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Orphanet Journal of Rare Diseases
Published in: Orphanet Journal of Rare Diseases 1/2011

Open Access 01-12-2011 | Review

A rare bladder cancer - small cell carcinoma: review and update

Author: Nabil Ismaili

Published in: Orphanet Journal of Rare Diseases | Issue 1/2011

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Abstract

Small cell carcinoma of the bladder (SCCB) is rare, highly aggressive and diagnosed mainly at advanced stages. Hematuria is the main symptom of this malignancy. The origin of the disease is unknown; however the multipotent stem cell theory applies best to this case. Histology and immunohistochemistry shows a tumour which is indistinguishable from small cell lung carcinoma (SCLC). Coexistence of SCCB with other types of carcinoma is common. The staging system used is the TNM-staging of bladder transitional cell carcinoma. The treatment is extrapolated from that of SCLC. However, many patients with SCCB undergo radical resection which is rarely performed in SCLC. Patients with surgically resectable disease (< or = cT1-4aN0M0) should be managed with multimodal therapy associating chemotherapy, surgery and/or radiotherapy. Neoadjuvant chemotherapy using four chemotherapy cycles followed by radical cystectomy is the most effective therapeutic sequence. Patients with unresectable disease (> or = cT4bN+M+) should be managed with palliative chemotherapy based on neuroendocrine type regimens comprising a platinum drug (cisplatin in fit patients). The prognosis of the disease is poor mainly in the case of pure small cell carcinoma. Other research programs are needed to improve the outcome of SCCB.
Appendix
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Literature
1.
Cramer SF, Aikawa M, Cebelin M: Neurosecretory granules in small cell invasive carcinoma of the urinary bladder. Cancer. 1981, 47 (4): 724-30. 10.1002/1097-0142(19810215)47:4<724::AID-CNCR2820470417>3.0.CO;2-2.CrossRefPubMed
2.
Blomjous CEM, Vos W, De Voogt HJ, van der Valk P, Meijer CJLM: Small cell carcinoma of the urinary bladder. A clinicopathologic, morphologic, immunohistochemical and ultrastructural study of 18 cases. Cancer. 1989, 64 (6): 1347-57. 10.1002/1097-0142(19890915)64:6<1347::AID-CNCR2820640629>3.0.CO;2-Q.CrossRefPubMed
3.
Holmang S, Borghede G, Johansson SL: Primary small cell carcinoma of the bladder: a report of 25 cases. J Urol. 1995, 153 (6): 1820-2. 10.1016/S0022-5347(01)67320-8.CrossRefPubMed
4.
Lohrisch C, Murray N, Pickles T, Sullivan L: Small cell carcinoma of the bladder: Long term outcome with integrated chemoradiation. Cancer. 1999, 86 (11): 2346-52. 10.1002/(SICI)1097-0142(19991201)86:11<2346::AID-CNCR24>3.0.CO;2-5.CrossRefPubMed
5.
Choong NW, Quevedo JF, Kaur JS: Small cell carcinoma of the urinary bladder. The Mayo Clinic experience. Cancer. 2005, 103 (6): 1172-8. 10.1002/cncr.20903.CrossRefPubMed
6.
Quek ML, Nichols PW, Yamzon J, Daneshmand S, Miranda G, Cai J, Groshen S, Stein JP, Skinner DG: Radical cystectomy for primary neuroendocrine tumors of the bladder: the university of southern California experience. J Urol. 2005, 174 (1): 93-6. 10.1097/01.ju.0000162085.20043.1f.CrossRefPubMed
7.
Ismaili N, Elkarak F, Heudel PE, Flechon A, Droz JP: Small cell cancer of the bladder: The Leon-Berard cancer centre experience. Indian J Urol. 2008, 24: 494-497. 10.4103/0970-1591.44255.PubMedCentralCrossRefPubMed
8.
Cheng L, Pan CX, Yang XJ, Lopez-Beltran A, MacLennan GT, Lin H, Kuzel TM, Papavero V, Tretiakova M, Nigro K, Koch MO, Eble JN: Small cell carcinoma of the urinary bladder: A clinicopathologic analysis of 64 patients. Cancer. 2004, 101 (5): 957-62. 10.1002/cncr.20456.CrossRefPubMed
9.
Abrahams NA, Moran C, Reyes AO, Siefker-Radtke A, Ayala AG: Small cell carcinoma of the bladder: a contemporary clinicopathological study of 51 cases. Histopathology. 2005, 46 (1): 57-63. 10.1111/j.1365-2559.2004.01980.x.CrossRefPubMed
10.
Bex A, Nieuwenhuijzen JA, Kerst M, Pos F, van Boven H, Meinhardt W, Horenblas S: Small cell carcinoma of bladder: a single-center prospective study of 25 cases treated in analogy to small cell lung cancer. Urology. 2005, 65 (2): 295-9. 10.1016/j.urology.2004.09.049.CrossRefPubMed
11.
Iczkowski KA, Shanks JH, Allsbrook WC, Lopez-Beltran A, Pantazis CG, Collins TR, Wetherington RW, Bostwick DG: Small cell carcinoma of urinary bladder is differentiated from urothelial carcinoma by chromogranin expression, absence of CD44 variant 6 expression, a unique pattern of cytokeratin expression, and more intense gamma-enolase expression. Histopathology. 1999, 35 (2): 150-6. 10.1046/j.1365-2559.1999.00715.x.CrossRefPubMed
12.
Siefker-Radtke AO, Dinney CP, Abrahams NA, Moran C, Shen Y, Pisters LL, Grossman HB, Swanson DA, Millikan RE: Evidence supporting preoperative chemotherapy for small cell carcinoma of the bladder: a retrospective review of the M. D. Anderson cancer experience. J Urol. 2004, 172 (2): 481-4. 10.1097/01.ju.0000132413.85866.fc.CrossRefPubMed
13.
Mukesh M, Cook N, Hollingdale AE, Ainsworth NL, Russell SG: Small cell carcinoma of the urinary bladder: a 15-year retrospective review of treatment and survival in the Anglian Cancer Network. BJU Int. 2009, 103 (6): 747-52. 10.1111/j.1464-410X.2008.08241.x.CrossRefPubMed
14.
Mangar SA, Logue JP, Shanks JH, Cooper RA, Cowan RA, Wylie JP: Small-cell carcinoma of the urinary bladder: 10-year experience. Clin Oncol (R Coll Radiol). 2004, 16 (8): 523-7. 10.1016/j.clon.2004.06.024.CrossRef
15.
Bex A, de Vries R, Pos F, Kerst M, Horenblas S: Long-term survival after sequential chemoradiation for limited disease small cell carcinoma of the bladder. World J Urol. 2009, 27 (1): 101-6. 10.1007/s00345-008-0304-x.CrossRefPubMed
16.
Ali SZ, Reuter VE, Zakowski MF: Small cell neuroendocrine carcinoma of the urinary bladder: a clinicopathologic study with emphasis on cytologic features. Cancer. 1997, 79: 356-361. 10.1002/(SICI)1097-0142(19970115)79:2<356::AID-CNCR19>3.0.CO;2-#.CrossRefPubMed
17.
Oesterling JE, Brendler CB, Burgers JK, Marshall FF, Epstein JI: Advanced small cell carcinoma of the bladder. Successful treatment with combined radical cystoprostatectomy and adjuvant methotrexate, vinblastine, doxorubicin, and cisplatin chemotherapy. Cancer. 1990, 65 (9): 1928-36. 10.1002/1097-0142(19900501)65:9<1928::AID-CNCR2820650910>3.0.CO;2-X.CrossRefPubMed
18.
Terracciano L, Richter J, Tornillo L, Beffa L, Diener PA, Maurer R, Gasser TC, Moch H, Mihatsch MJ, Sauter G: Chromosomal imbalances in small cell carcinomas of the urinary bladder. J Pathol. 1999, 189 (2): 230-5. 10.1002/(SICI)1096-9896(199910)189:2<230::AID-PATH407>3.0.CO;2-8.CrossRefPubMed
19.
Christopher ME, Seftel AD, Sorenson K, Resnick MI: Small cell carcinoma of the genitourinary tract: an immunohistochemical, electron microscopic and clinicopathological study. J Urol. 1991, 146 (2): 382-8.PubMed
20.
van Hoeven KH, Artymyshyn RL: Cytology of small cell carcinoma of the urinary bladder. Diagn Cytopathol. 1996, 14 (4): 292-7. 10.1002/(SICI)1097-0339(199605)14:4<292::AID-DC3>3.0.CO;2-I.CrossRefPubMed
21.
Reyes CV, Soneru I: Small cell carcinoma of the urinary bladder with hypercalcemia. Cancer. 1985, 56 (10): 2530-3. 10.1002/1097-0142(19851115)56:10<2530::AID-CNCR2820561035>3.0.CO;2-4.CrossRefPubMed
22.
Sved P, Gomez P, Manoharan M, Civantos F, Soloway MS: Small cell carcinoma of the bladder. BJU Int. 2004, 94 (1): 12-7. 10.1111/j.1464-410X.2003.04893.x.CrossRefPubMed
23.
Grignon DJ, Ro JY, Ayala AG, Shum DT, Ordóñez NG, Logothetis CJ, Johnson DE, Mackay B: Small cell carcinoma of the urinary bladder. A clinicopathologic analysis of 22 cases. Cancer. 1992, 69 (2): 527-36. 10.1002/1097-0142(19920115)69:2<527::AID-CNCR2820690241>3.0.CO;2-7.CrossRefPubMed
24.
Jones TD, Kernek KM, Yang XJ, Lopez-Beltran A, MacLennan GT, Eble JN, Lin H, Pan CX, Tretiakova M, Baldridge LA, Cheng L: Thyroid transcription factor 1 expression in small cell carcinoma of the urinary bladder: an immunohistochemical profile of 44 cases. Hum Pathol. 2005, 36 (7): 718-23. 10.1016/j.humpath.2005.04.007.CrossRefPubMed
25.
Agoff SN, Lamps LW, Philip AT, Amin MB, Schmidt RA, True LD, Folpe AL: Thyroid transcription factor-1 is expressed in extrapulmonary small cell carcinomas but not in other extrapulmonary neuroendocrine tumors. Mod Pathol. 2000, 13 (3): 238-42. 10.1038/modpathol.3880044.CrossRefPubMed
26.
Wang X, Zhang S, MacLennan GT, Eble JN, Lopez-Beltran A, Yang XJ, Pan CX, Zhou H, Montironi R, Cheng L: Epidermal growth factor receptor protein expression and gene amplification in small cell carcinoma of the urinary bladder. Clin Cancer Res. 2007, 13 (3): 953-7. 10.1158/1078-0432.CCR-06-2167.CrossRefPubMed
27.
Pan CX, Yang XJ, Lopez-Beltran A, MacLennan GT, Eble JN, Koch MO, Jones TD, Lin H, Nigro K, Papavero V, Tretiakova M, Cheng L: c-kit Expression in small cell carcinoma of the urinary bladder: prognostic and therapeutic implications. Mod Pathol. 2005, 18 (3): 320-3. 10.1038/modpathol.3800318.CrossRefPubMed
28.
Terada T: Autopsy case of primary small cell carcinoma of the urinary bladder: KIT and PDGFRA expression and mutations. Pathol Int. 2009, 59 (4): 247-50. 10.1111/j.1440-1827.2009.02358.x.CrossRefPubMed
29.
Léonard C, Huret JL, Gfco; Groupe français, de cytogénétique oncologique: From cytogenetics to cytogenomics of bladder cancers. Bull Cancer. 2002, 89 (2): 166-73.PubMed
30.
Church DN, Bahl A: Clinical review - small cell carcinoma of the bladder. Cancer Treat Rev. 2006, 32 (8): 588-93. 10.1016/j.ctrv.2006.07.013.CrossRefPubMed
31.
Ismaili N, Ghanem S, Mellas N, Afqir S, Taleb M, Amrani M, Gamra L, Errihani H: Small cell carcinoma of the urinary bladder: a case report and review of the literature. J Cancer Res Ther. 2009, 5 (2): 133-6. 10.4103/0973-1482.52790.CrossRefPubMed
32.
Bastús R, Caballero JM, González G, Borrat P, Casalots J, Gomez de Segura G, Martí LI, Ristol J, Cirera L: Small cell carcinoma of the urinary bladder treated with chemotherapy and radiotherapy: Results in five cases. Eur Urol. 1999, 35 (4): 323-6. 10.1159/000019870.CrossRefPubMed
33.
Siefker-Radtke AO, Kamat AM, Grossman HB, Williams DL, Qiao W, Thall PF, Dinney CP, Millikan RE: Phase II clinical trial of neoadjuvant alternating doublet chemotherapy with ifosfamide/doxorubicin and etoposide/cisplatin in small-cell urothelial cancer. J Clin Oncol. 2009, 27 (16): 2592-7. 10.1200/JCO.2008.19.0256.CrossRefPubMed
34.
Ismaili N, Heudel PE, Elkarak F, Kaikani W, Bajard A, Ismaili M, Errihani H, Droz JP, Flechon A: Outcome of recurrent and metastatic small cell carcinoma of the bladder. BMC Urol. 2009, 9: 4. 10.1186/1471-2490-9-4.PubMedCentralCrossRefPubMed
35.
Mackey JR, Au HJ, Hugh J, Venner P: Genitourinary small cell carcinoma: determination of clinical and therapeutic factors associated with survival. J Urol. 1998, 159: 1624-1629. 10.1097/00005392-199805000-00058.CrossRefPubMed
36.
Ismaili N, Amzerin M, Elmajjaoui S, Droz JP, Flechon A, Errihani H: The role of chemotherapy in the management of bladder cancer. Prog Urol. 2011, 21 (6): 369-82.CrossRefPubMed
37.
Ismaili N, Elmajjaoui S, Bensouda Y, Belbaraka R, Abahssain H, Allam W, Fadoukhair Z, Mesmoudi M, Tanz R, Mahfoud T, Elomrani A, Khouchani M, Sbitti Y, Benjaafar N, Errihani H, Tahri A: Neoadjuvant or adjuvant chemotherapy: what is the best treatment of muscle invasive bladder cancer?. Oncol Rev. 2011, 5 (3): 185-189. 10.1007/s12156-011-0085-0.CrossRef
38.
Black PC, Brown GA, Dinney CP: The impact of variant histology on the outcome of bladder cancer treated with curative intent. Urol Oncol. 2009, 27 (1): 3-7. 10.1016/j.urolonc.2007.07.010.CrossRefPubMed
39.
Pan CX, Zhang H, Lara PN, Cheng L: Small-cell carcinoma of the urinary bladder: diagnosis and management. Expert Rev Anticancer Ther. 2006, 6 (12): 1707-13. 10.1586/14737140.6.12.1707.CrossRefPubMed
40.
Bex A, Sonke GS, Pos FJ, Brandsma D, Kerst JM, Horenblas S: Symptomatic brain metastases from small-cell carcinoma of the urinary bladder: The Netherlands Cancer Institute experience and literature review. Ann Oncol. 2010, 21 (11): 2240-5. 10.1093/annonc/mdq225.CrossRefPubMed
41.
June RR, Dougherty DW, Reese CT, Harpster LE, Hoffman SL, Drabick JJ: Significant activity of single agent vinorelbine against small-cell cancer of the bladder as second line chemotherapy: A case series and review of the literature. Urol Oncol. 2010.
42.
Puglisi M, Dolly S, Faria A, Myerson JS, Popat S, O'Brien ME: Treatment options for small cell lung cancer - do we have more choice?. Br J Cancer. 2010, 102 (4): 629-38. 10.1038/sj.bjc.6605527.PubMedCentralCrossRefPubMed
43.
Ismaili N, Arifi S, Flechon A, El Mesbahi O, Blay JY, Droz JP, Errihani H: Small cell cancer of the bladder: pathology, diagnosis, treatment and prognosis. Bull Cancer. 2009, 96 (6): E30-44.PubMed
44.
Pant-Purohit M, Lopez-Beltran A, Montironi R, MacLennan GT, Cheng L: Small cell carcinoma of the urinary bladder. Histol Histopathol. 2010, 25 (2): 217-21.PubMed
45.
Wang X, MacLennan GT, Lopez-Beltran A, Cheng L: Small cell carcinoma of the urinary bladder--histogenesis, genetics, diagnosis, biomarkers, treatment, and prognosis. Appl Immunohistochem Mol Morphol. 2007, 15 (1): 8-18. 10.1097/01.pai.0000213106.12731.d7.CrossRefPubMed
Metadata
Title
A rare bladder cancer - small cell carcinoma: review and update
Author
Nabil Ismaili
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Orphanet Journal of Rare Diseases / Issue 1/2011
Electronic ISSN: 1750-1172
DOI
https://doi.org/10.1186/1750-1172-6-75

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