A successful treatment with 5 methyltetrahydrofolate of a 677 TT MTHFR woman suffering premature ovarian insufficiency post a NHL (non-Hodgkin’s lymphoma) and RPL (repeat pregnancy losses)

Excerpt

Methylation is an ubiquitous regulatory biochemical process in cellular physiology. It is involved in immune response, neurotransmitter function, trans-membrane transport and DNA repair. But it also plays a mandatory role in gene expression regulation and silencing via imprinting and epigenesis, two processes totally dependent upon methylation of DNA and histones. These two last biochemical regulations are of major importance in gametogenesis and early embryo development. The folate cycle is a major partner in methylation: it allows the regeneration of methionine from homocysteine post methylation via SAM (S Adenosyl Methionine) the ubiquitous co factor of Methylation (see fig.1). MTHFR is a strong effector of the folate cycle, but its genetic variants, 677CT and 1298AC, exert a reduced enzymatic activity. Besides being implicated in circulatory and cardiac problems and cancer, these variants exert a strong correlation with the impairment of reproductive functions including male gametogenesis [1], early and late embryogenesis [2, 3], trophoblast development and implantation [4, 5] and may be involved in recurrent pregnancy losses (RPLs) [6, 7]. Non-Hodgkin lymphoma (NHL) is also strongly correlated with these SNPs [8] High doses of folic acid are not an answer for these problems: the synthetic folic acid (Pteroyl Glutamic acid) has a poor capacity to enter the folate cycle to form Tetrahyydrofolate (THF) [9] and then 5 MTHF the active compound necessary for the recycling of Hcy (see fig.1). This leads the occurrence in circulation of UMFA, unmetabolized folic acid syndrome, which may have very negative effects including a flair up of some tumors (Colorectal, prostate). This report reviews the case of a female patient who had RPLs and premature ovarian insufficiency following treatment for NHL. After discovering the homozygous mutation for MTHFR T677 T, the patient was treated successfully with 5 MTHF and delivered a healthy male baby.

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