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Published in: American Journal of Clinical Dermatology 3/2024

07-03-2024 | Acne | Therapy in Practice

Management of Acne in Pregnancy

Authors: Akash Rau, Jonette Keri, Jenny E. Murase

Published in: American Journal of Clinical Dermatology | Issue 3/2024

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Abstract

Acne is one of the most common dermatological conditions to affect women of childbearing age, so it is important to consider the safety of long-term acne treatments on women who could become pregnant. In this review article, we clarify what management options are available to treat acne during pregnancy. Topical treatments, typically first-line for acne, such as azelaic acid, clindamycin, erythromycin, metronidazole, benzoyl peroxide, salicylic acid, dapsone, and retinoids, were reviewed. Systemic treatments, such as zinc supplements, cephalexin, cefadroxil, amoxicillin, azithromycin, erythromycin, and corticosteroids, typically second-line for acne, were also reviewed. Alternative treatments such as light therapy and cosmetic procedures were also evaluated. Due to recommendation of sunscreen utilization during acne treatments, sunscreen usage during pregnancy was also assessed. Management of acne during unplanned pregnancy was discussed in further detail regarding safety and adverse effects. Through summarized tables and examples of studies demonstrating safety and efficacy of treatments, the following is a resource for providers and patients to utilize for management of acne during pregnancy.
Literature
4.
go back to reference Kutlu Ö, Karadağ AS, Ünal E, Kelekçi KH, Yalçınkayaİyidal A, TopaloğluDemir F, Aksoy B, Çölgeçen E, Tosun M, Emre S, Tatlıparmak A, Demirseren DD, Kaya Özden H, Öztürk M, Özlü E, Chen W. Acne in pregnancy: a prospective multicenter, cross-sectional study of 295 patients in Turkey. Int J Dermatol. 2020;59(9):1098–105. https://doi.org/10.1111/ijd.14999.CrossRefPubMed Kutlu Ö, Karadağ AS, Ünal E, Kelekçi KH, Yalçınkayaİyidal A, TopaloğluDemir F, Aksoy B, Çölgeçen E, Tosun M, Emre S, Tatlıparmak A, Demirseren DD, Kaya Özden H, Öztürk M, Özlü E, Chen W. Acne in pregnancy: a prospective multicenter, cross-sectional study of 295 patients in Turkey. Int J Dermatol. 2020;59(9):1098–105. https://​doi.​org/​10.​1111/​ijd.​14999.CrossRefPubMed
11.
go back to reference Tuffanelli DL. Successful pregnancy in a patient with dermatitis herpetiformis treated with low-dose dapsone. Arch Dermatol. 1982;118(11):876.CrossRefPubMed Tuffanelli DL. Successful pregnancy in a patient with dermatitis herpetiformis treated with low-dose dapsone. Arch Dermatol. 1982;118(11):876.CrossRefPubMed
12.
go back to reference Kraeling ME, Bronaugh RL. In vitro percutaneous absorption of alpha hydroxy acids in human skin. J Soc Cosmet Chem. 1997;48:187–97. Kraeling ME, Bronaugh RL. In vitro percutaneous absorption of alpha hydroxy acids in human skin. J Soc Cosmet Chem. 1997;48:187–97.
14.
go back to reference Peterson H, Kircik L, Armstrong AW. Individual article: clascoterone cream 1%: mechanism of action, efficacy, and safety of a novel, first-in-class topical antiandrogen therapy for acne. J Drugs Dermatol. 2023;22(6):SF350992s7-SF350992s14.PubMed Peterson H, Kircik L, Armstrong AW. Individual article: clascoterone cream 1%: mechanism of action, efficacy, and safety of a novel, first-in-class topical antiandrogen therapy for acne. J Drugs Dermatol. 2023;22(6):SF350992s7-SF350992s14.PubMed
15.
go back to reference Panchaud A, Csajka C, Merlob P, Schaefer C, Berlin M, De Santis M, Vial T, Ieri A, Malm H, Eleftheriou G, Stahl B, Rousso P, Winterfeld U, Rothuizen LE, Buclin T. Pregnancy outcome following exposure to topical retinoids: a multicenter prospective study. J Clin Pharmacol. 2012;52(12):1844–51. https://doi.org/10.1177/0091270011429566.CrossRefPubMed Panchaud A, Csajka C, Merlob P, Schaefer C, Berlin M, De Santis M, Vial T, Ieri A, Malm H, Eleftheriou G, Stahl B, Rousso P, Winterfeld U, Rothuizen LE, Buclin T. Pregnancy outcome following exposure to topical retinoids: a multicenter prospective study. J Clin Pharmacol. 2012;52(12):1844–51. https://​doi.​org/​10.​1177/​0091270011429566​.CrossRefPubMed
20.
go back to reference Han G, Wu JJ, Del Rosso JQ. Use of topical tazarotene for the treatment of acne vulgaris in pregnancy: a literature review. J Clin Aesth Dermatol. 2020;13(9):E59–65. Han G, Wu JJ, Del Rosso JQ. Use of topical tazarotene for the treatment of acne vulgaris in pregnancy: a literature review. J Clin Aesth Dermatol. 2020;13(9):E59–65.
33.
go back to reference Piquero-Casals J, Morgado-Carrasco D, Rozas-Muñoz E, Mir-Bonafé JF, Trullàs C, Jourdan E, Piquero-Martin J, Zouboulis CC, Krutmann J. Sun exposure, a relevant exposome factor in acne patients and how photoprotection can improve outcomes. J Cosmet Dermatol. 2023;22(6):1919–28. https://doi.org/10.1111/jocd.15726. (Epub 2023 Mar 22 PMID: 36946555).CrossRefPubMed Piquero-Casals J, Morgado-Carrasco D, Rozas-Muñoz E, Mir-Bonafé JF, Trullàs C, Jourdan E, Piquero-Martin J, Zouboulis CC, Krutmann J. Sun exposure, a relevant exposome factor in acne patients and how photoprotection can improve outcomes. J Cosmet Dermatol. 2023;22(6):1919–28. https://​doi.​org/​10.​1111/​jocd.​15726. (Epub 2023 Mar 22 PMID: 36946555).CrossRefPubMed
35.
go back to reference Putra IB, Jusuf NK, Dewi NK. Skin changes and safety profile of topical products during pregnancy. J Clin Aesth Dermatol. 2022;15(2):49–57. Putra IB, Jusuf NK, Dewi NK. Skin changes and safety profile of topical products during pregnancy. J Clin Aesth Dermatol. 2022;15(2):49–57.
37.
39.
go back to reference Loureiro KD, Kao KK, Jones KL, Alvarado S, Chavez C, Dick L, Felix R, Johnson D, Chambers CD. Minor malformations characteristic of the retinoic acid embryopathy and other birth outcomes in children of women exposed to topical tretinoin during early pregnancy. Am J Med Genet A. 2005;136(2):117–21. https://doi.org/10.1002/ajmg.a.30744.CrossRefPubMed Loureiro KD, Kao KK, Jones KL, Alvarado S, Chavez C, Dick L, Felix R, Johnson D, Chambers CD. Minor malformations characteristic of the retinoic acid embryopathy and other birth outcomes in children of women exposed to topical tretinoin during early pregnancy. Am J Med Genet A. 2005;136(2):117–21. https://​doi.​org/​10.​1002/​ajmg.​a.​30744.CrossRefPubMed
41.
go back to reference Horne HW Jr, Kundsin RB. The role of mycoplasma among 81 consecutive pregnancies: a prospective study. Int J Fertil. 1980;25(4):315–7.PubMed Horne HW Jr, Kundsin RB. The role of mycoplasma among 81 consecutive pregnancies: a prospective study. Int J Fertil. 1980;25(4):315–7.PubMed
42.
go back to reference Baldwin HE. Treating acne during pregnancy and lactation. Cutis. 2015;96(1):11–2.PubMed Baldwin HE. Treating acne during pregnancy and lactation. Cutis. 2015;96(1):11–2.PubMed
Metadata
Title
Management of Acne in Pregnancy
Authors
Akash Rau
Jonette Keri
Jenny E. Murase
Publication date
07-03-2024
Publisher
Springer International Publishing
Published in
American Journal of Clinical Dermatology / Issue 3/2024
Print ISSN: 1175-0561
Electronic ISSN: 1179-1888
DOI
https://doi.org/10.1007/s40257-024-00851-6

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