Top

Published in:

Open Access 01-12-2014 | Commentary

Acid-base status is an important factor for inflammation, but don’t forget CO₂!

Authors: Didier Payen, Houda Haloui

Published in: Critical Care | Issue 6/2014

Abstract

Zampieri and colleagues used sophisticated statistical methods to create a picture of acid-base pattern and inflammation relationship in a clinical context. The observed independent relationship between acidosis and albumin concentration and inflammatory pattern opens up a new area for research. It has become clear that, in addition to the characterization of mediators, receptors, and cellular phenotypes, the inflammatory response has to be interpreted in light of acid-base status, albumin concentration, and probably also carbon dioxide level.

Zampieri F, Kellum J, Park M, Ranzani O, Barbeiro H, de Souza H, Monteiro da Cruz Neto L, Pinheiro da Silva F: Relationship between acid-base status and inflammation in the critically ill. Crit Care 2014, 18:R154.,

Kellum JA, Song M, Li J: Science review: Extracellular acidosis and the immune response: clinical and physiologic implications. Crit Care. 2004, 8: 331-336. 10.1186/cc2900.CrossRef

Cummins EP, Selfridge AC, Sporn PH, Sznajder JI, Taylor CT: Carbon dioxide-sensing in organisms and its implications for human disease. Cell Mol Life Sci. 2014, 71: 831-845. 10.1007/s00018-013-1470-6.CrossRef

Kellum JA, Song M, Li J: Lactic and hydrochloric acids induce different patterns of inflammatory response in LPS-stimulated RAW 264.7 cells. Am J Physiol Regul Integr Comp Physiol. 2004, 286: R686-R692. 10.1152/ajpregu.00564.2003.CrossRef

Kellum JA, Song M, Venkataraman R: Effects of hyperchloremic acidosis on arterial pressure and circulating inflammatory molecules in experimental sepsis. Chest. 2004, 125: 243-248. 10.1378/chest.125.1.243.CrossRef

Bar-Or D, Thomas GW, Bar-Or R, Rael LT, Scarborough K, Rao N, Shimonkevitz R: Commercial human albumin preparations for clinical use are immunosuppressive in vitro. Crit Care Med. 2006, 34: 1707-1712. 10.1097/01.CCM.0000217923.53680.4C.CrossRef

Caironi P, Tognoni G, Masson S, Fumagalli R, Pesenti A, Romero M, Fanizza C, Caspani L, Faenza S, Grasselli G, Iapichino G, Antonelli M, Parrini V, Fiore G, Latini R, Gattinoni L: Albumin replacement in patients with severe sepsis or septic shock. N Engl J Med. 2014, 370: 1412-1421. 10.1056/NEJMoa1305727.CrossRef

Lotlikar SR, Hnatusko S, Dickenson NE, Choudhari SP, Picking WL, Patrauchan MA: Three functional beta-carbonic anhydrases in Pseudomonas aeruginosa PAO1: role in survival in ambient air. Microbiology. 2013, 159: 1748-1759. 10.1099/mic.0.066357-0.CrossRef

Title: Acid-base status is an important factor for inflammation, but don’t forget CO2!
Authors: Didier Payen
Houda Haloui
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: Critical Care / Issue 6/2014
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/s13054-014-0664-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Acid-base status is an important factor for inflammation, but don’t forget CO₂!

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 6/2014

Burns to be alive: a complication of transcutaneous cardiac stimulation

Effect of a fever control protocol-based strategy on ventilator-associated pneumonia in severely brain-injured patients

Clinical neurophysiological assessment of sepsis-associated brain dysfunction: a systematic review

Understanding skeletal muscle wasting in critically ill patients

Ventilator-associated tracheobronchitis: pre-emptive, appropriate antibiotic therapy recommended

Association of red blood cell transfusion and in-hospital mortality in patients admitted to the intensive care unit: a systematic review and meta-analysis