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Critical Care
Published in: Critical Care 4/2008

01-08-2008 | Letter

Acute kidney injury: time to shift from creatinine to the estimated glomerular filtration rate?

Authors: Giuseppe Lippi, Gian Cesare Guidi

Published in: Critical Care | Issue 4/2008

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Excerpt

Acute kidney injury (AKI) is a complex disorder for which currently there is no accepted definition. Although several groups are working on developing and validating biomarkers of kidney injury and the glomerular filtration rate (GFR), the proposed diagnostic criteria from the Acute Kidney Injury Network are based on an absolute increase in serum creatinine ≥ 0.3 mg/dl (≥ 26.4 μmol/l), a percentage increase in serum creatinine ≥ 50% (1.5-fold from baseline), or a reduction in urine output (documented oliguria < 0.5 ml/kg per hour for more than 6 hours) [1]. …
Literature
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Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, Levin A, Acute Kidney Injury Network: Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care 2007, 11: R31. 10.1186/cc5713PubMedCentralCrossRefPubMed
2.
Myers GL, Miller WG, Coresh J, Fleming J, Greenberg N, Greene T, Hostetter T, Levey AS, Panteghini M, Welch M, Eckfeldt JH, National Kidney Disease Education Program Laboratory Working Group: Recommendations for improving serum creatinine measurement: a report from the Laboratory Working Group of the National Kidney Disease Education Program. Clin Chem 2006, 52: 5-18. 10.1373/clinchem.2005.0525144CrossRefPubMed
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Poggio ED, Nef PC, Wang X, Greene T, Van Lente F, Dennis VW, Hall PM: Performance of the Cockcroft-Gault and modification of diet in renal disease equations in estimating GFR in ill hospitalized patients. Am J Kidney Dis 2005, 46: 242-252. 10.1053/j.ajkd.2005.04.023CrossRefPubMed
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Barrantes F, Tian J, Vazquez R, Amoateng-Adjepong Y, Manthous CA: Acute kidney injury criteria predict outcomes of critically ill patients. Crit Care Med 2008, 36: 1397-1403. 10.1097/CCM.0b013e318168fbe0CrossRefPubMed
5.
Ricci Z, Cruz D, Ronco C: The RIFLE criteria and mortality in acute kidney injury: a systematic review. Kidney Int 2008, 73: 538-546. 10.1038/sj.ki.5002743CrossRefPubMed
Metadata
Title
Acute kidney injury: time to shift from creatinine to the estimated glomerular filtration rate?
Authors
Giuseppe Lippi
Gian Cesare Guidi
Publication date
01-08-2008
Publisher
BioMed Central
Published in
Critical Care / Issue 4/2008
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc6936

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