Published in:
01-02-2004 | Poster presentation
Activity of the lipoxygenase inhibitor 1-phenyl-3-pyrazolidinone (phenidone) and derivatives on the expression of adhesion molecules on human umbilical vascular endothelial cells
Authors:
T Schroeder, F Neuscheler, C Karcher, H Dieterich, B Nohé
Published in:
Critical Care
|
Special Issue 1/2004
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Excerpt
Leucocyte adhesion contributes to perfusion abnormalities and tissue damage, and during trauma, shock or overwhelming inflammation. This study was performed to determine whether the lipoxygenase inhibitor phenidone and derivatives decrease the expression of adhesion molecules on stimulated endothelial cells and attenuate leucocyte–endothelial interactions under flow in vitro. …