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Open Access 01-12-2022 | Acupuncture | Study protocol

Effect of acupuncture therapy combined with fluticasone propionate in the treatment of persistent allergic rhinitis: study protocol for a randomized controlled trial

Authors: Qi Fan, Yixuan Feng, Yan Hou, Feihu Wu, Wei Zhang, Wenbin Nie, Bin Li, Zhongyu Zhou, Wenbin Fu, Lei Shi, Zhongren Sun, Hong Zhao

Published in: Trials | Issue 1/2022

Abstract

Background

Allergic rhinitis (AR) is an immunoglobulin E (IgE)-mediated inflammatory response.

Persistent allergic rhinitis (PAR) is a subtype of AR, but the treatment of PAR is still a problem. Acupuncture is used as an alternative therapy for AR in clinical practice. The aim of this study is to evaluate the effectiveness of acupuncture therapy combined with fluticasone propionate nasal spray in comparison to fluticasone propionate nasal spray alone in the relief of symptoms for PAR.

Methods

This study is a multicenter, single-blind, randomized controlled trial. A total of 260 eligible patients will be randomly assigned into the treatment group or the control group. The treatment group will receive the nasal fluticasone propionate combined with acupuncture, and the control group will receive fluticasone propionate nasal spray alone for 6 weeks. The primary outcome is the change in the Reflective Total Nasal Symptom Score (rTNSS) from baseline to the end of treatment, and the Total Non Nasal Symptom Score (TNNSS), reflective total ocular symptom score (rTOSS), Rhinitis Quality of Life Questionnaire (RQLQ), use of antiallergic drugs, and the Rhinitis Control Assessment Test (RCAT) are used as secondary outcomes. The participants will be followed up for another 24 weeks after treatment.

Discussion

This clinical trial will be able to provide high level evidence on the acupuncture therapy combined with fluticasone propionate nasal spray in the treatment of PAR.

Trial registration

ISRCTN Registry, ID: ISRCTN44040506. Registered on 22 July 2020.

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Title: Effect of acupuncture therapy combined with fluticasone propionate in the treatment of persistent allergic rhinitis: study protocol for a randomized controlled trial
Authors: Qi Fan
Yixuan Feng
Yan Hou
Feihu Wu
Wei Zhang
Wenbin Nie
Bin Li
Zhongyu Zhou
Wenbin Fu
Lei Shi
Zhongren Sun
Hong Zhao
Publication date: 01-12-2022
Publisher: BioMed Central
Keywords: Acupuncture
Allergic Rhinitis
Fluticasone
Published in: Trials / Issue 1/2022
Electronic ISSN: 1745-6215
DOI: https://doi.org/10.1186/s13063-022-06020-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effect of acupuncture therapy combined with fluticasone propionate in the treatment of persistent allergic rhinitis: study protocol for a randomized controlled trial

Abstract

Background

Methods

Discussion

Trial registration

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Discussion

Trial registration

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