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Critical Care
Published in: Critical Care 2/2014

Open Access 01-04-2014 | Commentary

Acidosis in the critically ill - balancing risks and benefits to optimize outcome

Authors: Gerard F Curley, John G Laffey

Published in: Critical Care | Issue 2/2014

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Abstract

Acidosis is associated with poor outcome in critical illness. However, acidosis - both hypercapnic and metabolic - has direct effects that can limit tissue injury induced by many causes. There is also a clear potential for off-target harm with acute exposure (for example, raised intracranial pressure, pulmonary hypertension), and with exposure for prolonged periods (for example, increased risk of infection) or at high doses. Ongoing comprehensive determination of molecular, cellular and physiologic impact across a range of representative pathologies will allow us to understand better the risks and benefits of hypercapnia and acidosis during critical illness.
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Metadata
Title
Acidosis in the critically ill - balancing risks and benefits to optimize outcome
Authors
Gerard F Curley
John G Laffey
Publication date
01-04-2014
Publisher
BioMed Central
Published in
Critical Care / Issue 2/2014
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc13815

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