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CardioVascular and Interventional Radiology

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01-07-2016 | Case Report

Abscopal Effects and Yttrium-90 Radioembolization

Authors: Anish Ghodadra, Sumantha Bhatt, Juan C. Camacho, Hyun S. Kim

Published in: CardioVascular and Interventional Radiology | Issue 7/2016

Abstract

We present the case of an 80-year-old male with squamous cell carcinoma with bilobar hepatic metastases who underwent targeted Yttrium-90 radioembolization of the right hepatic lobe lesion. Subsequently, there was complete regression of the nontargeted, left hepatic lobe lesion. This may represent the first ever reported abscopal effect in radioembolization. The abscopal effect refers to the phenomenon of tumor response in nontargeted sites after targeted radiotherapy. In this article, we briefly review the immune-mediated mechanisms responsible for the abscopal effect.

Reynders K, Illidge T, Siva S, Chang JY, De Ruysscher D. The abscopal effect of local radiotherapy: using immunotherapy to make a rare event clinically relevant. Cancer Treat Rev. 2015;. doi:10.1016/j.ctrv.2015.03.011.PubMed

Siva S, MacManus MP, Martin RF, Martin OA. Abscopal effects of radiation therapy: a clinical review for the radiobiologist. Cancer Lett. 2015;356:82–90.CrossRefPubMed

Waitz R, Solomon SB. Can local radiofrequency ablation of tumors generate systemic immunity against metastatic disease? Radiology. 2009;251:1–2.CrossRefPubMed

Yu Z, et al. Treatment of osteosarcoma with microwave thermal ablation to induce immunogenic cell death. Oncotarget. 2014;5:6526–39.CrossRefPubMedPubMedCentral

Reits EA, et al. Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy. J Exp Med. 2006;203:1259–71.CrossRefPubMedPubMedCentral

Frey B, et al. Induction of Abscopal Anti-Tumor Immunity and Immunogenic Tumor Cell Death by Ionizing Irradiation - Implications for Cancer Therapies. Curr Med Chem. 2012;19:1751–64.CrossRefPubMed

Tesniere A, et al. Molecular characteristics of immunogenic cancer cell death. Cell Death Differ. 2007;15:3–12.CrossRefPubMed

Chiriva-Internati M, et al. Gamma-radiation upregulates MHC class I/II and ICAM-I molecules in multiple myeloma cell lines and primary tumors. In Vitro Cell Dev Biol Anim. 2006;42:89–95.CrossRefPubMed

Chakraborty M, et al. Irradiation of tumor cells up-regulates Fas and enhances CTL lytic activity and CTL adoptive immunotherapy. J Immunol Baltim Md. 2003;1950(170):6338–47.

10.

Hadrup S, Donia M, thor Straten P. Effector CD4 and CD8 T cells and their role in the tumor microenvironment. Cancer Microenviron. 2012;6:123–33.CrossRefPubMedPubMedCentral

11.

Gajewski TF, et al. Immune resistance orchestrated by the tumor microenvironment. Immunol Rev. 2006;213:131–45.CrossRefPubMed

12.

Gupta A, et al. Radiotherapy promotes tumor-specific effector CD8⁺ T cells via dendritic cell activation. J Immunol Baltim Md. 2012;1950(189):558–66.

13.

Demaria S, et al. Ionizing radiation inhibition of distant untreated tumors (abscopal effect) is immune mediated. Int J Radiat Oncol Biol Phys. 2004;58:862–70.CrossRefPubMed

14.

Teitz-Tennenbaum S, et al. Radiotherapy potentiates the therapeutic efficacy of intratumoral dendritic cell administration. Cancer Res. 2003;63:8466–75.PubMed

15.

Shiraishi K, et al. Enhancement of antitumor radiation efficacy and consistent induction of the abscopal effect in mice by ECI301, an active variant of macrophage inflammatory protein-1alpha. Clin Cancer Res Off J Am Assoc Cancer Res. 2008;14:1159–66.CrossRef

16.

Zhao W, et al. Hepatic stellate cells promote tumor progression by enhancement of immunosuppressive cells in an orthotopic liver tumor mouse model. Lab Invest. 2014;94:182–91.CrossRefPubMed

17.

Formenti SC, Demaria S. Combining Radiotherapy and Cancer Immunotherapy: a paradigm shift. J Natl Cancer Inst. 2013;105:256–65.CrossRefPubMedPubMedCentral

18.

Chandra RA, et al. A systematic evaluation of abscopal responses following radiotherapy in patients with metastatic melanoma treated with ipilimumab. OncoImmunology. 2015;0:00–00.

19.

Barker CA, Postow MA. Combinations of radiation therapy and immunotherapy for melanoma: a review of clinical outcomes. Int J Radiat Oncol Biol Phys. 2014;88:986–97.CrossRefPubMedPubMedCentral

20.

Camphausen K, et al. Radiation abscopal antitumor effect is mediated through p53. Cancer Res. 2003;63:1990–3.PubMed

21.

Filatenkov A, et al. Ablative tumor radiation can change the tumor immune cell microenvironment to induce durable complete remissions. Clin Cancer Res. 2015;. doi:10.1158/1078-0432.CCR-14-2824.PubMed

22.

Kennedy AS, Nutting C, Coldwell D, Gaiser J, Drachenberg C. Pathologic response and microdosimetry of 90Y microspheres in man: review of four explanted whole livers. Int J Radiat Oncol. 2004;60:1552–63.CrossRef

Title: Abscopal Effects and Yttrium-90 Radioembolization
Authors: Anish Ghodadra
Sumantha Bhatt
Juan C. Camacho
Hyun S. Kim
Publication date: 01-07-2016
Publisher: Springer US
Published in: CardioVascular and Interventional Radiology / Issue 7/2016
Print ISSN: 0174-1551
Electronic ISSN: 1432-086X
DOI: https://doi.org/10.1007/s00270-015-1259-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abscopal Effects and Yttrium-90 Radioembolization

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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