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01-12-2019 | Case Report

A Rare Case of a Metastatic Gastrointestinal Stromal Tumor (GIST): a Case Report and Review of the Literature

Authors: Hamzeh Saraireh, Obada Tayyem, Omar Al Asad, Ranjana Nawgiri, Issam Alawin

Published in: Journal of Gastrointestinal Cancer | Issue 4/2019

Excerpt

Gastrointestinal stromal tumors (GIST) are the most common mesenchymal neoplasms of gastrointestinal (GI) tract, accounting for less than 1% of all GI tumors. The incidence of GIST is estimated to be approximately 10–20 per million people, per year [1]. GISTs are typically seen in the stomach (50–60%), followed by small intestine (30–35%), colon and rectum (5%), and esophagus (< 1%) [2, 3]. There are only 38 cases of GISTs with metastasis to the bone that have been reported in the English literature [4‐28]. …

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Barrière J, Thariat J, Vandenbos F, Bondiau PY, Peyrottes I, Peyrade F. Diplopia as the first symptom of an aggressive metastatic rectal stromal tumor. Onkologie. 2009;32(6):345–7. https://doi.org/10.1159/000215712.CrossRefPubMed

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10.

Di Scioscio V, Greco L, Pallotti MC, Pantaleo MA, Maleddu A, Nannini M, et al. Three cases of bone metastases in patients with gastrointestinal stromal tumors. Rare Tumors. 2011;3(2):e17. https://doi.org/10.4081/rt.2011.e17.CrossRefPubMedPubMedCentral

11.

Aktan M, Koc M, Yavuz BB, Kanyilmaz G. Two cases of gastrointestinal stromal tumor of the small intestine with liver and bone metastasis. Ann Transl Med. 2015;3(17):259. https://doi.org/10.3978/j.issn.2305-5839.2015.09.46.CrossRefPubMedPubMedCentral

12.

Nakajima T, Sugiyama T, Baba H, Hatta H, Nishida T, Miwa S, et al. Bone metastasis in gastrointestinal stromal tumors preferentially occurs in patients with original tumors in sites other than the stomach. Int J Clin Exp Pathol. 2015;8(5):5955–9.PubMedPubMedCentral

13.

Sahin E, Yetişyiğit T, Oznur M, Elboğa U. Gastric gastrointestinal stromal tumor with bone metastases—case report and review of the literature. Klin Onkol. 2014;27(1):56–9. https://doi.org/10.14735/amko201456.CrossRefPubMed

14.

Selcukbiricik F, Tural D, Ozturk MA, Dervisoglu S, Sager S, Hız M, et al. Gastrointestinal stromal tumor of the rectum with scapular metastasis: a case report. J Med Case Rep. 2012;6(1):145. https://doi.org/10.1186/1752-1947-6-145.CrossRefPubMedPubMedCentral

15.

Slimack NP, Liu JC, Koski T, McClendon J, O’Shaughnessy BA. Metastatic gastrointestinal stromal tumor to the thoracic and lumbar spine: first reported case and surgical treatment. Spine J. 2012;12(1):e7–12. https://doi.org/10.1016/j.spinee.2011.10.037.CrossRefPubMed

16.

Abuzakhm SM, Acre-Lara CE, Zhao W, Hitchcock C, Mohamed N, Arbogast D, et al. Unusual metastases of gastrointestinal stromal tumor and genotypic correlates: case report and review of the literature. J Gastrointest Oncol. 2011;2(1):45–9. https://doi.org/10.3978/j.issn.2078-6891.2011.006.CrossRefPubMedPubMedCentral

17.

Tezcan Y, Koç M. Gastrointestinal stromal tumor of the rectum with bone and liver metastasis: a case study. Med Oncol. 2011;28(Suppl 1):S204–6.CrossRef

18.

Jain A, Dubashi B, Chandra SS, Halanaik D, Mangaladevi. Mesentric gastrointestinal stromal tumor with bone metastases. Indian J Cancer. 2011;48(3):383–4.CrossRef

19.

Baeg MK, Bae SH, Lee KH, Kim J, Park IS, Jin JY. Diplopia as a presenting symptom in a gastric gastrointestinal stromal tumor. Jpn J Clin Oncol. 2011;41(2):265–8. https://doi.org/10.1093/jjco/hyq176.CrossRefPubMed

20.

Li LF, Tse YH, Ho SL, Yan KW, Lui WM, Duodenal GIST. Metastasized to skull and orbit managed by surgery: a case report. Asian J Surg. 2011;34(4):181–4. https://doi.org/10.1016/j.asjsur.2011.11.001.CrossRefPubMed

21.

Wong CS, Chu YC. Intra-cranial metastasis of gastrointestinal stromal tumor. Chin Med J. 2011;124(21):3595–7.PubMed

22.

Lolli C, Pantaleo MA, Nannini M, Saponara M, Pallotti MC, Scioscio VD, et al. Successful radiotherapy for local control of progressively increasing metastasis of gastrointestinal stromal tumor. Rare Tumors. 2011;3(4):e49. https://doi.org/10.4081/rt.2011.e49.CrossRefPubMedPubMedCentral

23.

Zheng CK, Kan WS, Li PA. Case report of a metastatic gastrointestinal stromal tumor occurring in femur. Case Rep Gastrointest Med. 2011;2011:926179.PubMedPubMedCentral

24.

Romero-Rojas A, Mesa-Botero O, Melo-Uribe M, Chinchilla-Olaya S, Barajas-Solano P. Gastric gastrointestinal stromal tumor with unusual skull metastasis. Rev Col Gastroenterol. 2011;26:303–7.

25.

Ozan E, Oztekin O, Alacacioğlu A, Aykaş A, Postaci H, Adibelli Z. Esophageal gastrointestinal stromal tumor with pulmonary and bone metastases. Diagn Interv Radiol. 2010;16(3):217–20. https://doi.org/10.4261/1305-3825.DIR.1861-08.2.CrossRefPubMed

26.

Gil-Arnaiz I, Martínez-Trufero J, Pazo-Cid RA, Felipo F, Lecumberri MJ, Calderero V. Skull metastasis from rectal gastrointestinal stromal tumours. Clin Transl Oncol. 2009;11(9):625–7. https://doi.org/10.1007/s12094-009-0415-x.CrossRefPubMed

27.

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28.

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29.

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30.

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Title: A Rare Case of a Metastatic Gastrointestinal Stromal Tumor (GIST): a Case Report and Review of the Literature
Authors: Hamzeh Saraireh
Obada Tayyem
Omar Al Asad
Ranjana Nawgiri
Issam Alawin
Publication date: 01-12-2019
Publisher: Springer US
Published in: Journal of Gastrointestinal Cancer / Issue 4/2019
Print ISSN: 1941-6628
Electronic ISSN: 1941-6636
DOI: https://doi.org/10.1007/s12029-017-0037-4

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