Top

Published in:

Open Access 01-12-2012 | Case Report

A rare case of malignant triton tumor in the cerebellopontine angle

Authors: Li Gong, Xiao-Yan Liu, Wen-Dong Zhang, Xiu-Juan Han, Li Yao, Shao-Jun Zhu, Miao Lan, Yan-Hong Li, Wei Zhang

Published in: Diagnostic Pathology | Issue 1/2012

Abstract

Malignant triton tumor (MTT) is defined as malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation. Intracranial MTT is extremely rare, and only four cases have been reported in the literature. Here, we report a case of MTT occurring in the cerebellopontine angle, and describe its histopathological characteristics, immunohistochemical features, and prognosis.

Virtual slides

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1336227313684480

Available only for authorised users

Ducatman BS, Scheithauer BW: Malignant peripheral nerve sheath tumors with divergent diVerentiation. Cancer. 1984, 54 (6): 1049-1057. 10.1002/1097-0142(19840915)54:6<1049::AID-CNCR2820540620>3.0.CO;2-1.CrossRefPubMed

Masson P: Reeklin ghausen’S neurofibromatosis,sensory neuromas and motor neuromas. 1932, International Press, New York, 793-802.

Brooks JSJ: Disorders of soft tissue. Diagnostic Surgical Pathology. Edited by: Sternberg SS. 1999, Lipincott Williams and Wilkins, Philadelphia, 131-221.

Yakulis R, Manack L, Murphy AI: Postradiation malignant triton tumor. A case report and review of the literature. Arch Pathol Lab Med. 1996, 120: 541-548.PubMed

Weiss SW, Goldblum JR: Malignant tumors of peripheral nerves. Enzinger and Weiss’s Soft Tissue Tumors. Edited by: Weiss SW, Goldblum JR. 2008, Mosby Elsevier, China, 903-944. 5

Zisis C, Fragoulis S, Rontogiani D, Stratakos G, Bellenis I: Malignant triton tumor of the anterior mediastinum as incidental finding: a case report. Monaldi Arch Chest Dis. 2006, 65: 22-24.

Hoshimoto S, Morise Z, Takeura C, Ikeda M, Kagawa T, Tanahashi Y, Okabe Y, Mizoguchi Y, Sugioka A: Malignant Triton tumor in the retroperitoneal space associated with neurofibromatosis type 1: a case study. Rare Tumors. 2009, 28 (1(2)): e27-

Qian WJ, Shen WS, Mao WD: A case report of malignant triton tumor in the right parapharyngeal space. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011, 46 (6): 519-520.PubMed

Prieto R, Pascual JM, García-Cabezas MA, López-Barea F, Barrios L, González-Llanos F: Low-grade malignant triton tumor in the lumbar spine: A rare variant of malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation. Neuropathology. 2011, [Epub ahead of print]

10.

Ghosh A, Sastri SB, Srinivas D, Mahadevan A, Anandappa CB, Shankar SK: Malignant triton tumor of cervical spine with hemorrhage. J Clin Neurosci. 2011, 18 (5): 721-723. 10.1016/j.jocn.2010.07.148.CrossRefPubMed

11.

Kabir S, Kapetanakis EI, Shabbo F: Intracardiac malignant Triton tumor: a first presentation. Ann Thorac Surg. 2010, 89 (3): 968-969. 10.1016/j.athoracsur.2009.07.052.CrossRefPubMed

12.

Potocka M, Skorek A, Izycka-Swieszewska E: Malignant Triton tumor of the nose–case report. Otolaryngol Pol. 2009, 63 (2): 165-167. 10.1016/S0030-6657(09)70100-3.CrossRefPubMed

13.

Tripathy K, Mallik R, Mishra A, Misra D, Rout N, Nayak P, Samantray S, Rath J: A Rare Malignant Triton Tumor. Case Rep Neurol. 2010, 2 (2): 69-73. 10.1159/000315621.PubMedCentralCrossRefPubMed

14.

Comey CH, McLaughlin MR, Jho HD, Martinez AJ, Lunsford LD: Death from a malignant cerebellopontine angle triton tumor despite stereotactic radiosurgery. Case report. J Neurosurg. 1998, 89 (4): 653-658. 10.3171/jns.1998.89.4.0653.CrossRefPubMed

15.

Han DH, Kim DG, Chi JG, Park SH, Jung HW, Kim YG: Malignant triton tumor of the acoustic nerve. Case report. J Neurosurg. 1992, 76 (5): 874-877. 10.3171/jns.1992.76.5.0874.CrossRefPubMed

16.

Best PV: Malignant triton tumour in the cerebellopontine angle. Report of a case. Acta Neuropathol. 1987, 74 (1): 92-96. 10.1007/BF00688345.CrossRefPubMed

17.

Woodruf JM, Chernik NL, Smith MC, Millett WB, Foote FW: Peripheral nerve tumors with rhabd0my0sarc0mat0us differentiation (malignant “Triton” tumors). Cancer. 1973, 32 (2): 426-439. 10.1002/1097-0142(197308)32:2<426::AID-CNCR2820320221>3.0.CO;2-W.CrossRef

18.

Kudo M, Matsumoto M, Terao H: Malignant nerve sheath tumor of acoustic nerve. Ach Pathol Lab Med. 1983, 107: 293-297.

19.

McConnell YJ, Giacomantonio CA: Malignant triton tumors-complete surgical resection and adjuvant radiotherapy associated with improved survival. J Surg Oncol. 2012, 10.1002/jso.23042. Jan 17

20.

Travis JA, Sandberg AA, NeV JR, Bridge JA: Cytogenetic Wndings in malignant triton tumor. Genes Chromosomes Cancer. 1994, 9: 1-7. 10.1002/gcc.2870090102.CrossRefPubMed

21.

McComb EN, McComb RD, DeBoner JM, NeV JR, Bridge JA: Cytogenetic analysis of a malignant triton tumor and a malignant peripheral nerve sheath tumor and a review of literature. Cancer Genet Cytogenet. 1996, 91: 8-12. 10.1016/S0165-4608(96)00125-2.CrossRefPubMed

22.

Henning Y, Löschke S, Katenkamp D, Bartnitzke S, Bullerdiek J: A malignant triton tumor with an unbalanced translocation (1;13) (q10;q10) and an isochromosome (8)(q10) as the sole karyotypic abnormalities. Cancer Genet Cytogenet. 2000, 118: 80-82. 10.1016/S0165-4608(99)00183-1.CrossRef

23.

Haddadin MH, Hawkins AL, Long P, Morsberger LA, Depew D, Epstein JI, GriYn CA: Cytogenetic study of malignant triton tumor: a case report. Cancer Genet Cytogenet. 2003, 144: 100-105. 10.1016/S0165-4608(02)00935-4.CrossRefPubMed

24.

Velagaleti GV, Miettinen M, Gatalica Z: Malignant peripheral nerve sheath tumor with rhabdomyoblastic diVerentiation (malignant triton tumor) with balanced t(7;9) (q11.2;p24) and unbalanced translocation der (16)t(1;16) (q23;q13). Cancer Genet Cytogenet. 2004, 149: 23-27. 10.1016/S0165-4608(03)00278-4.CrossRefPubMed

25.

Magrini E, Pragliola A, Fantasia D, Calabrese G, Gaiba A, Farnedi A, Collina G, Pession A: Acquisition of i(8q) as an early event in malignant triton tumors. Cancer Genet Cytogenet. 2004, 2: 150-155.CrossRef

26.

Koutsimpelas D, Brieger J, Heinrich U, Torzewski M, Sommer C, Mann WJ: Cytogenetic analysis of a malignant triton tumour by comparative genomic hybridization (CGH) and review of the literature. Eur Arch Otorhinolaryngol. 2011, 268 (9): 1391-1396. 10.1007/s00405-011-1658-z.CrossRefPubMed

Title: A rare case of malignant triton tumor in the cerebellopontine angle
Authors: Li Gong
Xiao-Yan Liu
Wen-Dong Zhang
Xiu-Juan Han
Li Yao
Shao-Jun Zhu
Miao Lan
Yan-Hong Li
Wei Zhang
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: Diagnostic Pathology / Issue 1/2012
Electronic ISSN: 1746-1596
DOI: https://doi.org/10.1186/1746-1596-7-43

At a glance: The STEP trials

Springer Medicine

A rare case of malignant triton tumor in the cerebellopontine angle

Abstract

Abstract

Virtual slides

At a glance: The STEP trials

Springer Medicine

Abstract

Abstract

Virtual slides

Please log in to get access to this content

Other articles of this Issue 1/2012

Idiopathic granulomatous mastitis associated with risperidone-induced hyperprolactinemia

Oncogenic reg IV is a novel prognostic marker for glioma patient survival

CD5-positive marginal zone B-cell lymphoma of the mucosa-associated lymphoid tissue (MALT) of the lung

Secondary cutaneous Epstein-Barr virus-associated diffuse large B-cell lymphoma in a patient with angioimmunoblastic T-cell lymphoma: a case report and review of literature

LMP1 and LMP2A are potential prognostic markers of extranodal NK/T-cell lymphoma, nasal type (ENKTL)

HLA-G and HLA-E specific mRNAs connote opposite prognostic significance in renal cell carcinoma