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01-12-2003 | Research Article

A medullary source of norepinephrine in cat cochlear nuclear complex

Author: Ann M. Thompson

Published in: Experimental Brain Research | Issue 4/2003

Abstract

Norepinephrine is believed to modulate important functions of the cochlear nuclear complex (CNC) such as the detection of signals in noise and the processing of timing cues. To better understand the impact of the noradrenergic system in the CNC, we used neurotransmitter immunohistochemistry combined with retrograde tract-tracing to identify the noradrenrgic cell groups that project to the CNC. Here we present data showing that the CNC receives noradrenergic inputs from the A1 cell group located in the ventrolateral medulla. The projection from A1 to the CNC may be part of a system-wide modulation by the noradrenergic system based on stress and arousal level, or it may be part of a separate circuit that modulates its targets during survival behaviors.

Berman AL (1968) The brain stem of the cat. University of Wisconsin Press, Madison

Blessing WW, Frost P, Furness JB (1980) Catecholamine cell groups of the cat medulla oblongata. Brain Res 192:69–75CrossRefPubMed

Carlton SM, Honda CN, Denoroy L (1989) Distribution of phenylethanolamine N-methyltransferase cell bodies, axons, and terminals in monkey brainstem: an immunohistochemical mapping study. J Comp Neurol 287:273–285PubMed

Chikamori Y, Sasa M, Fujimoto S, Takaori S, Matsuoka I (1980) Locus coeruleus-induced inhibition of dorsal cochlear nucleus neurons in comparison with lateral vestibular nucleus neurons. Brain Res 184:53–63CrossRef

Ciriello JM Caverson M, Polosa C (1986) Function of the ventrolateral medulla in the control of the circulation. Brain Res Rev 11:359–391CrossRef

Comis SD, Whitfield IC (1968) Influence of centrifugal pathways on unit activity in the cochlear nucleus. J Neurophysiol 31:62–68PubMed

Dahlström A, Fuxe K (1964) Evidence for the existence of monoamine-containing neruons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons. Acta Physiol Scand 62:1–55

Dayas CV, Buller KM, Crane JW, Xu Y, Day TA (2001) Stressor categorization: acute physical and psychological stressors elicit distinctive recruitment patterns in the amygdala and in medullary noradrenergic cell groups. Eur J Neurosci 14:1143–1152CrossRefPubMed

Ebert U (1996) Noradrenaline enhances the activity of cochlear nucleus neurons in the rat. Eur J Neurosci 8:1306–1314PubMed

Floody OR, Lisk RD (1987) Effects of sex and reproductive state on acoustic responsiveness in hamsters. Brain Res Bull 18:235–242CrossRefPubMed

Haenggeli CA, Doucet JR, Ryugo DK (2002) Projections of the spinal trigeminal nucleus to the cochlear nucleus. In: Proceedings of the Scientific Program, Central Auditory Processing: Integration of Auditory and Non-Auditory Information, Monté Verita, Switzerland. Abstract P36

Herbert H, Saper CB (1992) Organization of medullary adrenergic and noradrenergic projections to the periaqueductal gray matter in the rat. J Comp Neurol 315:34–52PubMed

Hökfelt T, Johansson O, Goldstein M (1984) Central catecholamine neurons as revealed by immunohistochemistry with special reference to adrenaline neurons. In: Bjorklund A, Hökfelt T (eds) Handbook of Chemical Neuroanatomy, Vol 2: Classical Transmitters in the CNS. Elsevier, Amsterdam, pp 157–276

Klepper A, Herbert H (1991) Distribution and origin of noradrenergic and serotonergic fibers in the cochlear nucleus and inferior colliculus of the rat. Brain Res 557:190–201CrossRefPubMed

Klop EM, Mouton LJ, Holstege G. (2002) Nucleus retroambiguus projections to the periaqueductal gray in the cat. J Comp Neurol 445:47–58CrossRefPubMed

Kössl M, Vater M (1989) Noradrenaline enhances temporal auditory contrast and neuronal timing precision in the cochlear nucleus of the mustached bat. J Neurosci 9:4169–4178PubMed

Kössl M, Vater M, Schweizer H (1988) Distribution of catecholamine fibers in the cochlear nucleus of horseshoe bats and mustache bats. J Comp Neurol 269:523–534PubMed

Kromer LF, Moore RY (1976) Cochlear nucleus innervation by central norepinephrine neurons in the rat. Brain Res 118:531–537CrossRefPubMed

Llewllyn-Smith IJ, Pilowsky P, Minson JB (1992) Retrograde tracers for light and electron microscopy. In: Bolam JP (ed) Experimental Neuroanatomy: a Practical Approach. Oxford University Press, New York, pp 31–59

Matta SG, Foster CA, Sharp BM (1993) Nicotine stimulates the expression of cFos protein in the parvocellular paraventricular nucleus and brainstem catecholaminergic regions. Endocrinology 132:2149–2156PubMed

McKellar S, Loewy AD (1982) Efferent projections of the A1 catecholamine cell group in the rat: an autoradiographic study. Brain Res 241:11–29CrossRefPubMed

Milner TA, Pickel VM, Giuliano R, Reis DJ (1989) Ultrastructural localization of choline acetyltransferase in the rat rostral ventrolateral medulla: evidence for major synaptic relations with non-catecholaminergic neurons. Brain Res 500:67–89CrossRefPubMed

Onaka T, Yamashita T, Liu X, Honda K, Saito T, Yagi K (2001) Medullary A1 noradrenergic neurones may mediate oxytocin release after noxious stimuli. Neuroreport 12:2499–2502PubMed

Pacak K, Palkovits M, Kvetnansky R, Kopin IJ, Goldstein DS (1993) Stress-induced norepinephrine release in the paraventricular nucleus of rats with brain-stem hemisections: a microdialysis study. Neuroendocrinology 58:196–201PubMed

Pasquier DA, Gold MA, Jacobowitz DM (1980) Noradrenergic perikarya (A5–A7, subcoeruleus) projections to the rat cerebellum. Brain Res 196:270–275CrossRefPubMed

Pau KY, Yu JH, Lee CJ, Spies HG (1998) Topographic localization of neuropeptide Y mRNA in the monkey brainstem. Regul Pept 75–76:145–153

Pickles JO (1976) The noradrenaline-containing innervation of the cochlear nucleus and the detection of signals in noise. Brain Res 105:591–596CrossRefPubMed

Pickles JO, Comis SD (1973) Role of centrifugal pathways to cochlear nucleus in detection of signals in noise. J.Neurophysiol 36:1131–1137

Poitras D, Parent A (1978) Atlas of the distribution of monoamine-containing nerve cell bodies in the brain stem of the cat. J Comp Neurol 179:699–718PubMed

Reiner PB, Vincent SR (1986) The distribution of tyrosine hydroxylase, dopamine-β-hydroxylase, and phenylethanolamine-N-methyltransferase immunoreactive neurons in the feline medulla oblongata. J Comp Neurol 248:518–531PubMed

Rinaman L (2001) Postnatal development of catecholamine inputs to the paraventricular nucleus of the hypothalamus in rats. J Comp Neurol 438:411–422CrossRefPubMed

Roder S, Ciriello J (1993) Innervation of the amygdaloid complex by catecholaminergic cell groups of the ventrolateral medulla. J Comp Neurol 332:105–122PubMed

Ruggiero DA, Meeley MP, Anwar M, Reis DJ (1985) Newly identified GABAergic neurons in regions of the ventrolateral medulla which regulate blood pressure. Brain Res 339:171–177CrossRefPubMed

Rusnak M, Kvetnansky R, Jelokova J, Palkovits M (2001) Effect of novel stressors on gene expression of tyrosine hydroxylase and monoamine transporters in brainstem noradrenergic neurons of long-term repeatedly immobilized rats. Brain Res 899:20–35CrossRefPubMed

Schuerger RJ, Balaban CD (1993) Immunohistochemical demonstration of regionally selective projections from locus coeruleus to the vestibular nuclei in rats. Exp Brain Res 92:351–359PubMed

Thompson AM (1998) Heterogeneous projections of the cat posteroventral cochlear nucleus. J Comp Neurol 390:439–453CrossRefPubMed

Thompson, AM (2003) Pontine sources of norepinephrine in cat cochlear nucleus. J Comp Neurol 457:374–383CrossRefPubMed

Thompson AM, Moore KR, Thompson GC (1995) Distribution and origin of serotoninergic afferents to guinea pig cochlear nucleus. J Comp Neurol 351:104–116PubMed

Woulfe JM, Flumerfelt BA, Hrycyshyn AW (1990) Efferent connections of the A1 noradrenergic cell group: A DBH immunohistochemical and PHA-L anterograde tracing study. Exp Neurol 109:308–322PubMed

Yang SP, Voogt JL (2001) Mating-activated brainstem catecholaminergic neurons in the female rat. Brain Res 894:159–166CrossRefPubMed

Title: A medullary source of norepinephrine in cat cochlear nuclear complex
Author: Ann M. Thompson
Publication date: 01-12-2003
Publisher: Springer-Verlag
Published in: Experimental Brain Research / Issue 4/2003
Print ISSN: 0014-4819
Electronic ISSN: 1432-1106
DOI: https://doi.org/10.1007/s00221-003-1681-4

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A medullary source of norepinephrine in cat cochlear nuclear complex

Abstract

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