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European Archives of Psychiatry and Clinical Neuroscience

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29-03-2023 | Acupuncture | Original Paper

Effects of glabellar botulinum toxin injections on resting-state functional connectivity in borderline personality disorder

Authors: Jara Schulze, Christopher Sinke, Insa Neumann, M. Axel Wollmer, Tillmann H. C. Kruger

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 1/2024

Abstract

Meta-analyses suggest a sustained alleviation of depressive symptoms through glabellar botulinum toxin (BTX) injections. This can be explained by the disruption of facial feedback loops, which may moderate and reinforce the experience of negative emotions. Borderline personality disorder (BPD) is characterized by excessive negative emotions. Here, a seed-based resting-state functional connectivity (rsFC) analysis following BTX (N = 24) or acupuncture (ACU, N = 21) treatment in BPD is presented on areas related to the motor system and emotion processing. RsFC in BPD using a seed-based approach was analyzed. MRI data were measured before and 4 weeks after treatment. Based on previous research, the rsFC focus was on limbic and motor areas as well as the salience and default mode network. Clinically, after 4 weeks both groups showed a reduction of borderline symptoms. However, the anterior cingulate cortex (ACC) and the face area in the primary motor cortex (M1) displayed aberrant rsFC after BTX compared to ACU treatment. The M1 showed higher rsFC to the ACC after BTX treatment compared to ACU treatment. In addition, the ACC displayed an increased connectivity to the M1 as well as a decrease to the right cerebellum. This study shows first evidence for BTX-specific effects in the motor face region and the ACC. The observed effects of BTX on rsFC to areas are related to motor behavior. Since symptom improvement did not differ between the two groups, a BTX-specific effect seems plausible rather than a general therapeutic effect.

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Title: Effects of glabellar botulinum toxin injections on resting-state functional connectivity in borderline personality disorder
Authors: Jara Schulze
Christopher Sinke
Insa Neumann
M. Axel Wollmer
Tillmann H. C. Kruger
Publication date: 29-03-2023
Publisher: Springer Berlin Heidelberg
Keywords: Acupuncture
Borderline Personality Disorder
Botulinum Toxin
Published in: European Archives of Psychiatry and Clinical Neuroscience / Issue 1/2024
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-023-01563-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effects of glabellar botulinum toxin injections on resting-state functional connectivity in borderline personality disorder

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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