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01-01-2012 | Short Communication

A simple quantitation method for benzoylecgonine from oral fluid, blood, and urine samples used for determining 22 illicit and licit drugs by GC–MS with liquid–liquid extraction

Authors: László Institóris, Vilmos Angyal, Zsófia Árok, Éva Kereszty, Tibor Varga

Published in: Forensic Toxicology | Issue 1/2012

Abstract

The analytical system used for determination of 22 illicit and licit drugs by gas chromatography–mass spectrometry following liquid–liquid extraction has been extended with an additional extraction step with n-butyl acetate:CH₂Cl₂ = 1:8 to determine benzoylecgonine from the same oral fluid, blood, or urine samples. The extraction recovery of benzoylecgonine was 39.7% for oral fluid, 14.9% for blood, and 26.7% for urine; the cutoffs were 25, 8.0, and 8.0 ng/ml, respectively. The method was fully validated and proved suitable in further proficiency tests and for analysis of 2738 oral fluid, 197 blood, and 1298 urine samples.

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Title: A simple quantitation method for benzoylecgonine from oral fluid, blood, and urine samples used for determining 22 illicit and licit drugs by GC–MS with liquid–liquid extraction
Authors: László Institóris
Vilmos Angyal
Zsófia Árok
Éva Kereszty
Tibor Varga
Publication date: 01-01-2012
Publisher: Springer Japan
Published in: Forensic Toxicology / Issue 1/2012
Print ISSN: 1860-8965
Electronic ISSN: 1860-8973
DOI: https://doi.org/10.1007/s11419-011-0128-z

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Springer Medicine

A simple quantitation method for benzoylecgonine from oral fluid, blood, and urine samples used for determining 22 illicit and licit drugs by GC–MS with liquid–liquid extraction

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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