Skip to main content
Top
Published in: BMC Anesthesiology 1/2018

Open Access 01-12-2018 | Case report

Abnormally low Bispectral index and severe hypoglycemia during maintenance of and recovery from general anesthesia in diabetic retinopathy surgery: two case reports

Authors: Chunhua Xi, Chuxiong Pan, Tianzuo Li

Published in: BMC Anesthesiology | Issue 1/2018

Login to get access

Abstract

Background

Hypoglycemia is one of the most fatal complications during the perioperative period. General anesthesia or sedation can mask a hypoglycemia-altered mental status. Acute hypoglycemia might result in permanent brain injury. There is no way to detect hypoglycemia during general anesthesia, except for intermittent blood glucose monitoring.

Case presentation

Hypoglycemia is associated with changes in electroencephalogram readings. Here, we report two cases of patients with an abnormally low Bispectral Index (BIS) associated with diabetic retinopathy surgery, one in the recovery stage of general anesthesia and the other in the maintenance of general anesthesia. Hemodynamics were stable. Severe hypoglycemia (1.6 mmol/L and 2.2 mmol/L) was then detected. BIS increased with the correction of severe hypoglycemia.

Conclusions

For diabetic patients, when the intraoperative BIS value is abnormally low, hypoglycemia should be considered. Severe hypoglycemia may be presented in BIS monitoring during general anesthesia.
Literature
1.
go back to reference Rajendran R, Rayman G. Serious harm from inpatient hypoglycaemia: a survey of hospitals in the UK. Diabet Med. 2014;31(10):1218–21.CrossRefPubMed Rajendran R, Rayman G. Serious harm from inpatient hypoglycaemia: a survey of hospitals in the UK. Diabet Med. 2014;31(10):1218–21.CrossRefPubMed
2.
go back to reference Shaefer C, Hinnen D, Sadler C. Hypoglycemia and diabetes: increased need for awareness. Curr Med Res Opin. 2016;32(9):1479–86.CrossRefPubMed Shaefer C, Hinnen D, Sadler C. Hypoglycemia and diabetes: increased need for awareness. Curr Med Res Opin. 2016;32(9):1479–86.CrossRefPubMed
3.
go back to reference Engoren M, Schwann TA, Habib RH. Hyperglycemia, hypoglycemia, and glycemic complexity are associated with worse outcomes after surgery. J Crit Care. 2014;29(4):611–7.CrossRefPubMed Engoren M, Schwann TA, Habib RH. Hyperglycemia, hypoglycemia, and glycemic complexity are associated with worse outcomes after surgery. J Crit Care. 2014;29(4):611–7.CrossRefPubMed
4.
go back to reference Goh SN, Yeoh E, Tan KY. Impact of perioperative hypoglycaemia in subjects with diabetes undergoing colorectal surgery. Int J Color Dis. 2017;32(2):209–14.CrossRef Goh SN, Yeoh E, Tan KY. Impact of perioperative hypoglycaemia in subjects with diabetes undergoing colorectal surgery. Int J Color Dis. 2017;32(2):209–14.CrossRef
5.
go back to reference Workgroup on Hypoglycemia, American Diabetes Association. Defining and reporting hypoglycemia in diabetes: a report from the American Diabetes Association Workgroup on Hypoglycemia. Diabetes Care. 2005;28(5):1245–9. Workgroup on Hypoglycemia, American Diabetes Association. Defining and reporting hypoglycemia in diabetes: a report from the American Diabetes Association Workgroup on Hypoglycemia. Diabetes Care. 2005;28(5):1245–9.
6.
go back to reference Desouza C, Salazar H, Cheong B, Murgo J, Fonseca V. Association of hypoglycemia and cardiac ischemia: a study based on continuous monitoring. Diabetes Care. 2003;26(5):1485–9.CrossRefPubMed Desouza C, Salazar H, Cheong B, Murgo J, Fonseca V. Association of hypoglycemia and cardiac ischemia: a study based on continuous monitoring. Diabetes Care. 2003;26(5):1485–9.CrossRefPubMed
7.
go back to reference Reno CM, Daphna-Iken D, Chen YS, VanderWeele J, Jethi K, Fisher SJ. Severe hypoglycemia-induced lethal cardiac arrhythmias are mediated by sympathoadrenal activation. Diabetes. 2013;62(10):3570–81.CrossRefPubMedPubMedCentral Reno CM, Daphna-Iken D, Chen YS, VanderWeele J, Jethi K, Fisher SJ. Severe hypoglycemia-induced lethal cardiac arrhythmias are mediated by sympathoadrenal activation. Diabetes. 2013;62(10):3570–81.CrossRefPubMedPubMedCentral
8.
go back to reference Languren G, Montiel T, Julio-Amilpas A, Massieu L. Neuronal damage and cognitive impairment associated with hypoglycemia: an integrated view. Neurochem Int. 2013;63(4):331–43.CrossRefPubMed Languren G, Montiel T, Julio-Amilpas A, Massieu L. Neuronal damage and cognitive impairment associated with hypoglycemia: an integrated view. Neurochem Int. 2013;63(4):331–43.CrossRefPubMed
10.
go back to reference Xie XW, Xu L, Jonas JB, Wang YX. Prevalence of diabetic retinopathy among subjects with known diabetes in China: the Beijing eye study. Eur J Ophthalmol. 2009;19(1):91–9.CrossRefPubMed Xie XW, Xu L, Jonas JB, Wang YX. Prevalence of diabetic retinopathy among subjects with known diabetes in China: the Beijing eye study. Eur J Ophthalmol. 2009;19(1):91–9.CrossRefPubMed
11.
go back to reference Auer RN, Olsson Y, Siesjo BK. Hypoglycemic brain injury in the rat. Correlation of density of brain damage with the EEG isoelectric time: a quantitative study. Diabetes. 1984;33(11):1090–8.CrossRefPubMed Auer RN, Olsson Y, Siesjo BK. Hypoglycemic brain injury in the rat. Correlation of density of brain damage with the EEG isoelectric time: a quantitative study. Diabetes. 1984;33(11):1090–8.CrossRefPubMed
13.
go back to reference Kalra S, Bajwa SJ, Baruah M, Sehgal V. Hypoglycaemia in anesthesiology practice: diagnostic, preventive, and management strategies. Saudi J Anaesth. 2013;7(4):447–52.CrossRefPubMedPubMedCentral Kalra S, Bajwa SJ, Baruah M, Sehgal V. Hypoglycaemia in anesthesiology practice: diagnostic, preventive, and management strategies. Saudi J Anaesth. 2013;7(4):447–52.CrossRefPubMedPubMedCentral
14.
go back to reference Tribl G, Howorka K, Heger G, Anderer P, Thoma H, Zeitlhofer J. EEG topography during insulin-induced hypoglycemia in patients with insulin-dependent diabetes mellitus. Eur Neurol. 1996;36(5):303–9.CrossRefPubMed Tribl G, Howorka K, Heger G, Anderer P, Thoma H, Zeitlhofer J. EEG topography during insulin-induced hypoglycemia in patients with insulin-dependent diabetes mellitus. Eur Neurol. 1996;36(5):303–9.CrossRefPubMed
16.
go back to reference Hansen GL, Foli-Andersen P, Fredheim S, Juhl C, Remvig LS, Rose MH, Rosenzweig I, Beniczky S, Olsen B, Pilgaard K, et al. Hypoglycemia-associated EEG changes in Prepubertal children with type 1 diabetes. J Diabetes Sci Technol. 2016;10(6):1222–9.CrossRefPubMedPubMedCentral Hansen GL, Foli-Andersen P, Fredheim S, Juhl C, Remvig LS, Rose MH, Rosenzweig I, Beniczky S, Olsen B, Pilgaard K, et al. Hypoglycemia-associated EEG changes in Prepubertal children with type 1 diabetes. J Diabetes Sci Technol. 2016;10(6):1222–9.CrossRefPubMedPubMedCentral
17.
go back to reference Constant I, Sabourdin N. The EEG signal: a window on the cortical brain activity. Paediatr Anaesth. 2012;22(6):539–52.CrossRefPubMed Constant I, Sabourdin N. The EEG signal: a window on the cortical brain activity. Paediatr Anaesth. 2012;22(6):539–52.CrossRefPubMed
18.
go back to reference Narayanaswamy M. Decrease in Bispectral index while correcting hyperglycemia and an increase in Bispectral index with correction of hypoglycemia. Anesth Analg. 2009;109(3):995.CrossRefPubMed Narayanaswamy M. Decrease in Bispectral index while correcting hyperglycemia and an increase in Bispectral index with correction of hypoglycemia. Anesth Analg. 2009;109(3):995.CrossRefPubMed
Metadata
Title
Abnormally low Bispectral index and severe hypoglycemia during maintenance of and recovery from general anesthesia in diabetic retinopathy surgery: two case reports
Authors
Chunhua Xi
Chuxiong Pan
Tianzuo Li
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Anesthesiology / Issue 1/2018
Electronic ISSN: 1471-2253
DOI
https://doi.org/10.1186/s12871-018-0510-z

Other articles of this Issue 1/2018

BMC Anesthesiology 1/2018 Go to the issue