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BMC Medical Genetics
Published in: BMC Medical Genetics 1/2006

Open Access 01-12-2006 | Research article

A role for CETP TaqIB polymorphism in determining susceptibility to atrial fibrillation: a nested case control study

Authors: Folkert W Asselbergs, Jason H Moore, Maarten P van den Berg, Eric B Rimm, Rudolf A de Boer, Robin P Dullaart, Gerjan Navis, Wiek H van Gilst

Published in: BMC Medical Genetics | Issue 1/2006

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Abstract

Background

Studies investigating the genetic and environmental characteristics of atrial fibrillation (AF) may provide new insights in the complex development of AF. We aimed to investigate the association between several environmental factors and loci of candidate genes, which might be related to the presence of AF.

Methods

A nested case-control study within the PREVEND cohort was conducted. Standard 12 lead electrocardiograms were recorded and AF was defined according to Minnesota codes. For every case, an age and gender matched control was selected from the same population (n = 194). In addition to logistic regression analyses, the multifactor-dimensionality reduction (MDR) method and interaction entropy graphs were used for the evaluation of gene-gene and gene-environment interactions. Polymorphisms in genes from the Renin-angiotensin, Bradykinin and CETP systems were included.

Results

Subjects with AF had a higher prevalence of electrocardiographic left ventricular hypertrophy, ischemic heart disease, hypertension, renal dysfunction, elevated levels of C-reactive protein (CRP) and increased urinary albumin excretion as compared to controls. The polymorphisms of the Renin-angiotensin system and Bradykinin gene did not show a significant association with AF (p > 0.05). The TaqIB polymorphism of the CETP gene was significantly associated with the presence of AF (p < 0.05). Using the MDR method, the best genotype-phenotype models included the combination of micro- or macroalbuminuria and CETP TaqIB polymorphism, CRP >3 mg/L and CETP TaqIB polymorphism, renal dysfunction and the CETP TaqIB polymorphism, and ischemic heart disease and CETP TaqIB polymorphism (1000 fold permutation testing, P < 0.05). Interaction entropy graph showed that the combination of albuminuria and CETP TaqIB polymorphism removed the most entropy.

Conclusion

CETP TaqIB polymorphism is significantly associated with the presence of AF in the context of micro- or macroalbuminuria, elevated C-reactive protein, renal dysfunction, and ischemic heart disease.
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Metadata
Title
A role for CETP TaqIB polymorphism in determining susceptibility to atrial fibrillation: a nested case control study
Authors
Folkert W Asselbergs
Jason H Moore
Maarten P van den Berg
Eric B Rimm
Rudolf A de Boer
Robin P Dullaart
Gerjan Navis
Wiek H van Gilst
Publication date
01-12-2006
Publisher
BioMed Central
Published in
BMC Medical Genetics / Issue 1/2006
Electronic ISSN: 1471-2350
DOI
https://doi.org/10.1186/1471-2350-7-39

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