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Annals of Nuclear Medicine
Published in: Annals of Nuclear Medicine 4/2015

01-05-2015 | Original Article

A novel respiratory gating method for oncologic positron emission tomography based on bioimpedance approach

Authors: Tuomas Koivumäki, Jarmo Teuho, Mika Teräs, Marko Vauhkonen, Mikko A. Hakulinen

Published in: Annals of Nuclear Medicine | Issue 4/2015

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Abstract

Objective

Respiratory motion causes loss of image quality and inaccuracy of quantification in oncologic positron emission tomography (PET) imaging. This study introduces a bioimpedance-based gating method for compensation of respiratory motion artefacts.

Methods

The bioimpedance-based respiratory gating method was studied parallel to a clinically used respiratory gating method [Real-time Position Management by Varian Medical Systems] in 4D PET/CT acquisition of 9 oncologic patients. The quantitative analysis consisted of the evaluation of tumour SUVpeak, SUVmax and volume. Additionally, target-to-background ratios as well as motion in cranial–caudal and anterior–posterior directions were measured. The evaluation was performed with amplitude- and time-based gating using averaged attenuation correction maps.

Results

Bioimpedance gating resulted in 17.7–18.9 % increase in mean SUVpeak and 20.0–21.4 % decrease in mean volume compared to non-gated images. The maximum motion measured from the bioimpedance-gated images was 19 mm in cranial–caudal direction and 9 mm in anterior–posterior direction.

Conclusions

Bioimpedance-based respiratory gating compensates the adverse effects of motion in oncologic PET imaging.
Literature
1.
Nehmeh SA, Erdi YU, Ling CC, Rosenzweig KE, Schoder H, Larson SM, et al. Effect of respiratory gating on quantifying PET images in lung cancer. J Nucl Med. 2002;43:876–81.PubMed
2.
Liu C, Pierce LA, Alessio AM, Kinahan PE. The impact of respiratory motion on tumor quantification and delineation in static PET/CT imaging. Phys Med Biol. 2009;54:7345–62.CrossRefPubMedCentralPubMed
3.
Dawood M, Büther F, Lang N, Schober O, Schäfers KP. Respiratory gating in positron emission tomography: a quantitative comparison of different gating schemes. Med Phys. 2007;34:3067–76.CrossRefPubMed
4.
Bundschuh RA, Martinéz-Moeller A, Essler M, Martinéz J-M, Nekolla SG, Ziegler SI, et al. Postacquisition detection of tumor motion in the lung and upper abdomen using list-mode PET data: a feasibility study. J Nucl Med. 2007;48:758–63.CrossRefPubMed
5.
Chang G, Chang T, Clark JW Jr, Mawlawi OR. Design and performance of a respiratory amplitude gating device for PET/CT imaging. Med Phys. 2010;37:1408–12.CrossRefPubMedCentralPubMed
6.
Wolthaus JWH, van Herk M, Muller SH, Belderlos JSA, Lebesque JV, de Bois JA, et al. Fusion of respiration-correlated PET and CT scans: correlated lung tumour motion in anatomical and functional scans. Phys Med Biol. 2005;50:1569–83.CrossRefPubMed
7.
Schleyer PJ, O’Doherty MJ, Barrington SF, Marsden PK. Retrospective data-driven respiratory gating for PET/CT. Phys Med Biol. 2009;54:1935–50.CrossRefPubMed
8.
Büther F, Ernst I, Dawood M, Kraxner P, Schäfers M, Schober O, et al. Detection of respiratory tumour motion using intrinsic list-mode-driven gating in positron emission tomography. Eur J Nucl Med Mol Imaging. 2010;37:2315–27.CrossRefPubMed
9.
Fin L, Daouk J, Morvan J, Bailly P, El Esper I, Saidi L, et al. Initial clinical results for breath-hold CT-based processing of respiratory-gated PET acquisitions. Eur J Nucl Med Mol Imaging. 2008;35:1971–80.CrossRefPubMed
10.
Büther F, Ernst I, Hamill J, Eich HT, Schober O, Schäfers M, et al. External radioactive markers for PET data-driven respiratory gating in positron emission tomography. Eur J Nucl Med Mol Imaging. 2012;40:602–14.CrossRefPubMed
11.
Lamare F, Ledesma Carbayo MJ, Cresson T, Kontaxakis G, Santos A, Cheze Le Rest C, et al. List-mode-based reconstruction for respiratory motion correction in PET using non-rigid body transformations. Phys Med Biol. 2007;52:5187–204.CrossRefPubMed
12.
Bundschuh RA, Martinéz-Moeller A, Essler M, Nekolla SG, Ziegler SI, Schwaiger M. Local motion correction for lung tumours in PET/CT—first results. Eur J Nucl Med Mol Imaging. 2008;35:1981–8.CrossRefPubMed
13.
Nehmeh SA, Erdi YU, Meirelles GSP, Squire O, Larson SM, et al. Deep-inspiration breath-hold PET/CT of the thorax. J Nucl Med. 2007;48:22–6.PubMed
14.
Kawano T, Ohtake E, Inoue T. Deep-inspiration breath-hold PET/CT of lung cancer: maximum standardized uptake value analysis of 108 patients. J Nucl Med. 2008;49:1223–31.CrossRefPubMed
15.
Koch N, Liu HH, Starkschall G, Jacobson M, Forster K, Liao Z, et al. Evaluation of internal lung motion for respiratory-gated radiotherapy using MRI: part I—correlating internal lung motion with skin fiducial motion. Int J Radiation Oncology Biol Phys. 2004;60:1459–72.CrossRef
16.
Didierlaurent D, Ribes S, Batatia H, Jaudet C, Dierickx LO, Zerdoud S, et al. The retrospective binning method improves the consistency of phase binning in respiratory-gated PET/CT. Phys Med Biol. 2012;57:7829–41.CrossRefPubMed
17.
Nehmeh SA, Erdi YE. Respiratory motion in positron emission tomography/computed tomography: a review. Semin Nucl Med. 2008;38:167–76.CrossRefPubMed
18.
Houtveen JH, Groot PF, de Geus EJ. Validation of the thoracic impedance derived respiratory signal using multilevel analysis. Int J Psychophysiol. 2006;59:97–106.CrossRefPubMed
19.
Koivumäki T, Kuikka JT, Vauhkonen M, Hakulinen MA. Bioimpedance-based measurement method for simultaneous acquisition of respiratory and cardiac gating signals. Physiol Meas. 2012;33:1323–34.CrossRefPubMed
20.
Baker LE. Applications of the impedance technique to the respiratory system. IEEE Eng Med Biol Mag. 1989;8:50–2.CrossRefPubMed
21.
Cho K, Kumiata S, Okada S, Kumazaki T. Development of respiratory gated myocardial SPECT system. J Nucl Cardiol. 1999;6:20–8.CrossRefPubMed
22.
Conwell R, Bai C, Kindem J, Babla H, Solis D, De Los Santos R, et al. An operator-passive thoracic impedance approach for respiratory motion gating in myocardial perfusion SPECT. IEEE Nucl Sci Symp Conf Rec. 2011;23–29:3888–93.
23.
Koivumäki T, Vauhkonen M, Kuikka JT, Hakulinen MA. Optimizing bioimpedance measurement configuration for dual-gated nuclear medicine imaging: a sensitivity study. Med Biol Eng Comput. 2011;49:783–91.CrossRefPubMed
24.
Wahl RL, Jacene H, Kasamon Y, Lodge MA. From RECIST to PERCIST: evolving considerations for PET response criteria in solid tumors. J Nucl Med. 2009;50:122S–50S.CrossRefPubMedCentralPubMed
25.
Seppenwoolde Y, Shirato H, Kitamura K, Shimizu S, van Herk M, Lebesque JV, et al. Prec and real-time measurement of 3D tumor motion in lung due to breathing and heartbeat, measured during radiotherapy. Int J Radiat Oncol Biol Phys. 2002;53:822–34.CrossRefPubMed
26.
Lodge MA, Chaudhry MA, Wahl RL. Noise considerations for PET quantification using maximum and peak standardized uptake value. J Nucl Med. 2012;53:1041–7.CrossRefPubMedCentralPubMed
27.
Daouk J, Fin L, Bailly P, Meyer ME. AW-OSEM parameter optimization for selected events related to the breath-hold CT position in respiratory-gated PET acquisitions. In: IEEE International Symposium on Biomedical Imaging Conference Record 2008. pp. 1323–1326.
28.
Teo B-K, Saboury B, Munbodh R, Scheuermann J, Torigian DA, Zaidi H, et al. The effect of breathing irregularities on quantitative accuracy of respiratory-gated PET/CT. Med Phys. 2012;39:7390–7.CrossRefPubMed
29.
Kyle UG, Bosaeus I, De Lorenzo AD, Deurenberg P, Elia M, Gomez JM, et al. Bioelectrical impedance analysis—part II: utilization in clinical practice. Clin Nutr. 2004;23:1430–53.CrossRefPubMed
30.
31.
Riou O, Serrano B, Azria D, Paulmier B, Villeneuve R, Fenoglietto P, et al. Integrating respiratory-gated PET-based target volume delineation in liver SBRT planning, a pilot study. Radiat Oncol. 2014;9:127.CrossRefPubMedCentralPubMed
Metadata
Title
A novel respiratory gating method for oncologic positron emission tomography based on bioimpedance approach
Authors
Tuomas Koivumäki
Jarmo Teuho
Mika Teräs
Marko Vauhkonen
Mikko A. Hakulinen
Publication date
01-05-2015
Publisher
Springer Japan
Published in
Annals of Nuclear Medicine / Issue 4/2015
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-015-0953-y

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