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01-04-2017 | Cardiac

Acute effect of static exercise in patients with aortic regurgitation assessed by cardiovascular magnetic resonance: role of left ventricular remodelling

Authors: Josep M. Alegret, Neus Martinez-Micaelo, Andre La Gerche, Luis Franco-Bonafonte, Francisco Rubio-Pérez, Nahum Calvo, Manuel Montero

Published in: European Radiology | Issue 4/2017

Abstract

Objective

In patients with aortic regurgitation (AR), the effect of static exercise (SE) on global ventricular function and AR severity has not been previously studied.

Methods

Resting and SE cardiovascular magnetic resonance (CMR) were prospectively performed in 23 asymptomatic patients with AR.

Results

During SE, we observed a decrease in regurgitant volume in both end-diastolic (EDV) and end-systolic (ESV) volume in both ventricles, as well as a slight decrease in LV ejection fraction (EF). Interestingly, responses varied depending on the degree of LV remodelling. Among patients with a greater degree of LV remodelling, we observed a decrease in LVEF (56 ± 4 % at rest vs 48 ± 7 % during SE, p = 0.001) as a result of a lower decrease in LVESV (with respect to LVEDV. Among patients with a lower degree of LV remodelling, LVEF remained unchanged. RVEF remained unchanged in both groups.

Conclusions

In patients with AR, SE provoked a reduction in preload, LV stroke volume, and regurgitant volume. In those patients with higher LV remodelling, we observed a decrease in LVEF, suggesting a lower LV contractile reserve.

Key points

• In patients with aortic regurgitation, static exercise reduced preload volume.

• In patients with aortic regurgitation, static exercise reduced stroke volume.

• In patients with aortic regurgitation, static exercise reduced regurgitant volume.

• In patients with greater remodelling, static exercise unmasked a lower contractile reserve.

• Effect of static exercise on aortic regurgitation was assessed by cardiac MR.

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Title: Acute effect of static exercise in patients with aortic regurgitation assessed by cardiovascular magnetic resonance: role of left ventricular remodelling
Authors: Josep M. Alegret
Neus Martinez-Micaelo
Andre La Gerche
Luis Franco-Bonafonte
Francisco Rubio-Pérez
Nahum Calvo
Manuel Montero
Publication date: 01-04-2017
Publisher: Springer Berlin Heidelberg
Published in: European Radiology / Issue 4/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-016-4520-2

At a glance: The STEP trials

Springer Medicine

Acute effect of static exercise in patients with aortic regurgitation assessed by cardiovascular magnetic resonance: role of left ventricular remodelling

Abstract

Objective

Methods

Results

Conclusions

Key points

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

Key points

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