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01-03-2014 | Functional Neuroradiology

A preliminary diffusional kurtosis imaging study of Parkinson disease: comparison with conventional diffusion tensor imaging

Authors: Koji Kamagata, Hiroyuki Tomiyama, Taku Hatano, Yumiko Motoi, Osamu Abe, Keigo Shimoji, Kouhei Kamiya, Michimasa Suzuki, Masaaki Hori, Mariko Yoshida, Nobutaka Hattori, Shigeki Aoki

Published in: Neuroradiology | Issue 3/2014

Abstract

Introduction

Diffusional kurtosis imaging (DKI) is a more sensitive technique than conventional diffusion tensor imaging (DTI) for assessing tissue microstructure. In particular, it quantifies the microstructural integrity of white matter, even in the presence of crossing fibers. The aim of this preliminary study was to compare how DKI and DTI show white matter alterations in Parkinson disease (PD).

Methods

DKI scans were obtained with a 3-T magnetic resonance imager from 12 patients with PD and 10 healthy controls matched by age and sex. Tract-based spatial statistics were used to compare the mean kurtosis (MK), mean diffusivity (MD), and fractional anisotropy (FA) maps of the PD patient group and the control group. In addition, a region-of-interest analysis was performed for the area of the posterior corona radiata and superior longitudinal fasciculus (SLF) fiber crossing.

Results

FA values in the frontal white matter were significantly lower in PD patients than in healthy controls. Reductions in MK occurred more extensively throughout the brain: in addition to frontal white matter, MK was lower in the parietal, occipital, and right temporal white matter. The MK value of the area of the posterior corona radiata and SLF fiber crossing was also lower in the PD group.

Conclusion

DKI detects changes in the cerebral white matter of PD patients more sensitively than conventional DTI. In addition, DKI is useful for evaluating crossing fibers. By providing a sensitive index of brain pathology in PD, DKI may enable improved monitoring of disease progression.

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Title: A preliminary diffusional kurtosis imaging study of Parkinson disease: comparison with conventional diffusion tensor imaging
Authors: Koji Kamagata
Hiroyuki Tomiyama
Taku Hatano
Yumiko Motoi
Osamu Abe
Keigo Shimoji
Kouhei Kamiya
Michimasa Suzuki
Masaaki Hori
Mariko Yoshida
Nobutaka Hattori
Shigeki Aoki
Publication date: 01-03-2014
Publisher: Springer Berlin Heidelberg
Published in: Neuroradiology / Issue 3/2014
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-014-1327-1

At a glance: The STEP trials

Springer Medicine

A preliminary diffusional kurtosis imaging study of Parkinson disease: comparison with conventional diffusion tensor imaging

Abstract

Introduction

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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