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Critical Care
Published in: Critical Care 1/2018

Open Access 01-12-2018 | Viewpoint

Acute lung injury: how to stabilize a broken lung

Authors: Gary F. Nieman, Penny Andrews, Joshua Satalin, Kailyn Wilcox, Michaela Kollisch-Singule, Maria Madden, Hani Aiash, Sarah J. Blair, Louis A. Gatto, Nader M. Habashi

Published in: Critical Care | Issue 1/2018

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Abstract

The pathophysiology of acute respiratory distress syndrome (ARDS) results in heterogeneous lung collapse, edema-flooded airways and unstable alveoli. These pathologic alterations in alveolar mechanics (i.e. dynamic change in alveolar size and shape with each breath) predispose the lung to secondary ventilator-induced lung injury (VILI). It is our viewpoint that the acutely injured lung can be recruited and stabilized with a mechanical breath until it heals, much like casting a broken bone until it mends. If the lung can be “casted” with a mechanical breath, VILI could be prevented and ARDS incidence significantly reduced.
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Metadata
Title
Acute lung injury: how to stabilize a broken lung
Authors
Gary F. Nieman
Penny Andrews
Joshua Satalin
Kailyn Wilcox
Michaela Kollisch-Singule
Maria Madden
Hani Aiash
Sarah J. Blair
Louis A. Gatto
Nader M. Habashi
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2018
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-018-2051-8

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