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01-10-2012 | Leukemia (A Aguayo, Section Editor)

Acute Myeloid Leukemia with Normal Cytogenetics

Authors: Raya Mawad, Elihu H. Estey

Published in: Current Oncology Reports | Issue 5/2012

Abstract

Acute myeloid leukemia (AML) is proving to be a heterogeneous disease process that is driven by various genetic mutations and aberrant protein expression. As our population ages, the incidence of AML is likely to increase, with approximately a third of adult cases categorized with normal cytogenetics. Advances in technology are now allowing us to explore the genetic expression and protein transcription patterns of AML, providing more information that must find its place in the prognosis and the therapeutic algorithm of this disease. As we learn more, we hope to further categorize patients with normal karyotype AML into discrete risk categories that will help in treatment decision making and further elucidate the necessity for hematopoietic cell transplantation. However, at this time, many of the identified mutations and expression patterns are still experimental, requiring further analysis to determine their exact role in AML.

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Title: Acute Myeloid Leukemia with Normal Cytogenetics
Authors: Raya Mawad
Elihu H. Estey
Publication date: 01-10-2012
Publisher: Current Science Inc.
Published in: Current Oncology Reports / Issue 5/2012
Print ISSN: 1523-3790
Electronic ISSN: 1534-6269
DOI: https://doi.org/10.1007/s11912-012-0252-x

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Keynote webinar | Spotlight on antibody–drug conjugates in cancer

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Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras

Prof. Fabrice Barlesi

Developed by: Springer Medicine

Keynote webinar | Spotlight on medication adherence

Springer Medicine

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Other articles of this Issue 5/2012

B-Cell Receptor Pathobiology and Targeting in NHL

Driver Mutations in Melanoma: Lessons Learned From Bench-to-Bedside Studies

Diagnosis of Acute Leukemia in Cerebrospinal Fluid (CSF-Acute Leukemia)

Philadelphia-Positive Acute Lymphoblastic Leukemia: Current Treatment Options

NK/T-Cell Lymphomas: Pathobiology, Prognosis and Treatment Paradigm

PET/CT Adapted Therapy in Hodgkin Disease: Current State of the Art and Future Directions

Keynote webinar | Spotlight on antibody–drug conjugates in cancer