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Osteoporosis International

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01-01-2010 | Original Article

A longitudinal Raman microspectroscopic study of osteoporosis induced by spinal cord injury

Authors: J. Shen, L. Fan, J. Yang, A. G. Shen, J. M. Hu

Published in: Osteoporosis International | Issue 1/2010

Abstract

Introduction

A longitudinal study was established to investigate bone compositional information in spinal cord injury (SCI) rat model.

Methods

Raman spectroscopy was applied to detect the distal femur and humeri of SCI, sham-operated (SO), and age-matched control (CON) male Sprague-Dawley (SD) rats at first, second, third, and fifth weeks after surgery. One-way ANOVA and Tukey’s HSD post hoc multiple comparison tests were used to analyze the longitudinal data of mineral to matrix ratio and carbonate substitution.

Results

Relative mineral decrease was found in SCI group by more than 20% in femur and approximately 12% in humeri compared with CON group. No significant changes in carbonate substitution were observed.

Conclusions

Severe bone loss in the early stage of SCI was confirmed by a continuous decrease of the mineral to collagen matrix ratio. The decrease in the humeri suggested hormone level variations might participate in the etiology of SCI-induced osteoporosis.

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Title: A longitudinal Raman microspectroscopic study of osteoporosis induced by spinal cord injury
Authors: J. Shen
L. Fan
J. Yang
A. G. Shen
J. M. Hu
Publication date: 01-01-2010
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 1/2010
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-009-0949-3

At a glance: The STEP trials

Springer Medicine

A longitudinal Raman microspectroscopic study of osteoporosis induced by spinal cord injury

Abstract

Introduction

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

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