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Pediatric Nephrology
Published in: Pediatric Nephrology 5/2024

04-09-2023 | Acute Kidney Injury | Review

Caffeine and neonatal acute kidney injury

Authors: Kun Yang, Jinjing Liu, Ting He, Wenbin Dong

Published in: Pediatric Nephrology | Issue 5/2024

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Abstract

Acute kidney injury is one of the most threatening diseases in neonates, with complex pathogenesis and limited treatment options. Caffeine is a commonly used central nervous system stimulant for treating apnea in preterm infants. There is compelling evidence that caffeine may have potential benefits for preventing neonatal acute kidney injury, but comprehensive reports are lacking in this area. Hence, this review aims to provide a summary of clinical data on the potential benefits of caffeine in improving neonatal acute kidney injury. Additionally, it delves into the molecular mechanisms underlying caffeine’s effects on acute kidney injury, with a focus on various aspects such as oxidative stress, adenosine receptors, mitochondrial dysfunction, endoplasmic reticulum stress, inflammasome, autophagy, p53, and gut microbiota. The ultimate goal of this review is to provide information for healthcare professionals regarding the link between caffeine and neonatal acute kidney injury and to identify gaps in our current understanding.
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Metadata
Title
Caffeine and neonatal acute kidney injury
Authors
Kun Yang
Jinjing Liu
Ting He
Wenbin Dong
Publication date
04-09-2023
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 5/2024
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-023-06122-6

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