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Published in: Neurological Sciences 4/2011

01-08-2011 | Case Report

Acute isolated ophthalmoplegia with anti-GQ1b antibodies

Authors: Andrea Rigamonti, Giuseppe Lauria, Marco Longoni, Lorenzo Stanzani, Elio Agostoni

Published in: Neurological Sciences | Issue 4/2011

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Abstract

Ophthalmoplegia without ataxia, areflexia or both has been designated as atypical Miller Fisher syndrome (MFS) or acute ophthalmoplegia (AO). This entity, first reported by Chiba et al. is associated with anti-GQ1b IgG antibodies.We report a patient with isolated acute ophthalmoplegia with high titer of anti-GQ1b IgG antibody activity in the acute phase in whom treatment with intravenous immunoglobulin (IVIg) led to the clinical recovery and the decrease in antibody titer.
Literature
1.
go back to reference Chiba A, Kusunoki S, Obata H, Machinami R, Kanazawa I (1993) Serum anti-GQ1b IgG antibody is associated with ophthalmoplegia in Miller Fisher syndrome and Guillain Barré syndrome: clinical and immunohistochemical studies. Neurology 43:1911–1917PubMed Chiba A, Kusunoki S, Obata H, Machinami R, Kanazawa I (1993) Serum anti-GQ1b IgG antibody is associated with ophthalmoplegia in Miller Fisher syndrome and Guillain Barré syndrome: clinical and immunohistochemical studies. Neurology 43:1911–1917PubMed
2.
go back to reference Yuki N (1996) Acute paresis of extraocular muscles associated with IgG anti-GQ1b antibody. Ann Neurol 39:668–672PubMedCrossRef Yuki N (1996) Acute paresis of extraocular muscles associated with IgG anti-GQ1b antibody. Ann Neurol 39:668–672PubMedCrossRef
3.
go back to reference Odaka M, Yuki N, Hirata K (2001) Anti-GQ1b antibody syndrome: clinical and immunological range. J Neurol Neurosurg Psychiatry 70:50–55PubMedCrossRef Odaka M, Yuki N, Hirata K (2001) Anti-GQ1b antibody syndrome: clinical and immunological range. J Neurol Neurosurg Psychiatry 70:50–55PubMedCrossRef
4.
go back to reference Hao Q, Saida T, Kuroki S, Nishimura M, Nukina M, Obayashi H, Saida K (1998) Antibodies to gangliosides and galactocerebroside in patients with Guilllain-Barré syndrome with preceding Campylobacter Jejuni and other identified infections. J Neuroimmunol 81:116–126PubMedCrossRef Hao Q, Saida T, Kuroki S, Nishimura M, Nukina M, Obayashi H, Saida K (1998) Antibodies to gangliosides and galactocerebroside in patients with Guilllain-Barré syndrome with preceding Campylobacter Jejuni and other identified infections. J Neuroimmunol 81:116–126PubMedCrossRef
5.
go back to reference Plomp JJ, Molenaar PC, O’Hanlon GM, Jacobs BC, Veitch J, Daha MR, van Doorn PA, van der Meché FG, Vincent A, Morgan BP, Willison HJ (1999) Miller Fisher anti-GQ1b antibodies: α-latrotoxin-like effects on motor end plates. Ann Neurol 45:189–199PubMedCrossRef Plomp JJ, Molenaar PC, O’Hanlon GM, Jacobs BC, Veitch J, Daha MR, van Doorn PA, van der Meché FG, Vincent A, Morgan BP, Willison HJ (1999) Miller Fisher anti-GQ1b antibodies: α-latrotoxin-like effects on motor end plates. Ann Neurol 45:189–199PubMedCrossRef
6.
go back to reference Radziwill AJ, Steck AJ, Borruat FX, Bogousslavsky J (1998) Isolated internal ophthalmoplegia associated with IgG anti-GQ1b antibody. Neurology 50:307PubMed Radziwill AJ, Steck AJ, Borruat FX, Bogousslavsky J (1998) Isolated internal ophthalmoplegia associated with IgG anti-GQ1b antibody. Neurology 50:307PubMed
7.
go back to reference Kikuchi M, Tagawa Y, Saotome S, Nonoyama T, Hoshino H, Yuki N (1997) Acute ophthalmoparesis is associated with IgG anti-GQ1b antibody subsequent to Streptococcus Pyogenes infection. Eur J Paediatr Neurol 1:47–48PubMedCrossRef Kikuchi M, Tagawa Y, Saotome S, Nonoyama T, Hoshino H, Yuki N (1997) Acute ophthalmoparesis is associated with IgG anti-GQ1b antibody subsequent to Streptococcus Pyogenes infection. Eur J Paediatr Neurol 1:47–48PubMedCrossRef
8.
go back to reference Lee SH, Lim GH, Kim JS, Oh SY, Kim JK, Cha JK, Yun CH, Kang JK, Lee H, Song HK, Chung KC (2008) Acute ophthalmoplegia (without ataxia) associated with anti-GQ1b antibody. Neurology 71(6):426–429PubMedCrossRef Lee SH, Lim GH, Kim JS, Oh SY, Kim JK, Cha JK, Yun CH, Kang JK, Lee H, Song HK, Chung KC (2008) Acute ophthalmoplegia (without ataxia) associated with anti-GQ1b antibody. Neurology 71(6):426–429PubMedCrossRef
9.
go back to reference Kuroki S, Saida T, Nukina M, Yoshioka M, Seino J (2001) Three patients with ophthalmoplegia associated with Campylobacter jejuni. Pediatr Neurol 25(1):71–74PubMedCrossRef Kuroki S, Saida T, Nukina M, Yoshioka M, Seino J (2001) Three patients with ophthalmoplegia associated with Campylobacter jejuni. Pediatr Neurol 25(1):71–74PubMedCrossRef
10.
go back to reference Goffette S, Sindic CJ (2000) Acute isolated ophthalmoplegia associated with high levels of anti-GQ1b antibodies. Eur Neurol 43(2):120–121PubMedCrossRef Goffette S, Sindic CJ (2000) Acute isolated ophthalmoplegia associated with high levels of anti-GQ1b antibodies. Eur Neurol 43(2):120–121PubMedCrossRef
Metadata
Title
Acute isolated ophthalmoplegia with anti-GQ1b antibodies
Authors
Andrea Rigamonti
Giuseppe Lauria
Marco Longoni
Lorenzo Stanzani
Elio Agostoni
Publication date
01-08-2011
Publisher
Springer Milan
Published in
Neurological Sciences / Issue 4/2011
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-011-0492-9

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