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World Journal of Surgery

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01-04-2015 | Original Scientific Report

Aberrant Loss of Dickkopf-3 in Gastric Cancer: Can It Predict Lymph Node Metastasis Preoperatively?

Authors: Joong-Min Park, Mi Kyung Kim, Kyong-Choun Chi, Jae Hyung Kim, Sang-Hoon Lee, Eun-Ju Lee

Published in: World Journal of Surgery | Issue 4/2015

Abstract

Background

Dickkopf-3 (DKK3) may act as a tumor suppressor as it is down-regulated in various types of cancer. This study assessed the DKK3 protein expression in gastric cancer and its potential value as a prognostic marker.

Methods

DKK3 expression was evaluated by immunohistochemistry in 158 gastric cancer samples from patients who underwent gastrectomy from 2002 to 2008. Clinicopathological parameters and survival data were analyzed.

Results

Loss of DKK3 expression was found in 64 of 158 (40.5 %) samples, and it was associated with advanced T stage (p < 0.001), lymph node metastasis (p < 0.001), UICC TNM stage (p < 0.001), tumor location (p = 0.029), lymphovascular invasion (p = 0.035), and perineural invasion (p = 0.032). Patients without DKK3 expression in tumor cells had a significantly worse disease-free and overall survival than those with DKK3 expression (p < 0.001, and p = 0.001, respectively). TNM stage (p = 0.028 and p < 0.001, respectively) and residual tumor (p < 0.001 and p = 0.003, respectively) were independent predictors of disease-free and overall survival. Based on the preoperative clinical stage assessed by computed tomography (CT), loss of DKK3 expression was predominantly associated with worse prognosis in patients with clinically node-negative advanced gastric cancer (AGC). The combination of DKK3 expression status and CT increased the accuracy of CT staging for predicting lymph node involvement from 71.5 to 80.0 % in AGC patients.

Conclusion

Loss of DKK3 protein expression was significantly associated with poor survival in patients with gastric cancer and was strongly correlated with the TNM stage. DKK3 might be a potential biomarker of lymph node involvement that can improve the predictive power of CT.

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Title: Aberrant Loss of Dickkopf-3 in Gastric Cancer: Can It Predict Lymph Node Metastasis Preoperatively?
Authors: Joong-Min Park
Mi Kyung Kim
Kyong-Choun Chi
Jae Hyung Kim
Sang-Hoon Lee
Eun-Ju Lee
Publication date: 01-04-2015
Publisher: Springer US
Published in: World Journal of Surgery / Issue 4/2015
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-014-2886-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Aberrant Loss of Dickkopf-3 in Gastric Cancer: Can It Predict Lymph Node Metastasis Preoperatively?

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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