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Cancer & Metabolism
Literature
1.
Kamphorst JJ, Chung MK, Fan J, Rabinowitz JD: Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate. Cancer & Metabolism. 2014, 2: 23-10.1186/2049-3002-2-25.CrossRef
2.
Metallo CM, Gameiro PA, Bell EL, Mattaini KR, Yang J, Hiller K, Jewell CM, Johnson ZR, Irvine DJ, Guarente L, Kelleher JK, Vander Heiden MG, Iliopoulos O, Stephanopoulos G: Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature. 2012, 481: 380-384.
3.
Kamphorst JJ, Cross JR, Fan J, de Stanchina E, Mathew R, White EP, Thompson CB, Rabinowitz JD: Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proc Natl Acad Sci U S A. 2013, 110: 8882-8887. 10.1073/pnas.1307237110.CrossRefPubMedPubMedCentral
4.
Mullen AR, Wheaton WW, Jin ES, Chen PH, Sullivan LB, Cheng T, Yang Y, Linehan WM, Chandel NS, DeBerardinis RJ: Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature. 2012, 481: 385-388.PubMedCentral
5.
Moschen I, Broer A, Galic S, Lang F, Broer S: Significance of short chain fatty acid transport by members of the monocarboxylate transporter family (MCT). Neurochem Res. 2012, 37: 2562-2568. 10.1007/s11064-012-0857-3.CrossRefPubMed
6.
Richards RH, Dowling JA, Vreman HJ, Feldman C, Weiner MW: Acetate levels in human plasma. Proc Clin Dial Transplant Forum. 1976, 6: 73-79.PubMed
7.
Davies PG, Venkatesh B, Morgan TJ, Presneill JJ, Kruger PS, Thomas BJ, Roberts MS, Mundy J: Plasma acetate, gluconate and interleukin-6 profiles during and after cardiopulmonary bypass: a comparison of Plasma-Lyte 148 with a bicarbonate-balanced solution. Crit Care. 2011, 15: R21-10.1186/cc9966.CrossRefPubMedPubMedCentral
8.
Pomare EW, Branch WJ, Cummings JH: Carbohydrate fermentation in the human colon and its relation to acetate concentrations in venous blood. J Clin Invest. 1985, 75: 1448-1454. 10.1172/JCI111847.CrossRefPubMedPubMedCentral
9.
Tollinger CD, Vreman HJ, Weiner MW: Measurement of acetate in human blood by gas chromatography: effects of sample preparation, feeding, and various diseases. Clin Chem. 1979, 25: 1787-1790.PubMed
10.
Nuutinen H, Lindros K, Hekali P, Salaspuro M: Elevated blood acetate as indicator of fast ethanol elimination in chronic alcoholics. Alcohol. 1985, 2: 623-626. 10.1016/0741-8329(85)90090-4.CrossRefPubMed
11.
Remesy C, Demigne C, Chartier F: Origin and utilization of volatile fatty acids in the rat. Reprod Nutr Dev. 1980, 20: 1339-1349. 10.1051/rnd:19800725.CrossRefPubMed
12.
Sato H, Matsumoto M, Hanasaka S: Relations between plasma acetate, 3-hydroxybutyrate, FFA, glucose levels and energy nutrition in lactating dairy cows. J Vet Med Sci. 1999, 61: 447-451. 10.1292/jvms.61.447.CrossRefPubMed
13.
14.
15.
Korri UM, Nuutinen H, Salaspuro M: Increased blood acetate: a new laboratory marker of alcoholism and heavy drinking. Alcohol Clin Exp Res. 1985, 9: 468-471. 10.1111/j.1530-0277.1985.tb05585.x.CrossRefPubMed
16.
Lundquist F: Production and utilization of free acetate in man. Nature. 1962, 193: 579-580. 10.1038/193579b0.CrossRefPubMed
Metadata
Title
Acetate metabolism in cancer cells
Authors
Aaron M Hosios
Matthew G Vander Heiden
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Cancer & Metabolism / Issue 1/2014
Electronic ISSN: 2049-3002
DOI
https://doi.org/10.1186/s40170-014-0027-y

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