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Published in: Breast Cancer Research 6/2010

01-12-2010 | Letter

A prophylactic vaccine for breast cancer? Why not?

Author: Vincent K Tuohy

Published in: Breast Cancer Research | Issue 6/2010

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Excerpt

In a recent issue of Breast Cancer Research, Watson and Gusterson wrote a viewpoint article [1] about our strategy for developing a prophylactic breast cancer vaccine [2]. The authors base much of their view on several misconceptions and misrepresentations that we wish to clarify. …
Literature
2.
go back to reference Jaini R, Kesaraju P, Johnson JM, Altuntas CZ, Jane-Wit D, Tuohy VK: An autoimmune-mediated strategy for prophylactic breast cancer vaccination. Nat Med. 2010, 16: 799-803. 10.1038/nm.2161.CrossRefPubMedPubMedCentral Jaini R, Kesaraju P, Johnson JM, Altuntas CZ, Jane-Wit D, Tuohy VK: An autoimmune-mediated strategy for prophylactic breast cancer vaccination. Nat Med. 2010, 16: 799-803. 10.1038/nm.2161.CrossRefPubMedPubMedCentral
3.
go back to reference Robinson GW, McKnight RA, Smith GH, Hennighausen L: Mammary epithelial cells undergo secretory differentiation in cycling virgins but require pregnancy for the establishment of terminal differentiation. Development. 1995, 121: 2079-2090.PubMed Robinson GW, McKnight RA, Smith GH, Hennighausen L: Mammary epithelial cells undergo secretory differentiation in cycling virgins but require pregnancy for the establishment of terminal differentiation. Development. 1995, 121: 2079-2090.PubMed
4.
go back to reference Kleinberg DL, Todd J: α-Lactalbumin in human and subhuman primate normal mammary tissue and in human breast cancer as a marker for prolactin activity. Cancer Res. 1978, 38: 4318-4322.PubMed Kleinberg DL, Todd J: α-Lactalbumin in human and subhuman primate normal mammary tissue and in human breast cancer as a marker for prolactin activity. Cancer Res. 1978, 38: 4318-4322.PubMed
5.
go back to reference Walker RA: The demonstration of alpha lactalbumin in human breast carcinomas. J Pathol. 1979, 129: 37-42. 10.1002/path.1711290107.CrossRefPubMed Walker RA: The demonstration of alpha lactalbumin in human breast carcinomas. J Pathol. 1979, 129: 37-42. 10.1002/path.1711290107.CrossRefPubMed
6.
go back to reference Martin RH, Glass MR, Chapman C, Wilson GD, Woods KL: Suppression by bromocriptine of the serum lactalbumin peak associated with human lactogenesis. Clin Endocrinol (Oxf). 1981, 14: 363-366. 10.1111/j.1365-2265.1981.tb00621.x.CrossRef Martin RH, Glass MR, Chapman C, Wilson GD, Woods KL: Suppression by bromocriptine of the serum lactalbumin peak associated with human lactogenesis. Clin Endocrinol (Oxf). 1981, 14: 363-366. 10.1111/j.1365-2265.1981.tb00621.x.CrossRef
7.
go back to reference Clayton F, Sibley RK, Ordonez NG, Hanssen G: Argyrophilic breast carcinomas: evidence of lactational differentiation. Am J Surg Pathol. 1982, 6: 323-333. 10.1097/00000478-198206000-00005.CrossRefPubMed Clayton F, Sibley RK, Ordonez NG, Hanssen G: Argyrophilic breast carcinomas: evidence of lactational differentiation. Am J Surg Pathol. 1982, 6: 323-333. 10.1097/00000478-198206000-00005.CrossRefPubMed
8.
go back to reference Lee AK, DeLellis RA, Rosen PP, Herbert-Stanton T, Tallberg K, Garcia C, Wolfe HJ: Alpha-lactalbumin as an immunohistochemical marker for metastatic breast carcinomas. Am J Surg Pathol. 1984, 8: 93-100. 10.1097/00000478-198402000-00002.CrossRefPubMed Lee AK, DeLellis RA, Rosen PP, Herbert-Stanton T, Tallberg K, Garcia C, Wolfe HJ: Alpha-lactalbumin as an immunohistochemical marker for metastatic breast carcinomas. Am J Surg Pathol. 1984, 8: 93-100. 10.1097/00000478-198402000-00002.CrossRefPubMed
9.
go back to reference Lee AK, Rosen PP, DeLellis RA, Saigo PE, Gangi MD, Groshen S, Bagin R, Wolfe HJ: Tumor marker expression in breast carcinomas and relationship to prognosis. An immunohistochemical study. Am J Clin Pathol. 1985, 84: 687-696.CrossRefPubMed Lee AK, Rosen PP, DeLellis RA, Saigo PE, Gangi MD, Groshen S, Bagin R, Wolfe HJ: Tumor marker expression in breast carcinomas and relationship to prognosis. An immunohistochemical study. Am J Clin Pathol. 1985, 84: 687-696.CrossRefPubMed
10.
go back to reference Cohen C, Sharkey FE, Shulman G, Uthman EO, Budgeon LR: Tumor associated antigens in breast carcinomas. Prognostic significance. Cancer. 1987, 60: 1294-1298. 10.1002/1097-0142(19870915)60:6<1294::AID-CNCR2820600622>3.0.CO;2-2.CrossRefPubMed Cohen C, Sharkey FE, Shulman G, Uthman EO, Budgeon LR: Tumor associated antigens in breast carcinomas. Prognostic significance. Cancer. 1987, 60: 1294-1298. 10.1002/1097-0142(19870915)60:6<1294::AID-CNCR2820600622>3.0.CO;2-2.CrossRefPubMed
11.
go back to reference Wrba F, Reiner A, Markis-Ritzinger E, Holzner JH, Reiner G, Spona J: Prognostic significance of immunohistochemical parameters in breast carcinomas. Pathol Res Pract. 1988, 183: 277-283.CrossRefPubMed Wrba F, Reiner A, Markis-Ritzinger E, Holzner JH, Reiner G, Spona J: Prognostic significance of immunohistochemical parameters in breast carcinomas. Pathol Res Pract. 1988, 183: 277-283.CrossRefPubMed
12.
go back to reference Li X, Zhang J, Gao H, Vieth E, Bae KH, Zhang YP, Lee SJ, Raikwar S, Gardner TA, Hutchins GD, VanderPutten D, Kao C, Jeng MH: Transcriptional targeting modalities in breast cancer gene therapy using adenovirus vectors controlled by alpha-lactalbumin promoter. Mol Cancer Ther. 2005, 4: 1850-1859. 10.1158/1535-7163.MCT-05-0167.CrossRefPubMed Li X, Zhang J, Gao H, Vieth E, Bae KH, Zhang YP, Lee SJ, Raikwar S, Gardner TA, Hutchins GD, VanderPutten D, Kao C, Jeng MH: Transcriptional targeting modalities in breast cancer gene therapy using adenovirus vectors controlled by alpha-lactalbumin promoter. Mol Cancer Ther. 2005, 4: 1850-1859. 10.1158/1535-7163.MCT-05-0167.CrossRefPubMed
13.
go back to reference Anderson LM, Swaminathan S, Zackon I, Tajuddin AK, Thimmapaya B, Weitzman SA: Adenovirus-mediated tissue-targeted expression of the HSVtk gene for the treatment of breast cancer. Gene Ther. 1999, 6: 854-864. 10.1038/sj.gt.3300909.CrossRefPubMed Anderson LM, Swaminathan S, Zackon I, Tajuddin AK, Thimmapaya B, Weitzman SA: Adenovirus-mediated tissue-targeted expression of the HSVtk gene for the treatment of breast cancer. Gene Ther. 1999, 6: 854-864. 10.1038/sj.gt.3300909.CrossRefPubMed
14.
go back to reference Anderson LM, Krotz S, Weitzman SA, Thimmapaya B: Breast cancer-specific expression of the Candida albicans cytosine deaminase gene using a transcriptional targeting approach. Cancer Gene Ther. 2000, 7: 845-852. 10.1038/sj.cgt.7700191.CrossRefPubMed Anderson LM, Krotz S, Weitzman SA, Thimmapaya B: Breast cancer-specific expression of the Candida albicans cytosine deaminase gene using a transcriptional targeting approach. Cancer Gene Ther. 2000, 7: 845-852. 10.1038/sj.cgt.7700191.CrossRefPubMed
15.
go back to reference Thomas DL, Fraser NW: HSV-1 Therapy of primary tumors reduces the number of metastases in an immune-competent model of metastatic breast cancer. Mol Ther. 2003, 8: 543-551. 10.1016/S1525-0016(03)00236-3.CrossRefPubMed Thomas DL, Fraser NW: HSV-1 Therapy of primary tumors reduces the number of metastases in an immune-competent model of metastatic breast cancer. Mol Ther. 2003, 8: 543-551. 10.1016/S1525-0016(03)00236-3.CrossRefPubMed
16.
go back to reference Bailey AJ, Sloane JP, Trickey BS, Ormerod MG: An immunocytochemical study of α-lactalbumin in human breast tissue. J Pathol. 1982, 137: 13-23. 10.1002/path.1711370103.CrossRefPubMed Bailey AJ, Sloane JP, Trickey BS, Ormerod MG: An immunocytochemical study of α-lactalbumin in human breast tissue. J Pathol. 1982, 137: 13-23. 10.1002/path.1711370103.CrossRefPubMed
Metadata
Title
A prophylactic vaccine for breast cancer? Why not?
Author
Vincent K Tuohy
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 6/2010
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2775

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