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Pediatric Nephrology

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05-05-2023 | Acute Kidney Injury | Original Article

Patient level factors increase risk of acute kidney disease in hospitalized children with acute kidney injury

Authors: Mital Patel, Christoph Hornik, Clarissa Diamantidis, David T Selewski, Rasheed Gbadegesin

Published in: Pediatric Nephrology | Issue 10/2023

Abstract

Background

Studies in adults have shown that persistent kidney dysfunction ≥7–90 days following acute kidney injury (AKI), termed acute kidney disease (AKD), increases chronic kidney disease (CKD) and mortality risk. Little is known about the factors associated with the transition of AKI to AKD and the impact of AKD on outcomes in children. The aim of this study is to evaluate risk factors for progression of AKI to AKD in hospitalized children and to determine if AKD is a risk factor for CKD.

Methods

Retrospective cohort study of children age ≤18 years admitted with AKI to all pediatric units at a single tertiary-care children’s hospital between 2015 and 2019. Exclusion criteria included insufficient serum creatinine values to evaluate for AKD, chronic dialysis, or previous kidney transplant.

Results

A total of 528 children with AKI were included in the study. There were 297 (56.3%) hospitalized AKI survivors who developed AKD. Among children with AKD, 45.5% developed CKD compared to 18.7% in the group without AKD (OR 4.0, 95% CI 2.1–7.4, p-value <0.001 using multivariable logistic regression analysis including other covariates). Multivariable logistic regression model identified age at AKI diagnosis, PCICU and NICU admission, prematurity, malignancy, bone marrow transplant, previous AKI, mechanical ventilation, AKI stage, duration of kidney injury, and need for kidney replacement therapy during day 1–7 as risk factors for AKD after AKI.

Conclusions

AKD is common among hospitalized children with AKI and multiple risk factors are associated with AKD. Children that progress from AKI to AKD are at higher risk of developing CKD.

Graphical abstract

Available only for authorised users

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Title: Patient level factors increase risk of acute kidney disease in hospitalized children with acute kidney injury
Authors: Mital Patel
Christoph Hornik
Clarissa Diamantidis
David T Selewski
Rasheed Gbadegesin
Publication date: 05-05-2023
Publisher: Springer Berlin Heidelberg
Keywords: Acute Kidney Injury
Chronic Kidney Disease
Acute Kidney Injury
Published in: Pediatric Nephrology / Issue 10/2023
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-023-05997-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Patient level factors increase risk of acute kidney disease in hospitalized children with acute kidney injury

Abstract

Background

Methods

Results

Conclusions

Graphical abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

Graphical abstract

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