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Trials
Published in: Trials 2/2015

Open Access 01-12-2015 | Poster presentation

A pragmatic approach to the design and calibration of a Bayesian CRM dose finding trial

Authors: Michael Cole, Deborah Stocken, Christina Yap

Published in: Trials | Special Issue 2/2015

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Excerpt

The Continual Reassessment Method (CRM) is not widely used in early phase dose finding trials partly because the logistics of development and implementation are perceived as complex and time consuming. Details are presented of the steps involved when designing such a trial using an adaptation of a Bayesian CRM calibration algorithm proposed by Cheung [1]. …
Literature
1.
Cheung YK: Dose Finding by the Continual Reassessment Method. 2011, New York: Chapman & Hall/CRC PressCrossRef
Metadata
Title
A pragmatic approach to the design and calibration of a Bayesian CRM dose finding trial
Authors
Michael Cole
Deborah Stocken
Christina Yap
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Trials / Issue Special Issue 2/2015
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/1745-6215-16-S2-P210

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