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Published in: Dermatology and Therapy 5/2020

Open Access 01-10-2020 | Acne | Case Series

Subject Satisfaction with Trifarotene 50 μg/g Cream in the Treatment of Facial and Truncal Acne Vulgaris: A Case Series

Authors: Sandra M. Johnson, Rajeev Chavda, Janet C. DuBois

Published in: Dermatology and Therapy | Issue 5/2020

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Abstract

There is a paucity of literature covering patient-reported outcomes of treatments for truncal acne. Trifarotene 50 μg/g cream is a novel retinoid molecule approved for once-daily topical treatment of facial and truncal acne vulgaris. As physicians are starting to gain real-world experience with this retinoid treatment, their access to reporting from the patient’s perspective provides a valuable adjunct to the pivotal studies. We report a case series of three subjects with moderate facial and truncal acne treated with trifarotene 50 μg/g cream on the face, shoulders, upper back and upper anterior chest for 12 weeks and evaluated by satisfaction questionnaires. This case series illustrating the treatment of facial and truncal acne with trifarotene 50 μg/g cream, in the form of real-world data, describes high overall satisfaction and excellent tolerability to support the use of this new retinoid molecule in the treatment of acne vulgaris on both the face and trunk.
Literature
1.
go back to reference Claudel JP, Auffret N, Leccia MT, Poli F, Dréno B. Acne from the young patient's perspective. J Eur Acad Dermatol Venereol. 2020;34(5):942–7.CrossRefPubMed Claudel JP, Auffret N, Leccia MT, Poli F, Dréno B. Acne from the young patient's perspective. J Eur Acad Dermatol Venereol. 2020;34(5):942–7.CrossRefPubMed
2.
go back to reference Tan JK, Tang J, Fung K, et al. Prevalence and severity of facial and truncal acne in a referral cohort. J Drugs Dermatol. 2008;7(6):551–6.PubMed Tan JK, Tang J, Fung K, et al. Prevalence and severity of facial and truncal acne in a referral cohort. J Drugs Dermatol. 2008;7(6):551–6.PubMed
3.
go back to reference Del Rosso JQ, Bikowski JB, Baum E, et al. A closer look at truncal acne vulgaris: prevalence, severity, and clinical significance. J Drugs Dermatol. 2007;6(6):597–600.PubMed Del Rosso JQ, Bikowski JB, Baum E, et al. A closer look at truncal acne vulgaris: prevalence, severity, and clinical significance. J Drugs Dermatol. 2007;6(6):597–600.PubMed
6.
go back to reference Thiboutot DM, Dréno B, Abanmi A, et al. Practical management of acne for clinicians: an international consensus from the Global Alliance to Improve Outcomes in Acne. J Am Acad Dermatol. 2018;78(2 Suppl 1):S1–S23.CrossRefPubMed Thiboutot DM, Dréno B, Abanmi A, et al. Practical management of acne for clinicians: an international consensus from the Global Alliance to Improve Outcomes in Acne. J Am Acad Dermatol. 2018;78(2 Suppl 1):S1–S23.CrossRefPubMed
7.
go back to reference Kassir M, Karagaiah P, Sonthalia S, et al. Selective RAR agonists for acne vulgaris: a narrative review. J Cosmet Dermatol. 2020;19(6):1278–83.CrossRefPubMed Kassir M, Karagaiah P, Sonthalia S, et al. Selective RAR agonists for acne vulgaris: a narrative review. J Cosmet Dermatol. 2020;19(6):1278–83.CrossRefPubMed
8.
go back to reference Aubert J, Piwnica D, Bertino B, et al. Non-clinical and human pharmacology of the potent and selective topical RAR-γ agonist trifarotene. Br J Dermatol. 2018;179:442–56.PubMed Aubert J, Piwnica D, Bertino B, et al. Non-clinical and human pharmacology of the potent and selective topical RAR-γ agonist trifarotene. Br J Dermatol. 2018;179:442–56.PubMed
9.
go back to reference Thoreau E, Arlabosse J, Bouix-Peter C, et al. Structure-based design of Trifarotene (CD5789), a potent and selective RAR-γ agonist for the treatment of acne. Bioorg Med Chem Lett. 2018;28:1736–41.CrossRefPubMed Thoreau E, Arlabosse J, Bouix-Peter C, et al. Structure-based design of Trifarotene (CD5789), a potent and selective RAR-γ agonist for the treatment of acne. Bioorg Med Chem Lett. 2018;28:1736–41.CrossRefPubMed
10.
go back to reference Tan J, Thiboutot D, Popp G, et al. Randomized phase 3 evaluation of trifarotene 50 μg/g cream treatment of moderate facial and truncal acne. J Am Acad Dermatol. 2019;80(6):1691–9.CrossRefPubMed Tan J, Thiboutot D, Popp G, et al. Randomized phase 3 evaluation of trifarotene 50 μg/g cream treatment of moderate facial and truncal acne. J Am Acad Dermatol. 2019;80(6):1691–9.CrossRefPubMed
11.
go back to reference Wagner N, Benkali K, Alió Sáenz A, Poncet M, Graeber M. Clinical pharmacology and safety of trifarotene, a first-in-class RARγ-selective topical retinoid. J Clin Pharmacol. 2020;60(5):660–8.CrossRefPubMedPubMedCentral Wagner N, Benkali K, Alió Sáenz A, Poncet M, Graeber M. Clinical pharmacology and safety of trifarotene, a first-in-class RARγ-selective topical retinoid. J Clin Pharmacol. 2020;60(5):660–8.CrossRefPubMedPubMedCentral
12.
go back to reference Blume-Peytavi U, Fowler J, Kemény L, et al. Long-term safety and efficacy of trifarotene 50 μg/g cream, a first-in-class RAR-γ selective topical retinoid, in patients with moderate facial and truncal acne. J Eur Acad Dermatol Venereol. 2020;34(1):166–73.CrossRefPubMed Blume-Peytavi U, Fowler J, Kemény L, et al. Long-term safety and efficacy of trifarotene 50 μg/g cream, a first-in-class RAR-γ selective topical retinoid, in patients with moderate facial and truncal acne. J Eur Acad Dermatol Venereol. 2020;34(1):166–73.CrossRefPubMed
14.
go back to reference Myhill T, Coulson W, Nixon P, Royal S, McCormack T, Kerrouche N. Use of supplementary patient education material increases treatment adherence and satisfaction among acne patients receiving adapalene 0.1%/benzoyl peroxide 2.5% gel in primary care clinics: a multicenter, randomized controlled clinical study. Dermatol Ther (Heidelb). 2017;7(4):515–24.CrossRefPubMedPubMedCentral Myhill T, Coulson W, Nixon P, Royal S, McCormack T, Kerrouche N. Use of supplementary patient education material increases treatment adherence and satisfaction among acne patients receiving adapalene 0.1%/benzoyl peroxide 2.5% gel in primary care clinics: a multicenter, randomized controlled clinical study. Dermatol Ther (Heidelb). 2017;7(4):515–24.CrossRefPubMedPubMedCentral
Metadata
Title
Subject Satisfaction with Trifarotene 50 μg/g Cream in the Treatment of Facial and Truncal Acne Vulgaris: A Case Series
Authors
Sandra M. Johnson
Rajeev Chavda
Janet C. DuBois
Publication date
01-10-2020
Publisher
Springer Healthcare
Published in
Dermatology and Therapy / Issue 5/2020
Print ISSN: 2193-8210
Electronic ISSN: 2190-9172
DOI
https://doi.org/10.1007/s13555-020-00417-4

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