Skip to main content
Top
Published in: HAND 2/2015

01-06-2015

A retrospective comparison of the management of recalcitrant lateral elbow tendinosis: platelet-rich plasma injections versus surgery

Authors: Ronald D. Ford, William P. Schmitt, Kyle Lineberry, Paul Luce

Published in: HAND | Issue 2/2015

Login to get access

Abstract

Background

The aim of this study is to compare the outcomes of platelet-rich plasma (PRP) injections to surgical release and decortication for lateral elbow tendinosis within a similar patient population.

Methods

A retrospective chart review was performed on two groups of patients, receiving either PRP injections (n = 28) or surgery (n = 50). Patient demographics, clinical presentation, pain score, worker’s compensation status, and previous steroid injections were recorded. Primary outcomes included pain and symptom improvement, range of motion, return to work, and postoperative complications.

Results

Demographics, duration of symptoms, and exam findings were similar between the PRP and surgical patients. There was no significant difference in pain and symptom improvement. Pain improvement was reported in 89.3 % of PRP patients and 84 % of surgical patients, with a reported percent reduction in pain of 61.1 and 55 %, respectively. Symptoms other than pain improved in 85.7 and 88 % of the PRP and surgical patients, respectively. Tenderness to palpation at the lateral epicondyle (64.3 % PRP, 44 % surgical), pain with resisted wrist extension (35.7 % PRP, 30 % surgical), or residual symptoms other than pain (14.3 % PRP, 10 % surgical) were not significantly different between groups at last follow-up. Eighty-two percent of patients in both the PRP and surgical groups returned to work. No complications were reported. Mean follow-up was 315 vs. 352 days for the PRP and surgical groups, respectively.

Conclusions

Similar outcomes in pain improvement and return to work may be achievable with either PRP injections or surgery in recalcitrant lateral elbow tendinosis. PRP injections may be a reasonable alternative for patients apprehensive to proceed with surgery or poor surgical candidates.
Literature
1.
go back to reference Johnson GW, Cadwallader K, Scheffel SB, Epperly TD. Treatment of lateral epicondylitis. Am Fam Physician. 2007;76(6):843–8.PubMed Johnson GW, Cadwallader K, Scheffel SB, Epperly TD. Treatment of lateral epicondylitis. Am Fam Physician. 2007;76(6):843–8.PubMed
2.
go back to reference Nirschl RP, Pettrone FA. The surgical treatment of lateral epicondylitis. J Bone Joint Surg Am. 1979;61(6A):832–9.PubMed Nirschl RP, Pettrone FA. The surgical treatment of lateral epicondylitis. J Bone Joint Surg Am. 1979;61(6A):832–9.PubMed
3.
go back to reference Scher DL, Wolf JM, Owens BD. Lateral epicondylitis. Orthopedics. 2009;32(4):276–82.CrossRef Scher DL, Wolf JM, Owens BD. Lateral epicondylitis. Orthopedics. 2009;32(4):276–82.CrossRef
4.
go back to reference Struijs PA, Kerkhoffs GM, Assendelft WJ, et al. Conservative treatment of lateral epicondylitis: brace versus physical therapy or a combination of both—a randomized clinical trial. Am J Sports Med. 2004;32(2):462–9.CrossRefPubMed Struijs PA, Kerkhoffs GM, Assendelft WJ, et al. Conservative treatment of lateral epicondylitis: brace versus physical therapy or a combination of both—a randomized clinical trial. Am J Sports Med. 2004;32(2):462–9.CrossRefPubMed
5.
go back to reference Smidt N, van der Windt DA, Assendelft WJ, et al. Corticosteroid injections, physiotherapy, or a wait-and-see policy for lateral epicondylitis: a randomized controlled trial. Lancet. 2002;359(37):657–62.CrossRefPubMed Smidt N, van der Windt DA, Assendelft WJ, et al. Corticosteroid injections, physiotherapy, or a wait-and-see policy for lateral epicondylitis: a randomized controlled trial. Lancet. 2002;359(37):657–62.CrossRefPubMed
6.
go back to reference Budoff JE. Tendinopathies of the hand, wrist, and elbow. In: Trumble TE, Rayan GM, Budoff JE, Baratz ME, editors. Principles of hand surgery and therapy. Saunders/Elsevier: Philadelphia; 2010. p. 337–51. Budoff JE. Tendinopathies of the hand, wrist, and elbow. In: Trumble TE, Rayan GM, Budoff JE, Baratz ME, editors. Principles of hand surgery and therapy. Saunders/Elsevier: Philadelphia; 2010. p. 337–51.
7.
go back to reference Solveborn A, Buch F, Mjallmin H, Adalberth G. Cortisone injection with anesthetic additive for radial epicondylagia (tennis elbow). Clin Orthop Relat Res.1995;316:99–105 Solveborn A, Buch F, Mjallmin H, Adalberth G. Cortisone injection with anesthetic additive for radial epicondylagia (tennis elbow). Clin Orthop Relat Res.1995;316:99–105
8.
go back to reference Newcomer KL, Laskowski ER, Idank DM, McLean TJ, Egan KS. Corticosteroid injection in early treatment of lateral epicondylitis. Clin J Sport Med. 2001;11:214–22.CrossRefPubMed Newcomer KL, Laskowski ER, Idank DM, McLean TJ, Egan KS. Corticosteroid injection in early treatment of lateral epicondylitis. Clin J Sport Med. 2001;11:214–22.CrossRefPubMed
9.
go back to reference Coombes BK, Bisset L, Brooks P, Khan A, Vicenzino B. Effect of corticosteroid injection, physiotherapy, or both on clinical outcomes in patients with unilateral lateral epicondylalgia: a randomized controlled trial. JAMA. 2013;309(5):461–9.CrossRefPubMed Coombes BK, Bisset L, Brooks P, Khan A, Vicenzino B. Effect of corticosteroid injection, physiotherapy, or both on clinical outcomes in patients with unilateral lateral epicondylalgia: a randomized controlled trial. JAMA. 2013;309(5):461–9.CrossRefPubMed
10.
go back to reference Buchbinder R, Green SE, Youd JM. Systematic review of the efficacy and safety of shock wave therapy for lateral elbow pain. J Rheumatol. 2006;33(7):1351–63.PubMed Buchbinder R, Green SE, Youd JM. Systematic review of the efficacy and safety of shock wave therapy for lateral elbow pain. J Rheumatol. 2006;33(7):1351–63.PubMed
11.
go back to reference Mishra A, Pavelko T. Treatment of chronic elbow tendinosis with buffered platelet-rich plasma. Am J Sports Med. 2006;10(10):1–5. Mishra A, Pavelko T. Treatment of chronic elbow tendinosis with buffered platelet-rich plasma. Am J Sports Med. 2006;10(10):1–5.
12.
go back to reference Peerbooms JC, Sluimer J, Bruijn DJ, Gosens T. Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial: platelet-rich plasma versus corticosteroid injection with a 1-year follow-up. Am J Sports Med. 2010;38(2):255–62.CrossRefPubMed Peerbooms JC, Sluimer J, Bruijn DJ, Gosens T. Positive effect of an autologous platelet concentrate in lateral epicondylitis in a double-blind randomized controlled trial: platelet-rich plasma versus corticosteroid injection with a 1-year follow-up. Am J Sports Med. 2010;38(2):255–62.CrossRefPubMed
13.
go back to reference Gosens T, Peerbooms JC, van Laar W, et al. Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis. Am J Sports Med. 2011;39(6):1200–8.CrossRefPubMed Gosens T, Peerbooms JC, van Laar W, et al. Ongoing positive effect of platelet-rich plasma versus corticosteroid injection in lateral epicondylitis. Am J Sports Med. 2011;39(6):1200–8.CrossRefPubMed
14.
go back to reference Krogh TP, Bartels EM, Ellingsen T, et al. Comparative effectiveness of injection therapies in lateral epicondylitis: a systematic review and network meta-analysis of randomized controlled trials. Am J Sports Med. 2013;41(6):1435–46.CrossRefPubMed Krogh TP, Bartels EM, Ellingsen T, et al. Comparative effectiveness of injection therapies in lateral epicondylitis: a systematic review and network meta-analysis of randomized controlled trials. Am J Sports Med. 2013;41(6):1435–46.CrossRefPubMed
15.
go back to reference Monto RR. Platelet-rich plasma efficacy versus corticosteroid injection treatment for chronic severe plantar fasciitis. Foot Ankle Int. 2014;35(4):313–8.CrossRefPubMed Monto RR. Platelet-rich plasma efficacy versus corticosteroid injection treatment for chronic severe plantar fasciitis. Foot Ankle Int. 2014;35(4):313–8.CrossRefPubMed
16.
go back to reference Krogh TP, Fredberg U, Stengaard-Pedersen K, et al. Treatment of lateral epicondylitis with platelet-rich plasma, glucocorticoid, or saline: a randomized, double-blind, placebo-controlled trial. Am J Sports Med. 2013;41:625–35.CrossRefPubMed Krogh TP, Fredberg U, Stengaard-Pedersen K, et al. Treatment of lateral epicondylitis with platelet-rich plasma, glucocorticoid, or saline: a randomized, double-blind, placebo-controlled trial. Am J Sports Med. 2013;41:625–35.CrossRefPubMed
17.
go back to reference Shiple BJ. How effective are injection treatments for lateral epicondylitis? Clin J Sport Med. 2013;23(6):502–3.CrossRefPubMed Shiple BJ. How effective are injection treatments for lateral epicondylitis? Clin J Sport Med. 2013;23(6):502–3.CrossRefPubMed
18.
go back to reference Dunkow PD, Jatti M, Muddu BN. A comparison of open and percutaneous techniques in the surgical treatment of tennis elbow. J Bone Joint Surg (Br). 2004;86(5):701–4.CrossRef Dunkow PD, Jatti M, Muddu BN. A comparison of open and percutaneous techniques in the surgical treatment of tennis elbow. J Bone Joint Surg (Br). 2004;86(5):701–4.CrossRef
19.
go back to reference Dunn JH, Kim J, Nirschl RP, et al. Ten- to 14-year follow-up of the Nirschl surgical technique for lateral epicondylitis. Am J Sports Med. 2008;36(2):261–6.CrossRefPubMed Dunn JH, Kim J, Nirschl RP, et al. Ten- to 14-year follow-up of the Nirschl surgical technique for lateral epicondylitis. Am J Sports Med. 2008;36(2):261–6.CrossRefPubMed
20.
go back to reference Coleman B, Quinlan JF, Matheson JA. Surgical treatment for lateral epicondylitis: a long-term follow-up of results. J Shoulder Elbow Surg. 2010;19(3):363–7.CrossRefPubMed Coleman B, Quinlan JF, Matheson JA. Surgical treatment for lateral epicondylitis: a long-term follow-up of results. J Shoulder Elbow Surg. 2010;19(3):363–7.CrossRefPubMed
21.
go back to reference Assendelft WJ, Hay EM, Adshead R, et al. Corticosteroid injections for lateral epicondylitis: a systematic review. B J Gen Prac. 1996;46(405):209–16. Assendelft WJ, Hay EM, Adshead R, et al. Corticosteroid injections for lateral epicondylitis: a systematic review. B J Gen Prac. 1996;46(405):209–16.
22.
go back to reference Wong MN, Tang YN, Lee SN, et al. Effect of dexamethasone on cultured human tenocytes and its reversibility by platelet-derived growth factor. J Bone Joint Surg Am. 2003;85(10):1914–20.PubMed Wong MN, Tang YN, Lee SN, et al. Effect of dexamethasone on cultured human tenocytes and its reversibility by platelet-derived growth factor. J Bone Joint Surg Am. 2003;85(10):1914–20.PubMed
23.
go back to reference Connell DA, Ali KE, Ahmad M, et al. Ultrasound guided autologous blood injection for tennis elbow. Skeletal Radiol. 2006;35(6):371–7.CrossRefPubMed Connell DA, Ali KE, Ahmad M, et al. Ultrasound guided autologous blood injection for tennis elbow. Skeletal Radiol. 2006;35(6):371–7.CrossRefPubMed
24.
go back to reference Edwards SG, Calandruccio JH. Autologous blood injections for refractory lateral epicondylitis. J Hand Surg Am. 2003;28(2):272–8.CrossRefPubMed Edwards SG, Calandruccio JH. Autologous blood injections for refractory lateral epicondylitis. J Hand Surg Am. 2003;28(2):272–8.CrossRefPubMed
25.
go back to reference Molloy T, Wang Y, Murrel G. The roles of growth factors in tendon and ligament healing. Am J Sports Med. 2003;33(5):381–94.CrossRef Molloy T, Wang Y, Murrel G. The roles of growth factors in tendon and ligament healing. Am J Sports Med. 2003;33(5):381–94.CrossRef
26.
go back to reference Thomopoulus S, Harwood F, Silva M, et al. Effect of several growth factors on canine flexor tendon fibroblast proliferation and collagen synthesis in vitro. J Hand Surg Am. 2005;30(3):441–7.CrossRef Thomopoulus S, Harwood F, Silva M, et al. Effect of several growth factors on canine flexor tendon fibroblast proliferation and collagen synthesis in vitro. J Hand Surg Am. 2005;30(3):441–7.CrossRef
27.
go back to reference Taylor MA, Norman TL, Clovis NB, et al. The response of rabbit patellar tendons after autologous blood injection. Med Sci Sports Exerc. 2002;34(1):70–3.CrossRefPubMed Taylor MA, Norman TL, Clovis NB, et al. The response of rabbit patellar tendons after autologous blood injection. Med Sci Sports Exerc. 2002;34(1):70–3.CrossRefPubMed
28.
go back to reference Anitua M, Sanchez E, Nurden A, et al. New insights into and novel applications for platelet-rich fibrin therapies. Trends Biotechnol. 2006;24(5):227–34.CrossRefPubMed Anitua M, Sanchez E, Nurden A, et al. New insights into and novel applications for platelet-rich fibrin therapies. Trends Biotechnol. 2006;24(5):227–34.CrossRefPubMed
29.
go back to reference Aspenberg P, Virchenko O. Platelet concentrate injection improves Achilles tendon repair in rats. Acta Orthop Scand. 2004;75(1):93–9.CrossRefPubMed Aspenberg P, Virchenko O. Platelet concentrate injection improves Achilles tendon repair in rats. Acta Orthop Scand. 2004;75(1):93–9.CrossRefPubMed
30.
31.
go back to reference Barrett S, Erredge S. Growth factors for chronic plantar fasciitis. Podiatry Today. 2004;17:37–42. Barrett S, Erredge S. Growth factors for chronic plantar fasciitis. Podiatry Today. 2004;17:37–42.
32.
go back to reference Kajikawa Y, Morihara T, Sakamoto H, Matsuda K, Oshima Y, Yoshida A, et al. Platelet-rich plasma enhances the initial mobilization of circulation-derived cells for tendon healing. J Cell Physiol. 2008;215(3):837–45.CrossRefPubMed Kajikawa Y, Morihara T, Sakamoto H, Matsuda K, Oshima Y, Yoshida A, et al. Platelet-rich plasma enhances the initial mobilization of circulation-derived cells for tendon healing. J Cell Physiol. 2008;215(3):837–45.CrossRefPubMed
33.
go back to reference Taylor M, Norman T, Clovis N, Blaha D. The response of rabbit patellar tendons after autologous blood injection. Med Sci Sports Exerc. 2002;34(1):70–3.CrossRefPubMed Taylor M, Norman T, Clovis N, Blaha D. The response of rabbit patellar tendons after autologous blood injection. Med Sci Sports Exerc. 2002;34(1):70–3.CrossRefPubMed
34.
go back to reference Sampson S, Gerhardt M. Platelet rich plasma injection grafts for musculoskeletal injuries: a review. Curr Rev Musculoskeletal Med. 2008;1:165–74.CrossRef Sampson S, Gerhardt M. Platelet rich plasma injection grafts for musculoskeletal injuries: a review. Curr Rev Musculoskeletal Med. 2008;1:165–74.CrossRef
35.
go back to reference Creaney L, Wallace A, Curtis M, Connell D. Growth factor-based therapies provide additional benefit beyond physical therapy in resistant elbow tendinopathy: a prospective, single-blind, randomized trial of autologous blood injections versus platelet-rich plasma. Brit J Sports Med. 2011;45(12):966–71.CrossRef Creaney L, Wallace A, Curtis M, Connell D. Growth factor-based therapies provide additional benefit beyond physical therapy in resistant elbow tendinopathy: a prospective, single-blind, randomized trial of autologous blood injections versus platelet-rich plasma. Brit J Sports Med. 2011;45(12):966–71.CrossRef
36.
go back to reference Thanasas C et al. Platelet-rich plasma versus autologous blood for the treatment for chronic lateral elbow epicondylitis: a randomized controlled clinical trial. Am J Sports Med. 2011;39(10):2130–4.CrossRefPubMed Thanasas C et al. Platelet-rich plasma versus autologous blood for the treatment for chronic lateral elbow epicondylitis: a randomized controlled clinical trial. Am J Sports Med. 2011;39(10):2130–4.CrossRefPubMed
Metadata
Title
A retrospective comparison of the management of recalcitrant lateral elbow tendinosis: platelet-rich plasma injections versus surgery
Authors
Ronald D. Ford
William P. Schmitt
Kyle Lineberry
Paul Luce
Publication date
01-06-2015
Publisher
Springer US
Published in
HAND / Issue 2/2015
Print ISSN: 1558-9447
Electronic ISSN: 1558-9455
DOI
https://doi.org/10.1007/s11552-014-9717-8

Other articles of this Issue 2/2015

HAND 2/2015 Go to the issue