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Pediatric Nephrology
Published in: Pediatric Nephrology 1/2018

01-01-2018 | Educational Review

Acquired cystic kidney disease: an under-recognized condition in children with end-stage renal disease

Authors: Eugene Y. H. Chan, Bradley A. Warady

Published in: Pediatric Nephrology | Issue 1/2018

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Abstract

Acquired cystic kidney disease (ACKD) is a condition that occurs predominantly in patients with end-stage renal disease (ESRD). In contrast to hereditary cystic kidney disease, ACKD is characterized by the presence of multiple small cysts in bilaterally small kidneys. Limited pediatric data suggest a high incidence (21.6–45.8%) of ACKD in children on dialysis, comparable to that in adults, with an increased frequency associated with a longer duration of dialysis. Recent research has shed light on the pathogenesis of ACKD, such as activation of proto-oncogenes. Although most patients with ACKD are asymptomatic, the condition can be complicated by renal cell carcinoma. Routine surveillance should therefore be considered in at-risk populations.
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Metadata
Title
Acquired cystic kidney disease: an under-recognized condition in children with end-stage renal disease
Authors
Eugene Y. H. Chan
Bradley A. Warady
Publication date
01-01-2018
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 1/2018
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-017-3649-9

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