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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 2/2019

Open Access 01-02-2019 | Head and Neck Oncology

A Multicenter Retrospective Study of Elective Neck Dissection for T1-2N0M0 Tongue Squamous Cell Carcinoma: Analysis Using Propensity Score-Matching

Authors: Mitsunobu Otsuru, DDS, PhD, Yoshihide Ota, DDS, PhD, Souichi Yanamoto, DDS, PhD, Masaya Okura, DDS, PhD, Masahiro Umeda, DDS, PhD, Tadaaki Kirita, DDS, PhD, Hiroshi Kurita, DDS, PhD, Michihiro Ueda, DDS, PhD, Takahide Komori, DDS, PhD, Nobuhiro Yamakawa, DDS, PhD, Takahiro Kamata, DDS, PhD, Takumi Hasegawa, DDS, PhD, Takahiko Shibahara, DDS, PhD, Youichi Ohiro, DDS, PhD, Yoshihiro Yamashita, DDS, PhD, Kazuma Noguchi, DDS, PhD, Tadahide Noguchi, DDS, PhD, Kazunari Karakida, DDS, PhD, Hiroyuki Naito, DDS, PhD, Tomonao Aikawa, DDS, PhD, Tetsuro Yamashita, DDS, PhD, Daijiro Kabata, MPH, Ayumi Shintani, MPH, PhD

Published in: Annals of Surgical Oncology | Issue 2/2019

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Abstract

Background

This multicenter retrospective study aimed to determine whether elective neck dissection (END) can be performed for T1-2N0M0 tongue cancer.

Methods

Patients with T1-2N0M0 tongue squamous cell carcinoma who received treatment between January 2000 and December 2012 were enrolled at 14 multicenter study sites. The 5-year overall survival (OS) and 5-year disease-specific survival (DSS) were compared between the propensity score-matched END and observation (OBS) groups.

Results

The results showed that the OS rates among the 1234 enrolled patients were 85.5% in the END group and 90.2% in the OBS group (P = 0.182). The DSS rates were 87.0% in the END group and 94.3% in the OBS group (P = 0.003). Among the matched patients, the OS rates were 87.1% in the END group and 76.2% in the OBS group (P = 0.0051), and the respective DSS rates were 89.2% and 82.2% (P = 0.0335).

Conclusion

This study showed that END is beneficial for T1-2N0M0 tongue cancer. However, END should be performed for patients with a tumor depth of 4–5 mm or more, which is the depth associated with a high rate of lymph node metastasis. The use of END should be carefully considered for both elderly and young patients.
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Metadata
Title
A Multicenter Retrospective Study of Elective Neck Dissection for T1-2N0M0 Tongue Squamous Cell Carcinoma: Analysis Using Propensity Score-Matching
Authors
Mitsunobu Otsuru, DDS, PhD
Yoshihide Ota, DDS, PhD
Souichi Yanamoto, DDS, PhD
Masaya Okura, DDS, PhD
Masahiro Umeda, DDS, PhD
Tadaaki Kirita, DDS, PhD
Hiroshi Kurita, DDS, PhD
Michihiro Ueda, DDS, PhD
Takahide Komori, DDS, PhD
Nobuhiro Yamakawa, DDS, PhD
Takahiro Kamata, DDS, PhD
Takumi Hasegawa, DDS, PhD
Takahiko Shibahara, DDS, PhD
Youichi Ohiro, DDS, PhD
Yoshihiro Yamashita, DDS, PhD
Kazuma Noguchi, DDS, PhD
Tadahide Noguchi, DDS, PhD
Kazunari Karakida, DDS, PhD
Hiroyuki Naito, DDS, PhD
Tomonao Aikawa, DDS, PhD
Tetsuro Yamashita, DDS, PhD
Daijiro Kabata, MPH
Ayumi Shintani, MPH, PhD
Publication date
01-02-2019
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 2/2019
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-018-07089-7

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