signaling pathways. Accumulating evidence indicates oncogenic role of LINC00467. The current review article aims at providing an overview of LINC00467 in the carcinogenesis.

Zhang X, Wang W, Zhu W, Dong J, Cheng Y, Yin Z, et al. Mechanisms and Functions of Long Non-Coding RNAs at Multiple Regulatory Levels. Int J Mol Sci. 2019;20(22):5573. PubMed PMID: 31717266. eng.PubMedCentralCrossRef

Statello L, Guo C-J, Chen L-L, Huarte M. Gene regulation by long non-coding RNAs and its biological functions. Nat Rev Mol Cell Biol. 2021;22(2):96–118.PubMedCrossRef

Derrien T, Johnson R, Bussotti G, Tanzer A, Djebali S, Tilgner H, et al. The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome Res. 2012;22(9):1775–89.PubMedPubMedCentralCrossRef

Atmadibrata B, Liu PY, Sokolowski N, Zhang L, Wong M, Tee AE, et al. The novel long noncoding RNA linc00467 promotes cell survival but is down-regulated by N-Myc. PLoS ONE. 2014;9(2):e88112.PubMedPubMedCentralCrossRef

Lu J, Wu X, Wang L, Li T, Sun L. Long noncoding RNA LINC00467 facilitates the progression of acute myeloid leukemia by targeting the miR-339/SKI pathway. Leuk Lymphoma. 2021;62(2):428–37.PubMedCrossRef

Zhang Y, Sun Y, Ding L, Shi W, Ding K, Zhu Y. Long non-coding RNA LINC00467 correlates to poor prognosis and aggressiveness of breast cancer. Frontiers in oncology. 2021;11.

Bo H, Zhang W, Zhong X, Chen J, Liu Y, Cheong K-L, et al. LINC00467, Driven by Copy Number Amplification and DNA Demethylation, Is Associated with Oxidative Lipid Metabolism and Immune Infiltration in Breast Cancer. Oxidative medicine and cellular longevity. 2021;2021.

Li G-C, Xin L, Wang Y-S, Chen Y. Long intervening noncoding 00467 RNA contributes to tumorigenesis by acting as a competing endogenous RNA against miR-107 in cervical cancer cells. Am J Pathol. 2019;189(11):2293–310.PubMedCrossRef

Chen Y, Ding Y. LINC00467 enhances head and neck squamous cell carcinoma progression and the epithelial–mesenchymal transition process via miR-299‐5p/ubiquitin specific protease‐48 axis. J Gene Med. 2020;22(7):e3184.PubMedCrossRef

10.

Li W, He Y, Chen W, Man W, Fu Q, Tan H, et al. Knockdown of LINC00467 contributed to Axitinib sensitivity in hepatocellular carcinoma through miR-509-3p/PDGFRA axis. Gene Ther. 2021;28(10):634–45.PubMedCrossRef

11.

Zheng Y, Nie P, Xu S. Long noncoding RNA linc00467 plays an oncogenic role in hepatocellular carcinoma by regulating the miR-18a‐5p/NEDD9 axis. J Cell Biochem. 2020;121(5–6):3135–44.PubMedCrossRef

12.

Cai K, Li T, Guo L, Guo H, Zhu W, Yan L, et al. Long non-coding RNA LINC00467 regulates hepatocellular carcinoma progression by modulating miR-9-5p/PPARA expression. Open biology. 2019;9(9):190074.PubMedPubMedCentralCrossRef

13.

Yan J, Fang T, Zhang M, Zhou Q. LINC00467 facilitates osteosarcoma progression by sponging miR–217 to regulate KPNA4 expression. Int J Mol Med. 2021;47(3):1-.CrossRef

14.

Ma H, Wang J, Shi J, Zhang W, Zhou D. LncRNA LINC00467 contributes to osteosarcoma growth and metastasis through regulating HMGA1 by directly targeting miR-217. Eur Rev Med Pharmacol Sci. 2020;24(11):5933–45.PubMed

15.

Ding H, Luo Y, Hu K, Liu P, Xiong M. Linc00467 promotes lung adenocarcinoma proliferation via sponging miR-20b-5p to activate CCND1 expression. OncoTargets and therapy. 2019;12:6733.PubMedPubMedCentralCrossRef

16.

Chang Y, Yang L. LINC00467 promotes cell proliferation and stemness in lung adenocarcinoma by sponging miR-4779 and miR‐7978. J Cell Biochem. 2020;121(8–9):3691–9.CrossRef

17.

Xiao J, Gong L, Xiao M, He D, Xiang L, Wang Z, et al. LINC00467 Promotes Tumor Progression via Regulation of the NF-kb Signal Axis in Bladder Cancer. Front Oncol. 2021;11:1958.CrossRef

18.

He X, Li S, Yu B, Kuang G, Wu Y, Zhang M, et al. Up-regulation of LINC00467 promotes the tumourigenesis in colorectal cancer. J Cancer. 2019;10(25):6405.PubMedPubMedCentralCrossRef

19.

Liang Y, Cheng G, Huang D, Yuan F. Linc00467 promotes invasion and inhibits apoptosis of head and neck squamous cell carcinoma by regulating miR-1285-3p/TFAP2A. Am J Translational Res. 2021;13(6):6248.

20.

Jiang W, Cheng X, Wang T, Song X, Zheng Y, Wang L. LINC00467 promotes cell proliferation and metastasis by binding with IGF2BP3 to enhance the mRNA stability of TRAF5 in hepatocellular carcinoma. J Gene Med. 2020;22(3):e3134.PubMedCrossRef

21.

Han Y, Cai Y, Lai X, Wang Z, Wei S, Tan K, et al. lncRNA RMRP Prevents Mitochondrial Dysfunction and Cardiomyocyte Apoptosis via the miR-1-5p/hsp70 Axis in LPS-Induced Sepsis Mice. Inflammation. 2020:1–14.

22.

Bai Y, Wu H, Han B, Xu K, Liu Y, Liu Y, et al. Long intergenic non–protein coding RNA–467 targets microRNA–451a in human colorectal cancer. Oncol Lett. 2020;20(5):1-.CrossRef

23.

Liu Z, Yang S, Chen X, Dong S, Zhou S, Xu S. LncRNA LINC00467 acted as an oncogene in esophageal squamous cell carcinoma by accelerating cell proliferation and preventing cell apoptosis via the miR-485‐5p/DPAGT1 axis. J Gastroenterol Hepatol. 2021;36(3):721–30.PubMedCrossRef

24.

Deng L-H, Zhao H, Bai L-P, Xie J, Liu K, Yan F. Linc00467 promotion of gastric cancer development by directly regulating miR-7-5p expression and downstream epidermal growth factor receptor. Bioengineered. 2021;12(2):9484–95.PubMedPubMedCentralCrossRef

25.

Xu L, Liu C, Ye Z, Wu C, Ding Y, Huang J. Overexpressed LINC00467 promotes the viability and proliferation yet inhibits apoptosis of gastric cancer cells via raising ITGB3 level. Tissue Cell. 2021;73:101644.PubMedCrossRef

26.

Jiang X, Liu Y. LINC00467 promotes proliferation and invasion in glioma via interacting with miRNA-485-5p. Eur Rev Med Pharmacol Sci. 2020;24:766–72.PubMed

27.

Zhang Y, Zhang Y, Wang S, Cao B, Hu D, Jia J, et al. LINC00467 facilitates the proliferation, migration and invasion of glioma via promoting the expression of inositol hexakisphosphate kinase 2 by binding to miR-339-3p. Bioengineered. 2022;13(2):3370–82.PubMedPubMedCentralCrossRef

28.

Zhang Y, Jiang X, Wu Z, Hu D, Jia J, Guo J, et al. Long noncoding RNA LINC00467 promotes glioma progression through inhibiting P53 expression via binding to DNMT1. J Cancer. 2020;11(10):2935.PubMedPubMedCentralCrossRef

29.

Gao S, Duan H, An D, Yi X, Li J, Liao C. Knockdown of long non-coding RNA LINC00467 inhibits glioma cell progression via modulation of E2F3 targeted by miR-200a. Cell Cycle. 2020;19(16):2040–53.PubMedPubMedCentralCrossRef

30.

Liang R, Tang Y. LINC00467 knockdown repressed cell proliferation but stimulated cell apoptosis in glioblastoma via miR-339-3p/IP6K2 axis. Cancer Biomarkers. 2020;28(2):169–80.PubMedCrossRef

31.

Wang H, Guo Q, Nampoukime KPB, Yang P, Ma K. Long non-coding RNA LINC00467 drives hepatocellular carcinoma progression via inhibiting NR4A3. J Cell Mol Med. 2020;24(7):3822–36.PubMedPubMedCentralCrossRef

32.

Yang J, Liu Y, Mai X, Lu S, Jin L, Tai X. STAT1-induced upregulation of LINC00467 promotes the proliferation migration of lung adenocarcinoma cells by epigenetically silencing DKK1 to activate Wnt/β-catenin signaling pathway. Biochem Biophys Res Commun. 2019;514(1):118–26.PubMedCrossRef

33.

Wang X, Liu H, Shen K, Pan X, Wei Y, Lv T, et al. Long intergenic non–coding RNA 00467 promotes lung adenocarcinoma proliferation, migration and invasion by binding with EZH2 and repressing HTRA3 expression. Mol Med Rep. 2019;20(1):640–54.PubMedPubMedCentral

34.

Zhu Y, Li J, Bo H, He D, Xiao M, Xiang L, et al. LINC00467 is up-regulated by TDG-mediated acetylation in non-small cell lung cancer and promotes tumor progression. Oncogene. 2020;39(38):6071–84.PubMedCrossRef

35.

Xue F, Yang C, Yun K, Jiang C, Cai R, Liang M, et al. Reduced LINC00467 elevates microRNA-125a-3p to suppress cisplatin resistance in non-small cell lung cancer through inhibiting sirtuin 6 and inactivating the ERK1/2 signaling pathway. Cell Biology and Toxicology. 2021:1–17.

36.

Jiang H, Deng W, Zhu K, Zeng Z, Hu B, Zhou Z, et al. LINC00467 promotes prostate cancer progression via M2 macrophage polarization and the miR-494-3p/STAT3 axis. Front Oncol. 2021;11:1688.

37.

Bo H, Zhu F, Liu Z, Deng Q, Liu G, Li R, et al. Integrated analysis of high-throughput sequencing data reveals the key role of LINC00467 in the invasion and metastasis of testicular germ cell tumors. Cell Death Discovery. 2021;7(1):1–12.CrossRef

38.

Wang W, Bo H, Liang Y, Li G. LINC00467 Is Upregulated by DNA Copy Number Amplification and Hypomethylation and Shows ceRNA Potential in Lung Adenocarcinoma. Frontiers in endocrinology. 2021;12.

Title: A review on the role of LINC00467 in the carcinogenesis
Authors: Soudeh Ghafouri-Fard
Tayyebeh Khoshbakht
Bashdar Mahmud Hussen
Mohammad Taheri
Mohammadreza Hajiesmaeili
Publication date: 01-12-2022
Publisher: BioMed Central
Keyword: Acute Myeloid Leukemia
Published in: Cancer Cell International / Issue 1/2022
Electronic ISSN: 1475-2867
DOI: https://doi.org/10.1186/s12935-022-02724-6

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