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Critical Care
Published in: Critical Care 3/2012

Open Access 01-06-2012 | Letter

A method for detection and quantification of hydroxyethyl starch in plasma

Authors: Gordon P Otto, Bianka Wissuwa, Anne Mehnert, Sascha Marx, Michael Raessler, Wolfgang Lösche, Ralf A Claus, Maik Sossdorf

Published in: Critical Care | Issue 3/2012

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Excerpt

The use of hydroxyethylstarch (HES) is a controversial issue due to increasing evidence that HES accumulates in plasma and various tissues and therefore leads to unfavourable outcome in critically ill patients [1, 2]. No simple methods are available for monitoring HES plasma levels; present technologies to measure HES are based on gas chromatography-mass spectrometry, which are time-consuming and need advanced equipment [3]. Here, we applied Lugol's iodine solution (LUGOL; Sigma-Aldrich, Steinheim, Germany) to determinate HES concentrations in plasma and compare the results with those obtained by high-performance liquid chromatography (HPLC). …
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Literature
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Brunkhorst FM, Engel C, Bloos F, Meier-Hellmann A, Ragaller M, Weiler N, Moerer O, Gruendling M, Oppert M, Grond S, Olthoff D, Jaschinski U, John S, Rossaint R, Welte T, Schaefer M, Kern P, Kuhnt E, Kiehntopf M, Hartog C, Natanson C, Loeffler M, Reinhart K, German Competence Network Sepsis (SepNet): Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med 2008, 358: 125-139.CrossRefPubMed
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Hartog CS, Kohl M, Reinhart K: A systematic review of third-generation hydroxyethyl starch (HES 130/0.4) in resuscitation: safety not adequately addressed. Anesth Analg 2011, 112: 635-645.CrossRefPubMed
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Deventer K, Van Eenoo P, Delbeke FT: Detection of hydroxyethylstarch (HES) in human urine by liquid chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2006, 834: 217-220.CrossRefPubMed
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Raessler M, Wissuwa B, Breul A, Unger W, Grimm T: Determination of water-extractable nonstructural carbohydrates, including inulin, in grass samples with high-performance anion exchange chromatography and pulsed amperometric detection. J Agric Food Chem 2008, 56: 7649-7654.CrossRefPubMed
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Lutkic A, Cepo M, Dodikovic V, Zjacic-Rotkvic V, Goldoni V, Mazuranic V, Cabrijan T, Cizmic A, Jurilj N: Concentration of glycogen in blood of diabetics. Clin Investig 1992, 70: 707.CrossRefPubMed
Metadata
Title
A method for detection and quantification of hydroxyethyl starch in plasma
Authors
Gordon P Otto
Bianka Wissuwa
Anne Mehnert
Sascha Marx
Michael Raessler
Wolfgang Lösche
Ralf A Claus
Maik Sossdorf
Publication date
01-06-2012
Publisher
BioMed Central
Published in
Critical Care / Issue 3/2012
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc11302

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