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Journal of Cardiothoracic Surgery

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Open Access 01-12-2021 | Acute Kidney Injury | Research article

The effect of N-acetyl cysteine injection on renal function after coronary artery bypass graft surgery: a randomized double blind clinical trial

Authors: Fatemeh Javaherforooshzadeh, Zahra Shaker, Mahboobeh Rashidi, Reza Akhondzadeh, Fatemeh Hayati

Published in: Journal of Cardiothoracic Surgery | Issue 1/2021

Abstract

Background

This study aimed to compare the effects of N-acetyl cysteine on renal function after coronary artery bypass graft surgery.

Methods

In this randomized clinical trial conducted in Golestan Hospital, Ahvaz, Iran, 60 candidates for coronary artery bypass graft surgery were selected and divided into two N-acetyl cysteine and control groups (30 people each). Patients received 3 (2 intraoperative and 1 postoperative) doses of IV N-acetyl cysteine (100 mg/kg) (n = 30) or placebo (n = 30) over 24 h. Prescription times were as follows: after induction of anesthesia, in the Next 4 h, and in the 16 h after on. Primary outcomes were serum levels of BUN and Cr, at baseline,4 and 48 h after surgery. And also need renal replacement therapy (RRT). Secondary outcomes included the hemodynamic variables, Blood products transfusion.

Results

There were significant differences in BUN between groups at 4 h (P = 0.02) and 48 h after surgery (P = 0.001) There were significant differences in Cr level between groups at 4 h (P < 0.001) and 48 h after surgery (P = 0.001).

MAP at different times (at 4 h p = 0.002 and 48 h after surgery P < 0.001) were significantly different between the two groups. There was a significant difference between the two groups in terms of the unit of Packed cell transfusion (P = 0.002) and FFP transfusion (P < 0.001).

Conclusion

In the present study, we found that administration of N-acetyl cysteine can reduce the incidence of acute kidney injury in patients undergoing coronary artery bypass graft surgery and improved kidney functions.

Trial registry

IRCT20190506043492N3 Registered at 2020.06.07.

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Title: The effect of N-acetyl cysteine injection on renal function after coronary artery bypass graft surgery: a randomized double blind clinical trial
Authors: Fatemeh Javaherforooshzadeh
Zahra Shaker
Mahboobeh Rashidi
Reza Akhondzadeh
Fatemeh Hayati
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Acute Kidney Injury
CABG
Acute Kidney Injury
CABG
Published in: Journal of Cardiothoracic Surgery / Issue 1/2021
Electronic ISSN: 1749-8090
DOI: https://doi.org/10.1186/s13019-021-01550-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The effect of N-acetyl cysteine injection on renal function after coronary artery bypass graft surgery: a randomized double blind clinical trial

Abstract

Background

Methods

Results

Conclusion

Trial registry

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

Trial registry

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