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International Orthopaedics

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29-12-2023 | Acne | Original Paper

Dyslipidaemia is associated with Cutibacterium acnes hip and knee prosthetic joint infection

Authors: Alan W. Reynolds, Katherine F. Vallès, David X. Wang, Praveer Vyas, Steven Regal, Mariano Garay

Published in: International Orthopaedics | Issue 4/2024

Abstract

Purpose

Optimization of medical factors including diabetes and obesity is a cornerstone in the prevention of prosthetic joint infection (PJI). Dyslipidaemia is another component of metabolic syndrome which has not been thoroughly investigated as an individual, modifiable risk factor. This study examined the association of dyslipidaemia with PJI caused by the lipophilic microbe Cutibacterium acnes (C. acnes).

Methods

A retrospective chart review examined patients with positive C. acnes culture at hip or knee arthroplasty explantation. A control group with methicillin-sensitive Staphylococcus aureus (MSSA) positive cultures at explantation was matched for age, sex, and surgical site, as well as a second control group with no infection. A total of 80 patients were included, 16 with C. acnes, 32 with MSSA, and 32 with no infection. All patients had a lipid panel performed within one year of surgery. Lipid values and categories were compared using multinomial logistic regressions.

Results

High or borderline triglycerides (TG) (relative risk ratio (RRR) = 0.13; P = 0.013) and low high-density lipoprotein (HDL) (RRR = 0.13; P = 0.025) were significantly associated with C. acnes PJI compared to MSSA-PJI. High or borderline TG (RRR = 0.21; P = 0.041) and low HDL (RRR = 0.17; P = 0.043) were also associated with a greater probability of C. acnes infection compared to no infection.

Conclusions

The presence of elevated TG and low HDL were both associated at a statistically significant level with C. acnes hip or knee PJI compared to controls with either MSSA PJI or no infection. This may represent a specific risk factor for C. acnes PJI that is modifiable.

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Title: Dyslipidaemia is associated with Cutibacterium acnes hip and knee prosthetic joint infection
Authors: Alan W. Reynolds
Katherine F. Vallès
David X. Wang
Praveer Vyas
Steven Regal
Mariano Garay
Publication date: 29-12-2023
Publisher: Springer Berlin Heidelberg
Keywords: Acne
Joint Infection
Published in: International Orthopaedics / Issue 4/2024
Print ISSN: 0341-2695
Electronic ISSN: 1432-5195
DOI: https://doi.org/10.1007/s00264-023-06066-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Dyslipidaemia is associated with Cutibacterium acnes hip and knee prosthetic joint infection

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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