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01-12-2015 | Case Report

A Report of Two Cases of Leptomeningeal Carcinomatosis Arising from Gallbladder Carcinoma

Authors: Dinesh Chandra Doval, Saud Azam, Rupal Sinha, Ullas Batra, Anurag Mehta, Avinash Rao

Published in: Journal of Gastrointestinal Cancer | Issue 4/2015

Excerpt

Gallbladder carcinoma (GBC) is a rare disease around most parts of the world but is common in the northern part of India, Japan, and Chile [1]. It is a very aggressive tumor which is diagnosed in the advanced stages and has very poor prognosis. The most common site of metastasis at the time of first diagnosis is the liver [2]. Least common sites of metastasis are lung, cerebral, and osseous [3]. Leptomeningeal carcinomatosis (LMC) is among the most serious complications in cancer, and in GBC, it is rarely reported. We report two cases of GBC with LMC during the treatment without metastasis in the central nervous system (CNS). …

Randi G, Malvezzi M, Levi F, Ferlay J, Negri E, Franceschi S, et al. Epidemiology of biliary tract cancers: an update. Ann Oncol. 2009;20:146–59.CrossRefPubMed

Win AZ, Aparici CM. Rare case of gallbladder cancer presenting with meta-stasis to bone and brain in an African American male discovered by F18-FDG PET/CT. J Biomed Graph Comput. 2013;3:24–9.

Marcal L, Viswanathan C, Szklaruk J. Computed tomography. In: Thomas CR, Fuller CD, editors. Biliary tract and gallbladder cancer: diagnosis and therapy. New York: Demos Medical Publishing; 2009. p. 141–66.

Deeb LS, Yamout BI, Shamseddine AI, et al. Meningeal carcinomatosis as the presenting manifestation of gastric adenocarcinoma. Am J Gastroenterol. 1997;92(2):329–31.PubMed

Kokkoris CP. Leptomeningeal carcinomatosis. How does cancer reach the pia-arachnoid? Cancer. 1983;51(1):154–60.CrossRefPubMed

Wasserstrom WR, Glass JP, Posner JB. Diagnosis and treatment of leptomeningeal metastases from solid tumors: experience with 90 patients. Cancer. 1982;49:759–72.CrossRefPubMed

Kusumoto T, Kimura Y, Sugiyama M, Ohta M, Tsutsumi N, Sakaguchi Y, et al. Leptomeningeal carcinomatosis originating from advanced gastric cancer—a report of three cases and review of the literatures. Fukuoka Igaku Zasshi. 2013;104(11):456–63.PubMed

Miyagui T, Luchemback L, Teixeira GH, de Azevedo KM. Meningeal carcinomatosis as the initial manifestation of a gallbladder adenocarcinoma associated with a Krukenberg tumor. Rev Hosp Clin Fac Med Sao Paulo. 2003;58(3):169–72.CrossRefPubMed

Hawkins D, Brown D. Meningeal carcinomatosis. Can Med Assoc J. 1963;88:225–8.PubMedCentralPubMed

10.

Thomas JE, Falls E, Velasco ME, et al. Diagnostic value of immunocytochemistry in leptomeningeal tumor dissemination—a report of two cases. Arch Pathol Lab Med. 2000;124(5):759–61.PubMed

11.

Jorda M, Ganjei-Azar P, Nadji M. Cytologic characteristics of meningeal carcinomatosis. Arch Neurol. 1998;55(2):181–94.CrossRefPubMed

12.

Gonzales-Vitale JC, Garcia-Bunuel R. Meningeal carcinomatosis. Cancer. 1976;37(6):2906–11.CrossRef

13.

Olson ME, Chernik NL, Posner JB. Infiltration of the leptomeninges by systemic cancer—a clinical and pathologic study. Arch Neurol. 1974;30(2):122–37.CrossRefPubMed

14.

Huffman JL, Yeatman TJ, Smith JB. Leptomeningeal carcinomatosis: a sequela of cholangiocarcinoma. Am Surg. 1997;63(4):310–3.PubMed

Title: A Report of Two Cases of Leptomeningeal Carcinomatosis Arising from Gallbladder Carcinoma
Authors: Dinesh Chandra Doval
Saud Azam
Rupal Sinha
Ullas Batra
Anurag Mehta
Avinash Rao
Publication date: 01-12-2015
Publisher: Springer US
Published in: Journal of Gastrointestinal Cancer / Issue 4/2015
Print ISSN: 1941-6628
Electronic ISSN: 1941-6636
DOI: https://doi.org/10.1007/s12029-015-9719-y

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