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01-01-2011 | Case Report

A myxoid chondrosarcoma associated with an anti-Hu-positive paraneoplastic encephalomyelitis

Authors: Michael Hoosien, James Vredenburgh, Julio Lanfranco, Roberto Ochoa, Philip Robinson, Robert Martinez, Carlos Singer, Orlando Silva

Published in: Journal of Neuro-Oncology | Issue 1/2011

Abstract

Extraskeletal myxoid chondrosarcoma is a rare tumor with less than 100 cases reported in the literature [1]. The prevalence of anti-Hu positive myxoid chondrosarcoma-associated paraneoplastic subacute cerebellar degeneration is exceedingly rare. We present a report of a patient with confirmed myxoid chondrosarcoma-associated paraneoplastic subacute cerebellar degeneration, who exhibited marked improvement within 1 week of receiving chemotherapy, intravenous immunoglobulin (IVIG), and hydrocortisone treatment.

Chow WA (2007) Update on chondrosarcomas. Curr Opin Oncol 19:371–376CrossRefPubMed

Molinuevo J, Graus F, Serrano C et al (2004) Utility of anti-Hu antibodies in the diagnosis of paraneoplastic sensory neuropathy. Ann Neurol 44:976–980CrossRef

Verschuuren JP, Twinjstra J, De Baets M (1994) Hu antigens and anti-Hu antibodies in a patient with myxoid chondrosarcoma. Neurology 44:1551–1552PubMed

Dalmau J, Posner JB (1994) Neurologic paraneoplastic antibodies (anti-Yo, anti-Hu, anti-Ri): the case for a nomenclature based on antibody and antigen specificity. Neurology 44:2241–2246PubMed

Dalmau J, Gonzalez RG, Lerwill MF (2007) Case 4-2007: a 56-year-old woman with rapidly progressive vertigo and ataxia. N Engl J Med 356:612–620CrossRefPubMed

Dalmau J, Graus F, Rosenblum MK et al (1992) Anti-Hu-associated paraneoplastic encephalomyelitis/sensory neuropathy: a clinical study of 71 patients. Medicine 71:59–72CrossRefPubMed

Darnell RB, Posner JB (2003) Paraneoplastic syndromes involving the nervous system. N Engl J Med 349:1543–1554CrossRefPubMed

Rosenblum MK (1999) Paraneoplasia and autoimmunologic injury of the nervous system: the anti-Hu syndrome. Brain Pathol 3:199–212CrossRef

Furneaux HM, Reich L, Posner JB (1990) Autoantibody synthesis in the central nervous system of patients with paraneoplastic syndromes. Neurology 40:1085–1091PubMed

10.

Smitt PS, Kinoshita A, De Leeuw B et al (2000) Paraneoplastic cerebellar ataxia due to autoantibodies against a glutamate receptor. N Engl J Med 342:21–27CrossRef

11.

Vedeler CA, Antoine JC, Giometto B et al (2006) Paraneoplastic neurological syndrome euronetwork. Management of paraneoplastic neurological syndromes: report of an EFNS Task Force. Eur J Neurol 11:682–690CrossRef

12.

Byrne T, Mason WP, Posner JB et al (1997) Spontaneous neurological improvement in anti-Hu associated encephalomyelitis. J Neurol Neurosurg Psychiatry 62:276–278CrossRefPubMed

13.

Dalmau J, Furneaux HM, Gralla RJ et al (1990) Detection of the anti-Hu antibody in the serum of patients with small cell lung cancer—a quantitative Western blot analysis. Ann Neurol 27:544–552CrossRefPubMed

14.

Storstein A, Vedeler CA (2007) Paraneoplastic neurological syndromes and onconeural antibodies: clinical and immunological aspects. Adv Clin Chem 44:143–185CrossRefPubMed

15.

Graus F, Dalmou J, Reñé R et al (1997) Anti-Hu antibodies in patients with small-cell lung cancer: association with complete response to therapy and improved survival. J Clin Oncol 15:2866–2872PubMed

16.

Keime-Guibert F, Graus F, Fleury A et al (2000) Treatment of paraneoplastic neurological syndromes with antineuronal antibodies (anti-Hu, anti-Yo) with a combination of immunoglobulins, cyclophosphamide, and methylprednisolone. J Neurol Neurosurg Psychiatry 68:479–482CrossRefPubMed

Title: A myxoid chondrosarcoma associated with an anti-Hu-positive paraneoplastic encephalomyelitis
Authors: Michael Hoosien
James Vredenburgh
Julio Lanfranco
Roberto Ochoa
Philip Robinson
Robert Martinez
Carlos Singer
Orlando Silva
Publication date: 01-01-2011
Publisher: Springer US
Published in: Journal of Neuro-Oncology / Issue 1/2011
Print ISSN: 0167-594X
Electronic ISSN: 1573-7373
DOI: https://doi.org/10.1007/s11060-010-0216-7

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A myxoid chondrosarcoma associated with an anti-Hu-positive paraneoplastic encephalomyelitis

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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