Published in:
01-10-2017 | Note
A new biphenyl ether derivative produced by Indonesian ascidian-derived Penicillium albobiverticillium
Authors:
Deiske A. Sumilat, Hiroyuki Yamazaki, Kotaro Endo, Henki Rotinsulu, Defny S. Wewengkang, Kazuyo Ukai, Michio Namikoshi
Published in:
Journal of Natural Medicines
|
Issue 4/2017
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Abstract
A new biphenyl ether derivative, 2-hydroxy-6-(2′-hydroxy-3′-hydroxymethyl-5-methylphenoxy)-benzoic acid (1), was isolated together with the known benzophenone derivative, monodictyphenone (2), from a culture broth of Indonesian ascidian-derived Penicillium albobiverticillium TPU1432 by solvent extraction, ODS column chromatography, and preparative HPLC (ODS). The structure of 1 was elucidated based on NMR experiments. Compound 2 exhibited moderate inhibitory activities against protein tyrosine phosphatase (PTP) 1B, T cell PTP (TCPTP), and CD45 tyrosine phosphatase (CD45), whereas compound 1 modestly inhibited CD45 activity.