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01-11-2016 | Genetic Disorders (W Berrettini, Section Editor)

A Slice of the Suicidal Brain: What Have Postmortem Molecular Studies Taught Us?

Authors: Daniel Almeida, Gustavo Turecki

Published in: Current Psychiatry Reports | Issue 11/2016

Abstract

Suicide ranks amongst the leading causes of death worldwide. Contemporary models of suicide risk posit that suicide results from the interaction of distal and proximal factors, including neurobiological, psychological/clinical, and social factors. While a wealth of neurobiological studies aimed at identifying biological processes associated with suicidal behaviour have been conducted over the last decades, the more recent development of arrays and high-throughput sequencing methods have led to an increased capacity and interest in the study of genomic factors. Postmortem studies are a unique tool to directly investigate genomic processes that may be dysregulated in the suicidal brain. In this review, we discuss postmortem literature investigating functional genomic studies of suicide, particularly focusing on epigenetic mechanisms.

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Title: A Slice of the Suicidal Brain: What Have Postmortem Molecular Studies Taught Us?
Authors: Daniel Almeida
Gustavo Turecki
Publication date: 01-11-2016
Publisher: Springer US
Published in: Current Psychiatry Reports / Issue 11/2016
Print ISSN: 1523-3812
Electronic ISSN: 1535-1645
DOI: https://doi.org/10.1007/s11920-016-0736-8

Keynote webinar | Spotlight on medication adherence

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A Slice of the Suicidal Brain: What Have Postmortem Molecular Studies Taught Us?

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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Other articles of this Issue 11/2016

Anxiety Disorders and Cardiovascular Disease

The Role of Fear-Related Behaviors in the 2013–2016 West Africa Ebola Virus Disease Outbreak

Psychological Mechanisms of PTSD and Its Treatment

Identifying and Managing Malingering and Factitious Disorder in the Military

Apathy in Dementia: Systematic Review of Recent Evidence on Pharmacological Treatments

Cognitive, Emotional, Temperament, and Personality Trait Correlates of Suicidal Behavior