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Published in: Current Anesthesiology Reports 2/2019

01-06-2019 | Acute Kidney Injury | Critical Care Anesthesia (BS Rasmussen, Section Editor)

Renal Replacement Therapy in Critical Care: When to Start?

Authors: Morten H. Bestle, Theis Skovsgaard Itenov, Rasmus E. Berthelsen

Published in: Current Anesthesiology Reports | Issue 2/2019

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Abstract

Purpose of Review

Aside from absolute indications, the optimal timing of renal replacement therapy (RRT) in critical care is unknown. In this review, we discuss initiation of RRT in relation to both severity of acute kidney injury (AKI) and fluid accumulation.

Recent Findings

Results from studies of early vs. late RRT are conflicting, and no definitive conclusions have been made. Observational data points to fluid accumulation as a detrimental factor in critical illness and recent studies have shown that early fluid removal with RRT is feasible and could potentially improve survival.

Summary

There is a gap in the knowledge regarding when to initiate RRT in the absence of acute life-threatening complications. Recent studies of fluid accumulation in critically ill patients indicate the importance of avoiding fluid overload, and RRT might play an increasing role in the management of fluid balance in critical care.
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Metadata
Title
Renal Replacement Therapy in Critical Care: When to Start?
Authors
Morten H. Bestle
Theis Skovsgaard Itenov
Rasmus E. Berthelsen
Publication date
01-06-2019
Publisher
Springer US
Published in
Current Anesthesiology Reports / Issue 2/2019
Electronic ISSN: 2167-6275
DOI
https://doi.org/10.1007/s40140-019-00325-0

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