Skip to main content
Top
Published in: BMC Musculoskeletal Disorders 1/2022

Open Access 01-12-2022 | Research

A multicenter study of 1-year mortality and walking capacity after spinal fusion surgery for cervical fracture in elderly patients

Authors: Takeshi Sasagawa, Noriaki Yokogawa, Hiroyuki Hayashi, Hiroyuki Tsuchiya, Kei Ando, Hiroaki Nakashima, Naoki Segi, Kota Watanabe, Satoshi Nori, Kazuki Takeda, Takeo Furuya, Atsushi Yunde, Shota Ikegami, Masashi Uehara, Hidenori Suzuki, Yasuaki Imajo, Toru Funayama, Fumihiko Eto, Akihiro Yamaji, Ko Hashimoto, Yoshito Onoda, Kenichiro Kakutani, Yuji Kakiuchi, Nobuyuki Suzuki, Kenji Kato, Yoshinori Terashima, Ryosuke Hirota, Tomohiro Yamada, Tomohiko Hasegawa, Kenichi Kawaguchi, Yohei Haruta, Shoji Seki, Hitoshi Tonomura, Munehiro Sakata, Hiroshi Uei, Hirokatsu Sawada, Hiroyuki Tominaga, Hiroto Tokumoto, Takashi Kaito, Yoichi Iizuka, Eiji Takasawa, Yasushi Oshima, Hidetomi Terai, Koji Tamai, Bungo Otsuki, Masashi Miyazaki, Hideaki Nakajima, Kazuo Nakanishi, Kosuke Misaki, Gen Inoue, Katsuhito Kiyasu, Koji Akeda, Norihiko Takegami, Toshitaka Yoshii, Masayuki Ishihara, Seiji Okada, Yasuchika Aoki, Katsumi Harimaya, Hideki Murakami, Ken Ishii, Seiji Ohtori, Shiro Imagama, Satoshi Kato

Published in: BMC Musculoskeletal Disorders | Issue 1/2022

Login to get access

Abstract

Background

The 1-year mortality and functional prognoses of patients who received surgery for cervical trauma in the elderly remains unclear. The aim of this study is to investigate the rates of, and factors associated with mortality and the deterioration in walking capacity occurring 1 year after spinal fusion surgery for cervical fractures in patients 65 years of age or older.

Methods

Three hundred thirteen patients aged 65 years or more with a traumatic cervical fracture who received spinal fusion surgery were enrolled. The patients were divided into a survival group and a mortality group, or a maintained walking capacity group and a deteriorated walking capacity group. We compared patients’ backgrounds, trauma, and surgical parameters between the two groups. To identify factors associated with mortality or a deteriorated walking capacity 1 year postoperatively, a multivariate logistic regression analysis was conducted.

Results

One year postoperatively, the rate of mortality was 8%. A higher Charlson comorbidity index (CCI) score, a more severe the American Spinal Cord Injury Association impairment scale (AIS), and longer surgical time were identified as independent factors associated with an increase in 1-year mortality. The rate of deterioration in walking capacity between pre-trauma and 1 year postoperatively was 33%. A more severe AIS, lower albumin (Alb) and hemoglobin (Hb) values, and a larger number of fused segments were identified as independent factors associated with the increased risk of deteriorated walking capacity 1 year postoperatively.

Conclusions

The 1-year rate of mortality after spinal fusion surgery for cervical fracture in patients 65 years of age or older was 8%, and its associated factors were a higher CCI score, a more severe AIS, and a longer surgical time. The rate of deterioration in walking capacity was 33%, and its associated factors were a more severe AIS, lower Alb, lower Hb values, and a larger number of fused segments.
Literature
1.
go back to reference Cooper Z, Mitchell SL, Lipsitz S, Harris MB, Ayanian JZ, Bernacki RE, et al. Mortality and readmission after cervical fracture from a fall in older adults: comparison with hip fracture using national medicare data. J Am Geriatr Soc. 2015;63(10):2036–42.CrossRef Cooper Z, Mitchell SL, Lipsitz S, Harris MB, Ayanian JZ, Bernacki RE, et al. Mortality and readmission after cervical fracture from a fall in older adults: comparison with hip fracture using national medicare data. J Am Geriatr Soc. 2015;63(10):2036–42.CrossRef
2.
go back to reference Asemota AO, Ahmed AK, Purvis TE, Passias PG, Goodwin CR, Sciubba DM. Analysis of cervical spine injuries in elderly patients from 2001 to 2010 using a nationwide database: increasing incidence, overall mortality, and inpatient hospital charges. World Neurosurg. 2018;120:e114–30.CrossRef Asemota AO, Ahmed AK, Purvis TE, Passias PG, Goodwin CR, Sciubba DM. Analysis of cervical spine injuries in elderly patients from 2001 to 2010 using a nationwide database: increasing incidence, overall mortality, and inpatient hospital charges. World Neurosurg. 2018;120:e114–30.CrossRef
3.
go back to reference Sokolowski MJ, Jackson AP, Haak MH, Meyer PR Jr, Sokolowski MS. Acute mortality and complications of cervical spine injuries in the elderly at a single tertiary care center. J Spinal Disord Tech. 2007;20(5):352–6.CrossRef Sokolowski MJ, Jackson AP, Haak MH, Meyer PR Jr, Sokolowski MS. Acute mortality and complications of cervical spine injuries in the elderly at a single tertiary care center. J Spinal Disord Tech. 2007;20(5):352–6.CrossRef
4.
go back to reference Menendez ME, Ring D, Harris MB, Cha TD. Predicting in-hospital mortality in elderly patients with cervical spine fractures: a comparison of the Charlson and Elixhauser comorbidity measures. Spine (Phila Pa 1976). 2015;40(11):809–15.CrossRef Menendez ME, Ring D, Harris MB, Cha TD. Predicting in-hospital mortality in elderly patients with cervical spine fractures: a comparison of the Charlson and Elixhauser comorbidity measures. Spine (Phila Pa 1976). 2015;40(11):809–15.CrossRef
5.
go back to reference Malik SA, Murphy M, Connolly P, O’Byrne J. Evaluation of morbidity, mortality and outcome following cervical spine injuries in elderly patients. Eur Spine J. 2008;17(4):585–91.CrossRef Malik SA, Murphy M, Connolly P, O’Byrne J. Evaluation of morbidity, mortality and outcome following cervical spine injuries in elderly patients. Eur Spine J. 2008;17(4):585–91.CrossRef
6.
go back to reference Harris MB, Reichmann WM, Bono CM, Bouchard K, Corbett KL, Warholic N, et al. Mortality in elderly patients after cervical spine fractures. J Bone Joint Surg Am. 2010;92(3):567–74.CrossRef Harris MB, Reichmann WM, Bono CM, Bouchard K, Corbett KL, Warholic N, et al. Mortality in elderly patients after cervical spine fractures. J Bone Joint Surg Am. 2010;92(3):567–74.CrossRef
7.
go back to reference Sander AL, El Saman A, Delfosse P, Wutzler S, Meier S, Marzi I, et al. Cervical spine fractures in the elderly: morbidity and mortality after operative treatment. Eur J Trauma Emerg Surg. 2013;39(5):469–76.CrossRef Sander AL, El Saman A, Delfosse P, Wutzler S, Meier S, Marzi I, et al. Cervical spine fractures in the elderly: morbidity and mortality after operative treatment. Eur J Trauma Emerg Surg. 2013;39(5):469–76.CrossRef
8.
go back to reference Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373–83.CrossRef Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373–83.CrossRef
9.
go back to reference Kirshblum SC, Burns SP, Biering-Sorensen F, Donovan W, Graves DE, Jha A, et al. International standards for neurological classification of spinal cord injury (revised 2011). J Spinal Cord Med. 2011;34(6):535–46.CrossRef Kirshblum SC, Burns SP, Biering-Sorensen F, Donovan W, Graves DE, Jha A, et al. International standards for neurological classification of spinal cord injury (revised 2011). J Spinal Cord Med. 2011;34(6):535–46.CrossRef
10.
go back to reference Downey C, Kelly M, Quinlan JF. Changing trends in the mortality rate at 1-year post hip fracture - a systematic review. World J Orthop. 2019;10(3):166–75.CrossRef Downey C, Kelly M, Quinlan JF. Changing trends in the mortality rate at 1-year post hip fracture - a systematic review. World J Orthop. 2019;10(3):166–75.CrossRef
11.
go back to reference Shigemoto K, Sawaguchi T, Horii T, Goshima K, Iwai S, Higashikawa T, et al. Multidisciplinary care model for geriatric patients with hip fracture in Japan: 5-year experience. Arch Orthop Trauma. 2022;142(9):2205–14. Shigemoto K, Sawaguchi T, Horii T, Goshima K, Iwai S, Higashikawa T, et al. Multidisciplinary care model for geriatric patients with hip fracture in Japan: 5-year experience. Arch Orthop Trauma. 2022;142(9):2205–14.
12.
go back to reference Golob JF Jr, Claridge JA, Yowler CJ, Como JJ, Peerless JR. Isolated cervical spine fractures in the elderly: a deadly injury. J Trauma. 2008;64(2):311–5.PubMed Golob JF Jr, Claridge JA, Yowler CJ, Como JJ, Peerless JR. Isolated cervical spine fractures in the elderly: a deadly injury. J Trauma. 2008;64(2):311–5.PubMed
13.
go back to reference Daneshvar P, Roffey DM, Brikeet YA, Tsai EC, Bailey CS, Wai EK. Spinal cord injuries related to cervical spine fractures in elderly patients: factors affecting mortality. Spine J. 2013;13(8):862–6.CrossRef Daneshvar P, Roffey DM, Brikeet YA, Tsai EC, Bailey CS, Wai EK. Spinal cord injuries related to cervical spine fractures in elderly patients: factors affecting mortality. Spine J. 2013;13(8):862–6.CrossRef
14.
go back to reference Inglis T, Banaszek D, Rivers CS, Kurban D, Evaniew N, Fallah N, et al. In-Hospital Mortality for the Elderly with Acute Traumatic Spinal Cord Injury. J Neurotrauma. 2020;37(21):2332–42.CrossRef Inglis T, Banaszek D, Rivers CS, Kurban D, Evaniew N, Fallah N, et al. In-Hospital Mortality for the Elderly with Acute Traumatic Spinal Cord Injury. J Neurotrauma. 2020;37(21):2332–42.CrossRef
15.
go back to reference Kerwin AJ, Frykberg ER, Schinco MA, Griffen MM, Arce CA, Nguyen TQ, et al. The effect of early surgical treatment of traumatic spine injuries on patient mortality. J Trauma. 2007;63(6):1308–13.PubMed Kerwin AJ, Frykberg ER, Schinco MA, Griffen MM, Arce CA, Nguyen TQ, et al. The effect of early surgical treatment of traumatic spine injuries on patient mortality. J Trauma. 2007;63(6):1308–13.PubMed
16.
go back to reference Nagata K, Shinozaki T, Yamada K, Nakajima K, Nakamoto H, Yamakawa K, et al. A sliding scale to predict postoperative complications undergoing posterior spine surgery. J Orthop Sci. 2020;25(4):545–50.CrossRef Nagata K, Shinozaki T, Yamada K, Nakajima K, Nakamoto H, Yamakawa K, et al. A sliding scale to predict postoperative complications undergoing posterior spine surgery. J Orthop Sci. 2020;25(4):545–50.CrossRef
17.
go back to reference Bokhari AR, Sivakumar B, Sefton A, Lin JL, Smith MM, Gray R, et al. Morbidity and mortality in cervical spine injuries in the elderly. ANZ J Surg. 2019;89(4):412–7.CrossRef Bokhari AR, Sivakumar B, Sefton A, Lin JL, Smith MM, Gray R, et al. Morbidity and mortality in cervical spine injuries in the elderly. ANZ J Surg. 2019;89(4):412–7.CrossRef
18.
go back to reference Cooper C. The crippling consequences of fractures and their impact on quality of life. Am J Med. 1997;103(2A):12S-17S (discussion 17S-19S).CrossRef Cooper C. The crippling consequences of fractures and their impact on quality of life. Am J Med. 1997;103(2A):12S-17S (discussion 17S-19S).CrossRef
19.
go back to reference Kitamura S, Hasegawa Y, Suzuki S, Sasaki R, Iwata H, Wingstrand H, et al. Functional outcome after hip fracture in Japan. Clin Orthop Relat Res. 1998;348:29–36.CrossRef Kitamura S, Hasegawa Y, Suzuki S, Sasaki R, Iwata H, Wingstrand H, et al. Functional outcome after hip fracture in Japan. Clin Orthop Relat Res. 1998;348:29–36.CrossRef
20.
go back to reference Moerman S, Mathijssen NM, Tuinebreijer WE, Nelissen RG, Vochteloo AJ. Less than one-third of hip fracture patients return to their prefracture level of instrumental activities of daily living in a prospective cohort study of 480 patients. Geriatr Gerontol Int. 2018;18(8):1244–8.CrossRef Moerman S, Mathijssen NM, Tuinebreijer WE, Nelissen RG, Vochteloo AJ. Less than one-third of hip fracture patients return to their prefracture level of instrumental activities of daily living in a prospective cohort study of 480 patients. Geriatr Gerontol Int. 2018;18(8):1244–8.CrossRef
21.
go back to reference Jakob W, Wirz M, van Hedel HJ, Dietz V, EM-SCI Study Group. Difficulty of elderly SCI subjects to translate motor recovery–"body function"–into daily living activities. J Neurotrauma. 2009;26(11):2037–44.CrossRef Jakob W, Wirz M, van Hedel HJ, Dietz V, EM-SCI Study Group. Difficulty of elderly SCI subjects to translate motor recovery–"body function"–into daily living activities. J Neurotrauma. 2009;26(11):2037–44.CrossRef
22.
go back to reference Sim SD, Sim YE, Tay K, Howe TS, Png MA, Chang CCP, et al. Preoperative hypoalbuminemia: Poor functional outcomes and quality of life after hip fracture surgery. Bone. 2021;143: 115567.CrossRef Sim SD, Sim YE, Tay K, Howe TS, Png MA, Chang CCP, et al. Preoperative hypoalbuminemia: Poor functional outcomes and quality of life after hip fracture surgery. Bone. 2021;143: 115567.CrossRef
23.
go back to reference Lieberman D, Friger M, Lieberman D. Inpatient rehabilitation outcome after hip fracture surgery in elderly patients: a prospective cohort study of 946 patients. Arch Phys Med Rehabil. 2006;87(2):167–71.CrossRef Lieberman D, Friger M, Lieberman D. Inpatient rehabilitation outcome after hip fracture surgery in elderly patients: a prospective cohort study of 946 patients. Arch Phys Med Rehabil. 2006;87(2):167–71.CrossRef
24.
go back to reference Jin GX, Li L, Cui SQ, Duan JZ, Wang H. Persistent hypoalbuminemia is a predictor of outcome in cervical spinal cord injury. Spine J. 2014;14(9):1902–8.CrossRef Jin GX, Li L, Cui SQ, Duan JZ, Wang H. Persistent hypoalbuminemia is a predictor of outcome in cervical spinal cord injury. Spine J. 2014;14(9):1902–8.CrossRef
25.
go back to reference Sim YE, Sim SD, Seng C, Howe TS, Koh SB, Abdullah HR. Preoperative anemia, functional outcomes, and quality of life after hip fracture surgery. J Am Geriatr Soc. 2018;66(8):1524–31.CrossRef Sim YE, Sim SD, Seng C, Howe TS, Koh SB, Abdullah HR. Preoperative anemia, functional outcomes, and quality of life after hip fracture surgery. J Am Geriatr Soc. 2018;66(8):1524–31.CrossRef
26.
go back to reference Hagino T, Ochiai S, Sato E, Maekawa S, Wako M, Haro H. The relationship between anemia at admission and outcome in patients older than 60 years with hip fracture. J Orthop Traumatol. 2009;10(3):119–22.CrossRef Hagino T, Ochiai S, Sato E, Maekawa S, Wako M, Haro H. The relationship between anemia at admission and outcome in patients older than 60 years with hip fracture. J Orthop Traumatol. 2009;10(3):119–22.CrossRef
27.
go back to reference Ng TP, Feng L, Nyunt MS, Larbi A, Yap KB. Frailty in older persons: multisystem risk factors and the Frailty Risk Index (FRI). J Am Med Dir Assoc. 2014;15(9):635–42.CrossRef Ng TP, Feng L, Nyunt MS, Larbi A, Yap KB. Frailty in older persons: multisystem risk factors and the Frailty Risk Index (FRI). J Am Med Dir Assoc. 2014;15(9):635–42.CrossRef
28.
go back to reference Bell KM, Bechara BP, Hartman RA, Shively C, Frazier EC, Lee JY, et al. Influence of number of operated levels and postoperative time on active range of motion following anterior cervical decompression and fusion procedures. Spine (Phila Pa 1976). 2011;36(4):263–8.CrossRef Bell KM, Bechara BP, Hartman RA, Shively C, Frazier EC, Lee JY, et al. Influence of number of operated levels and postoperative time on active range of motion following anterior cervical decompression and fusion procedures. Spine (Phila Pa 1976). 2011;36(4):263–8.CrossRef
29.
go back to reference Ohnishi K, Miyamoto K, Kato T, Shimizu K. Effects of wearing halo vest on gait: three-dimensional analysis in healthy subjects. Spine (Phila Pa 1976). 2011;30(7):750–5.CrossRef Ohnishi K, Miyamoto K, Kato T, Shimizu K. Effects of wearing halo vest on gait: three-dimensional analysis in healthy subjects. Spine (Phila Pa 1976). 2011;30(7):750–5.CrossRef
Metadata
Title
A multicenter study of 1-year mortality and walking capacity after spinal fusion surgery for cervical fracture in elderly patients
Authors
Takeshi Sasagawa
Noriaki Yokogawa
Hiroyuki Hayashi
Hiroyuki Tsuchiya
Kei Ando
Hiroaki Nakashima
Naoki Segi
Kota Watanabe
Satoshi Nori
Kazuki Takeda
Takeo Furuya
Atsushi Yunde
Shota Ikegami
Masashi Uehara
Hidenori Suzuki
Yasuaki Imajo
Toru Funayama
Fumihiko Eto
Akihiro Yamaji
Ko Hashimoto
Yoshito Onoda
Kenichiro Kakutani
Yuji Kakiuchi
Nobuyuki Suzuki
Kenji Kato
Yoshinori Terashima
Ryosuke Hirota
Tomohiro Yamada
Tomohiko Hasegawa
Kenichi Kawaguchi
Yohei Haruta
Shoji Seki
Hitoshi Tonomura
Munehiro Sakata
Hiroshi Uei
Hirokatsu Sawada
Hiroyuki Tominaga
Hiroto Tokumoto
Takashi Kaito
Yoichi Iizuka
Eiji Takasawa
Yasushi Oshima
Hidetomi Terai
Koji Tamai
Bungo Otsuki
Masashi Miyazaki
Hideaki Nakajima
Kazuo Nakanishi
Kosuke Misaki
Gen Inoue
Katsuhito Kiyasu
Koji Akeda
Norihiko Takegami
Toshitaka Yoshii
Masayuki Ishihara
Seiji Okada
Yasuchika Aoki
Katsumi Harimaya
Hideki Murakami
Ken Ishii
Seiji Ohtori
Shiro Imagama
Satoshi Kato
Publication date
01-12-2022
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2022
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/s12891-022-05752-5

Other articles of this Issue 1/2022

BMC Musculoskeletal Disorders 1/2022 Go to the issue